ITGAV/ITGB8 Protein (AA 31-993) (His tag)

N° du produit ABIN7275078

Détail du produit

Antigène: ITGAV/ITGB8 (Integrin alpha V beta 8 (ITGAV/ITGB8))

Type de proteíne: Recombinant

Attributs du protein: AA 31-993

Origine: Macaque rhésus

Source: HEK-293 Cells

Purification/Conjugué: Cette ITGAV/ITGB8 protéine est marqué à la His tag.

Fonction: Rhesus macaque Integrin alpha V beta 8 (ITGAV & ITGB8) Heterodimer Protein

Séquence: Phe31-Pro993 (ITGAV) acidic tail & Glu43-Ser681 (ITGB8) basic tail

Specificité: Uni-Prot: F6QSK2 (ITGAV), F7F3K9 (ITGB8)

Attributs du produit: Recombinant Rhesus macaque Integrin alpha V beta 8 (ITGAV & ITGB8) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe31-Pro993(ITGAV) acidic tail & Glu43-Ser681(ITGB8) basic tail.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Biological Activity Comment: Immobilized Rhesus macaque ITGAV&ITGB8, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-alpha-v Antibody , hFc Tag with the EC50 of 56ng/ml determined by ELISA. See testing image for detail.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: ITGAV/ITGB8 (Integrin alpha V beta 8 (ITGAV/ITGB8))

Autre désignation: Integrin alpha V beta 8 (ITGAV & ITGB8) Heterodimer (ITGAV/ITGB8 Produits)

Sujet: Deletions of the genes encoding the integrin αVβ8 (Itgav, Itgb8) have been shown to result in abnormal vascular development in the CNS, including prenatal and perinatal hemorrhage. Other work has indicated that a major function of this integrin in vivo is to promote TGFβ activation.

Poids moléculaire: 112.1 kDa (ITGAV)&75.3 kDa (ITGB8). Due to glycosylation, the protein migrates to 90-140 kDa based on Tris-Bis PAGE result.

UniProt: F6QSK2