MPL Protein (Fc Tag)

N° du produit ABIN7490615

Détail du produit

Antigène: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette MPL protéine est marqué à la Fc Tag.

Fonction: Recombinant Human c-MPL with C-terminal human Fc tag

Specificité: C-MPL (Gln26-Ala490) hFc (Glu99-Ala330)

Attributs du produit: Extracellular Domain Protein

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Autre désignation: c-MPL (MPL Produits)

Synonymes: C-MPL Protein, CD110 Protein, MPLV Protein, THCYT2 Protein, TPOR Protein, TPO-R Protein, c-mpl Protein, c-mpl-I Protein, c-mpl-II Protein, hlb219 Protein, MPL Protein, mpll Protein, tpor Protein, tpor.b Protein, MPL proto-oncogene, thrombopoietin receptor Protein, myeloproliferative leukemia virus oncogene Protein, MPL Protein, Mpl Protein, mpl Protein

Sujet: C-MPL, CD110, MPLV, THCYT2, THPOR, TPORIn 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation.
Description: The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008]

Poids moléculaire: predicted molecular mass of 78.5 kDa after removal of the signal peptide.The apparent molecular mass of c-MPL-hFc is 100-130 kDa due to glycosylation.

UniProt: P40238

Pathways: Signalistation JAK/STAT