RAD23A Protein (AA 2-201, partial) (GST tag)

N° du produit ABIN618825

Détail du produit

Antigène: RAD23A (RAD23 Homolog A (RAD23A))

Type de proteíne: Recombinant

Attributs du protein: AA 2-201, partial

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette RAD23A protéine est marqué à la GST tag.

Application: SDS-PAGE (SDS), ELISA, Western Blotting (WB)

Séquence: AVTITLKTLQ QQTFKIRMEP DETVKVLKEK IEAEKGRDAF PVAGQKLIYA GKILSDDVPI RDYRIDEKNF VVVMVTKTKA GQGTSAPPEA SPTAAPESST SFPPAPTSGM SHPPPAARED KSPSEESAPT TSPESVSGSV PSSGSSGREE DAASTLVTGS EYETMLTEIM SMGYERERVV AALRASYNNP HRAVEYLLTG

Pureté: 95 %

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS buffer, 20mM GSH

Stock: 4 °C

Détail du antigène

Antigène: RAD23A (RAD23 Homolog A (RAD23A))

Autre désignation: UV excision repair protein RAD23 homolog A (RAD23A Produits)

Synonymes: rad23a Protein, wu:fe11h06 Protein, zgc:92001 Protein, RAD23A Protein, HHR23A Protein, HR23A Protein, 2310040P19Rik Protein, AL024030 Protein, mHR23A Protein, RAD23 homolog A, nucleotide excision repair protein a Protein, RAD23 homolog A, nucleotide excision repair protein Protein, rad23aa Protein, RAD23A Protein, Rad23a Protein

Sujet: Background: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Ref.6 Ref.9 Ref.10 Ref.11 Ref.20 Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC. Ref.6 Ref.9 Ref.10 Ref.11 Ref.20 Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome. Synonyms: Short name=HR23A Short name=hHR23A

Poids moléculaire: 48.8 kD

NCBI Accession: NM_005053

UniProt: P54725

Pathways: Réparation de l'ADN