ITGAV/ITGB8 Protein (Biotin,His-Avi Tag)

N° du produit ABIN7316905

Détail du produit

Antigène: ITGAV/ITGB8 (Integrin alpha V beta 8 (ITGAV/ITGB8))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette ITGAV/ITGB8 protéine est marqué à la Biotin,His-Avi Tag.

Fonction: Biotinylated Mouse Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein, His,Avitag™&Tag Free

Séquence: Phe 31 - Val 988 & Gly 22 - Leu 681

Attributs du produit: Biotinylated Mouse ITGAV&ITGB8 Heterodimer Protein is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 988 & Gly 22 - Leu 681 (Accession # P43406-1 & Q0VBD0-1).

Pureté: 95,00 %

niveau d'endotoxine: 1.0 EU per μg

Information d'application

Commentaires:

Biotinylated Mouse ITGAV&ITGB8 Heterodimer Protein has a calculated MW of 114.2 kDa (ITGAV) & 77.5 kDa (ITGB8). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and an Avi tag (Avitag™) and subunit ITGB8 contains no tag but a basic tail at the C-terminus.The protein migrates as 80-90 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris, 150 mM NaCl, pH 7.5

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: ITGAV/ITGB8 (Integrin alpha V beta 8 (ITGAV/ITGB8))

Autre désignation: Integrin alpha V beta 8 (ITGAV/ITGB8 Produits)

Sujet: Synonyms:Integrin alpha V beta 8,ITGAV&ITGB8,Description:Integrin alpha V beta 8 (ITGAV & ITGB8 or ITGAVB8) is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells. Unlike other alpha V integrins, ITGAVB8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP, which releases active TGF-beta. This mechanism differs from that of alpha V beta 6, the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms. Downstream effects of TGF-beta activation include control of cell growth and associated vascularization.

Poids moléculaire: 114.2 kDa | 77.5 kDa