ITGAV/ITGB8 Protein (AA 31-988) (His tag)

N° du produit ABIN6809904

Détail du produit

Antigène: ITGAV/ITGB8 (Integrin alpha V beta 8 (ITGAV/ITGB8))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 31-988

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette ITGAV/ITGB8 protéine est marqué à la His tag.

Séquence: AA 31-988

Pureté: >95 % as determined by reduced SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris, 150 mM NaCl, pH 7.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Détail du antigène

Antigène: ITGAV/ITGB8 (Integrin alpha V beta 8 (ITGAV/ITGB8))

Autre désignation: Integrin alpha V beta 8 (ITGAV/ITGB8 Produits)

Sujet: Integrin alpha V beta 8 (ITGAV & ITGB8 or ITGAVB8) is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells. Unlike other alpha V integrins, ITGAVB8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP, which releases active TGF-beta. This mechanism differs from that of alpha V beta 6, the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms. Downstream effects of TGF-beta activation include control of cell growth and associated vascularization.

Poids moléculaire: 112.5 kDa (ITGAV) & 77.5 kDa (ITGB8)