ITGAV/ITGB5 Protein (His tag)

N° du produit ABIN7316902

Détail du produit

Antigène: ITGAV/ITGB5 (Integrin alpha V / beta 5 (ITGAV/ITGB5))

Type de proteíne: Recombinant

Origine: Rat

Source: HEK-293 Cells

Purification/Conjugué: Cette ITGAV/ITGB5 protéine est marqué à la His tag.

Fonction: Rat Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His Tag&Tag Free

Séquence: Phe 31 - Pro 988 (ITGAM) & Leu 25 - Asn 719 (ITGB5)

Attributs du produit: Rat ITGAV&ITGB5 Heterodimer, His Tag&Tag Free is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Pro 988 (ITGAM) & Leu 25 - Asn 719 (ITGB5) (Accession # NP_001385621.1 (ITGAM) & NP_671480.2 (ITGB5).

Pureté: 90,00 %

niveau d'endotoxine: 1.0 EU per μg

Information d'application

Commentaires:

Rat ITGAV&ITGB5 Heterodimer, His Tag&Tag Free, has a calculated MW of 112.3 kDa (ITGAV) & 81.6 kDa (ITGB3). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB3 contains no tag but a basic tail at the C-terminus.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris, 150 mM NaCl, pH 7.5

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: ITGAV/ITGB5 (Integrin alpha V / beta 5 (ITGAV/ITGB5))

Autre désignation: Integrin alpha V beta 5 (ITGAV/ITGB5 Produits)

Sujet: Synonyms:Integrin alpha V beta 5,ITGAV&ITGB5,Description:Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.

Poids moléculaire: 112.3 kDa | 81.7 kDa