EGFRviii Protein (AA 25-378) (His tag,FITC)

N° du produit ABIN6973043

Détail du produit

Antigène: EGFRviii (EGFRv3) (EGFR vIII (EGFRv3))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 25-378

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette EGFRviii protéine est marqué à la His tag,FITC.

Attributs du produit: FITC-Labeled Human EGFRvIII Protein, His Tag

Pureté: >90 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Détail du antigène

Antigène: EGFRviii (EGFRv3) (EGFR vIII (EGFRv3))

Autre désignation: EGFRvIII (EGFRv3 Produits)

Sujet: The epidermal growth factor receptor (EGFR, ErbB-1, HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. The type III EGF deletion-mutant receptor (EGFRvIII) is the most common mutation and was first identified in primary human glioblastoma tumors, EGFR gene amplification is correlated with the structural rearrangement of the gene. The EGFRvIII gene has an in-frame deletion of 801 base pairs, corresponding to exons 2-7 in the mRNA, resulting in the deletion of amino acids 30-297 in the extracellular domain and the generation of a glycine at the fusion point

Poids moléculaire: 40.5 kDa

NCBI Accession: NP_001333870