RTN4R Protein (AA 27-447) (His tag)

N° du produit ABIN5854705

Détail du produit

Antigène: RTN4R (Reticulon 4 Receptor (RTN4R))

Type de proteíne: Recombinant

Attributs du protein: AA 27-447

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette RTN4R protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: CPGACVCYNE PKVTTSCPQQ GLQAVPVGIP AASQRIFLHG NRISHVPAAS FRACRNLTIL WLHSNVLARI DAAAFTGLAL LEQLDLSDNA QLRSVDPATF HGLGRLHTLH LDRCGLQELG PGLFRGLAAL QYLYLQDNAL QALPDDTFRD LGNLTHLFLH GNRISSVPER AFRGLHSLDR LLLHQNRVAH VHPHAFRDLG RLMTLYLFAN NLSALPTEAL APLRALQYLR LNDNPWVCDC RARPLWAWLQ KFRGSSSEVP CSLPQRLAGR DLKRLAANDL QGCAVATGPY HPIWTGRATD EEPLGLPKCC QPDAADKASV LEPGRPASAG NALKGRVPPG DSPPGNGSGP RHINDSPFGT LPGSAEPPLT AVRPEGSEPP GFPTSGPRRR PGCSRKNRTR SHCRLGQAGS GGGGTGDSEG SLEHHHHHH

Pureté: > 90 % by SDS - PAGE

niveau d'endotoxine: < 1.0 EU per 1 microgram of protein (determined by LAL method)

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: RTN4R (Reticulon 4 Receptor (RTN4R))

Autre désignation: RTN4R (RTN4R Produits)

Synonymes: NgR Protein, NGR Protein, NOGOR Protein, NgR1 Protein, Nogor Protein, reticulon 4 receptor Protein, rtn4r Protein, RTN4R Protein, Rtn4r Protein

Sujet: RTN4R, also known as reticulon-4 receptor, is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. It is expressed predominantly in neurons and their axons in the central nervous systems (CNS). It may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer's disease (AD). It may play a role in regulating the function of the gap junctions. Recombinant human RTN4R, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Poids moléculaire: 46.3kDa (429aa) 40-57kDa (SDS-PAGE under reducing conditions)

NCBI Accession: NP_075380

UniProt: Q9BZR6

Pathways: Neurotrophin Signaling Pathway