NOTCH3 Protein (AA 40-467) (Fc Tag)

N° du produit ABIN6992329

Détail du produit

Antigène: NOTCH3 (Notch 3 (NOTCH3))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 40-467

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette NOTCH3 protéine est marqué à la Fc Tag.

Fonction: Human NOTCH3 Protein, Fc Tag

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5

Stock: -20 °C

Détail du antigène

Antigène: NOTCH3 (Notch 3 (NOTCH3))

Autre désignation: NOTCH3 (NOTCH3 Produits)

Synonymes: CADASIL Protein, CASIL Protein, IMF2 Protein, AW229011 Protein, N3 Protein, hpbk Protein, fa14b08 Protein, notch5 Protein, wu:fa14b08 Protein, notch 3 Protein, NOTCH3 Protein, Notch3 Protein, notch3 Protein

Sujet: Notch3 is one of four mammalian Notch proteins, which act as signalling receptors and involve in developmental patterning, cell fate decisions, regulation of cell survival and proliferation. Notch3 could interact with membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Via ligand activation, notch intracellular domain (NICD) is released and forms a transcriptional activator RBPJ/RBPSUH complex, which activates genes of the enhancer of split locus. Consequently, the activation of Notch3 can lead to the implementation of differentiation, proliferation and apoptotic programs

Poids moléculaire: 71.4 kDa

NCBI Accession: NP_000426

Pathways: Signalisation Notch