IL1R2 Protein (AA 14-343) (His tag)
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- Antigène Voir toutes IL1R2 Protéines
- IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 14-343
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Origine
- Humain
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Source
- Baculovirus infected Insect Cells
- Purification/Conjugué
- Cette IL1R2 protéine est marqué à la His tag.
- Application
- SDS-PAGE (SDS)
- Séquence
- FTLQPAAHTG AARSCRFRGR HYKREFRLEG EPVALRCPQV PYWLWASVSP RINLTWHKND SARTVPGEEE TRMWAQDGAL WLLPALQEDS GTYVCTTRNA SYCDKMSIEL RVFENTDAFL PFISYPQILT LSTSGVLVCP DLSEFTRDKT DVKIQWYKDS LLLDKDNEKF LSVRGTTHLL VHDVALEDAG YYRCVLTFAH EGQQYNITRS IELRIKKKKE ETIPVIISPL KTISASLGSR LTIPCKVFLG TGTPLTTMLW WTANDTHIES AYPGGRVTEG PRQEYSENNE NYIEVPLIFD PVTREDLHMD FKCVVHNTLS FQTLRTTVKE LEHHHHHH
- Pureté
- > 90 % by SDS - PAGE
- niveau d'endotoxine
- < 1.0 EU per 1ug of protein (determined by LAL method)
- Biological Activity Comment
- Measured by its ability to inhibit proliferation using D10.G4.1 mouse helper T cells. The ED50 for this effect is less or equal to 400 ng/ml with IL-1beta.
- Top Product
- Discover our top product IL1R2 Protéine
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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Bioactivity Validated
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Liquid. In Phosphate Buffered Saline ( pH 7.4) containing 10 % glycerol.
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Antigène
- IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))
- Autre désignation
- IL1R2 (IL1R2 Produits)
- Synonymes
- CD121b Protein, CDw121b Protein, IL-1R-2 Protein, IL-1RT-2 Protein, IL-1RT2 Protein, IL1R2c Protein, IL1RB Protein, Il1r-2 Protein, IL-1R2 Protein, interleukin 1 receptor type 2 Protein, interleukin 1 receptor, type II Protein, interleukin-like Protein, IL1R2 Protein, Il1r2 Protein, KK34 Protein
- Sujet
- IL1R2, also known as interleukin-1 receptor type 2 isoform 1, is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is expressed predominantly by, T cells, fibroblasts and endothelial cells. It binds interleukin-1 alpha (IL1A), interleukin-1beta (IL1B), and interleukin 1 receptor antagonist (IL1RN), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling. Also, Interleukin-4 (IL4) is reported to antagonize the activity of interleukin-1 by inducing the expression and release of this cytokine. Recombinant human IL1R2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
- Poids moléculaire
- 38.8kDa (338aa) 40-57kDa (SDS-PAGE under reducing conditions)
- NCBI Accession
- NP_004624
- UniProt
- P27930
- Pathways
- Signalisation NF-kappaB
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