ITGAV/ITGB8 Protein (AA 31-992) (His tag)
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- Antigène Tous les produits ITGAV/ITGB8
- ITGAV/ITGB8 (Integrin alpha V beta 8 (ITGAV/ITGB8))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 31-992
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette ITGAV/ITGB8 protéine est marqué à la His tag.
- Application
- Functional Studies (Func)
- Séquence
- AA 31-992
- Attributs du produit
- Human ITGAV & ITGB8 Heterodimer Protein, produced by co-expression of ITGAV and ITGB8, has a calculated MW of 113 kDa (ITGAV) and 75.5 kDa (ITGB8). Subunit ITGAV is fused with polyhistidine tag at the C-terminus and followed by a acidic tail and subunit ITGB8 contains no tag but a basic tail at the C-terminus. The reducing (R) protein migrates as 145 kDa (ITGAV) and 100-116 kDa (ITGB8) respectively due to glycosylation.
- Pureté
- >95 % as determined by SDS-PAGE.
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
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Integrin alpha V beta 8 (ITGAV/ITGB8) (AA 31-993) protein (His tag)
ITGAV/ITGB8 Origine: Macaque rhésus Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Integrin alpha V beta 8 (ITGAV/ITGB8) (AA 31-988) (Active) protein (His tag)ITGAV/ITGB8 Origine: Souris Hôte: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
Integrin alpha V beta 8 (ITGAV/ITGB8) (AA 31-992) protein (His tag,AVI tag,Biotin)ITGAV/ITGB8 Origine: Humain Hôte: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 100 mM NaCl, pH 8.0
- Conseil sur la manipulation
- Please avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
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- Antigène
- ITGAV/ITGB8 (Integrin alpha V beta 8 (ITGAV/ITGB8))
- Autre désignation
- Integrin alpha V beta 8 (ITGAV/ITGB8 Produits)
- Sujet
- Integrin alpha V beta 8 (ITGAV & ITGB8 or ITGAVB8) is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells. Unlike other alpha V integrins, ITGAVB8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP, which releases active TGF-beta. This mechanism differs from that of alpha V beta 6, the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms. Downstream effects of TGF-beta activation include control of cell growth and associated vascularization.
- Poids moléculaire
- 112.9 kDa (ITGAV) & 76.5 kDa (ITGB8)
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