TLR4 Protein (His tag)

N° du produit ABIN7318006

Détail du produit

Antigène: TLR4 (Toll-Like Receptor 4 (TLR4))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette TLR4 protéine est marqué à la His tag.

Fonction: Recombinant Human TLR4/CD284 Protein (His Tag)

Séquence: Met 1-Lys631

Attributs du produit: A DNA sequence encoding the human TLR4 (Met 1-Lys631) (O00206-1) was expressed, with a C-terminal polyhistidine tag.

Pureté: > 87 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: TLR4 (Toll-Like Receptor 4 (TLR4))

Autre désignation: TLR4/CD284 (TLR4 Produits)

Synonymes: ARMD10 Protein, CD284 Protein, TLR-4 Protein, TOLL Protein, Lps Protein, Ly87 Protein, Ran/M1 Protein, Rasl2-8 Protein, toll like receptor 4 Protein, toll-like receptor 4 Protein, TLR4 Protein, Tlr4 Protein

Sujet:

Background: TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. TLR4 is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. TLR 4 has also been designated as CD284 (cluster of differentiation 284). It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). It acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. It is also involved in LPS-independent inflammatory responses triggered by Ni(2+).

Synonym: ARMD10,CD284,TLR-4,TLR4,TOLL

Poids moléculaire: 70.5 kDa

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins