SIRT1 Protein (AA 254-495) (His tag)

N° du produit ABIN5853631

Détail du produit

Antigène: SIRT1 (Sirtuin 1 (SIRT1))

Type de proteíne: Recombinant

Attributs du protein: AA 254-495

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette SIRT1 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMKK IIVLTGAGVS VSCGIPDFRS RDGIYARLAV DFPDLPDPQA MFDIEYFRKD PRPFFKFAKE IYPGQFQPSL CHKFIALSDK EGKLLRNYTQ NIDTLEQVAG IQRIIQCHGS FATASCLICK YKVDCEAVRG DIFNQVVPRC PRCPADEPLA IMKPEIVFFG ENLPEQFHRA MKYDKDEVDL LIVIGSSLKV RPVALIPSSI PHEVPQILIN REPLPHLHFD VELLGDCDVI INELCHRLGG

Pureté: > 90 % by SDS - PAGE

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Denatured

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 10 % glycerol, 0.4M urea

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: SIRT1 (Sirtuin 1 (SIRT1))

Autre désignation: SIRT1 (SIRT1 Produits)

Synonymes: sirtuin 1 Protein, AA673258 Protein, SIR2L1 Protein, Sir2 Protein, Sir2a Protein, Sir2alpha Protein, sir2l1 Protein, sirtuin Protein, SIR2 Protein, sirtuin 1 Protein, sirtuin 1 L homeolog Protein, SIRT1 Protein, SRT1 Protein, Sirt1 Protein, sirt1.L Protein

Sujet: SIRT1 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. Alternative splicing results in multiple transcript variants. Recombinant human SIRT1 protein, fused to His-tag at N-terminus, was expressed in E.coli .

Poids moléculaire: 31.6 kDa (280 aa)

NCBI Accession: NP_036370

UniProt: Q96EB6

Pathways: Signalisation MAPK, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Negative Regulation of intrinsic apoptotic Signaling