TNFSF9 Protein (AA 104-309, Extracellular Domain, Soluble) (DYKDDDDK Tag)

N° du produit ABIN5564464

Détail du produit

Antigène: TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))

Type de proteíne: Recombinant

Attributs du protein: AA 104-309, Extracellular Domain, Soluble

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette TNFSF9 protéine est marqué à la DYKDDDDK Tag.

Application: SDS-PAGE (SDS)

Specificité: Binds to mouse CD137.

Réactivité croisée: Souris

Attributs du produit: The extracellular domain of mouse CD137L (aa 104-309) is fused at the N-terminus to a FLAG®-tag.

Pureté: >95 % (SDS-PAGE)

niveau d'endotoxine: <0.01EU/μg purified protein (LAL test, Lonza).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Solid

Concentration: Lot specific

Buffer: Lyophilized. Contains PBS.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Date de péremption: 6 months

Détail du antigène

Antigène: TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))

Autre désignation: CD137L (TNFSF9 Produits)

Synonymes: TNFSF9 Protein, 4-1BB-L Protein, 4-1BBL Protein, AI848817 Protein, Cd137l Protein, Ly63l Protein, CD137L Protein, TNF superfamily member 9 Protein, tumor necrosis factor (ligand) superfamily, member 9 Protein, Tnfsf9 Protein, LOC476729 Protein, TNFSF9 Protein

Sujet: The CD137 ligand (CD137L, 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II, transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response.

Poids moléculaire: ~40kDa (SDS-PAGE)

UniProt: P41274

Pathways: Activated T Cell Proliferation, Cancer Immune Checkpoints