GCK Protein (His tag)

N° du produit ABIN668035

Détail du produit

Antigène: GCK (Glucokinase (Hexokinase 4) (GCK))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette GCK protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Attributs du produit: Hexokinase 4 Human, His-tagged, Recombinant, E.coli

Pureté: > 95 % by SDS - PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl pH8.0, 10% glycerol.

Stock: 4 °C

Détail du antigène

Antigène: GCK (Glucokinase (Hexokinase 4) (GCK))

Autre désignation: Hexokinase 4 (GCK Produits)

Synonymes: FGQTL3 Protein, GK Protein, GLK Protein, HHF3 Protein, HK4 Protein, HKIV Protein, HXKP Protein, LGLK Protein, MODY2 Protein, Gk Protein, Gls006 Protein, GCK Protein, BA4487 Protein, glk Protein, hk4 Protein, hhf3 Protein, hkiv Protein, hxkp Protein, gck-A Protein, mody2 Protein, glucokinase Protein, GLUKA Protein, RNGK2 Protein, glucokinase Protein, glucokinase (hexokinase 4) L homeolog Protein, glucokinase (hexokinase 4) Protein, GCK Protein, Gck Protein, glcK Protein, Bphyt_1025 Protein, Halhy_6548 Protein, gk Protein, gck.L Protein, gck Protein

Sujet: Hexokinase is the first enzyme in the glycolytic pathway, catalyzing the transfer of a phosphoryl group from ATP to glucose to form glucose-6-phosphate and ADP. In mammals, four distinct enzymes-types 1 to 4 hexokinases-have been identified. The enzyme is found in most cells, but there is tissue specificity for the particular type of hexokinase. Hexokinase4 is found in the liver and pancreatic beta-cells, where it is controlled by insulin (activation) and glucagon (inhibition). In pancreatic beta-cells, type IV enzyme acts as a glucose sensor to modify insulin secretion. Hexokinase4 is commonly called ‘glucokinase’. Recombinant human Hexokinase4, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: GCK, Hexokinase 4, EC 2.7.1.2, Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D, Glucokinase, ATP D hexose 6 phosphotransferase, GK, GLK, Glucokinase, Glucokinase isoform 1, Hexokinase 4, Hexokinase D, Hexokinase D pancreatic isozyme, Hexokinase4, HexokinaseD, HHF 3, HHF3, HK 4, HXKP, Maturity onset diabetes of the young 2, MODY 2, MODY2. NCBI no.: NP_000153

Poids moléculaire: 54.3kDa (485aa)

Pathways: Signalisation MAPK, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process