Syndecan 1 Protein (SDC1) (His tag)

N° du produit ABIN7320206

Cette protéine Recombinant Syndecan 1 est produite dans HEK-293 Cells.

Aperçu rapide pour Syndecan 1 Protein (SDC1) (His tag) (ABIN7320206)

Antigène: Syndecan 1 (SDC1)

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Pureté: > 80 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette Syndecan 1 protéine est marqué à la His tag.

Fonction: Recombinant Mouse Syndecan-1/SDC1 Protein (His Tag)

Séquence: Met 1-Glu 252

Attributs du produit: A DNA sequence encoding the extracellular domain of mouse SDC1 (NP_035649.1) (Met 1-Glu 252) was expressed, with a C-terminal polyhistidine tag.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Syndecan 1 (SDC1)

Autre désignation: Syndecan-1/SDC1

Sujet: AA408134,AA409076,CD138,Sstn,Synd,Synd1,syn-1,Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.

Poids moléculaire:

Calculated MW: 26 kDa

Observed MW: 45-60 kDa

ID gène: 20969

NCBI Accession: NP_035649

UniProt: P18828

Pathways: Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Lipid Metabolism