EGFRviii Protein (Alexa Fluor 488,His tag)

N° du produit ABIN7482319

Détail du produit

Antigène: EGFRviii (EGFRv3) (EGFR vIII (EGFRv3))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette EGFRviii protéine est marqué à la Alexa Fluor 488,His tag.

Fonction: Alexa Fluor™ 488-Labeled Human EGFRvIII Protein, His TagStar Staining

Séquence: Leu 25 - Ser 378

Attributs du produit: Alexa Fluor 488-Labeled Human EGFRvIII, His Tag is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Ser 378 (Accession # NP_001333870.1).

Pureté: 90 %

niveau d'endotoxine: 1.0 EU per μg

Information d'application

Commentaires:

This protein carries a polyhistidine tag at the C-terminus. (AF488 ,10xHis) The protein has a calculated MW of 53.0 kDa.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Stockage commentaire: -20°C, avoid light

Détail du antigène

Antigène: EGFRviii (EGFRv3) (EGFR vIII (EGFRv3))

Autre désignation: EGFRvIII (EGFRv3 Produits)

Sujet: The epidermal growth factor receptor (EGFR, ErbB-1, HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. The type III EGF deletion mutant receptor (EGFRvIII) is the most common mutation and was first identified in primary human glioblastoma tumors. This tumor-specific antigen is ligand-independent, contains a constitutively active tyrosine kinase domain, and has been shown to be present in a number of human malignancies. EGFRvIII has been selected as a target for CAR-modified T-cell studies in recent years.

Poids moléculaire: 53.0 kDa