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anti-Human ATP12A Anticorps:
anti-Mouse (Murine) ATP12A Anticorps:
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Human Polyclonal ATP12A Primary Antibody pour IHC, IHC (p) - ABIN4282228
Wang, Barbuskaite, Tozzi, Giannuzzo, Sørensen, Novak: Proton Pump Inhibitors Inhibit Pancreatic Secretion: Role of Gastric and Non-Gastric H+/K+-ATPases. dans PLoS ONE 2015
ATP12A knockdown or inhibition prevented the IL-13 dependent increase in airway surface liquid (ASL) viscosity but did not alter the ASL pH
expressing human ATP12A in cystic fibrosis mouse airways acidified airway surface liquid, impaired defenses, and increased airway bacteria.
Genetic association studies show that carriers of ATP12A rs10507337 C allele or CCTTC haplotype had better pattern of myocardial relaxation as compared to non-carriers.
No significantly different expression levels could be detected in the various disease states compared to normal tissue.
The presence of nongastric H-K-ATPase in rodent prostate apical membranes may indicate its involvement in potassium concentration regulation in secretions of these glands.
Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1.
Expressed in distal part of human colon and rectum, but also in proximal part of colon. Overexpressed in human colorectal adenocarcinomas adenocarcinomas. Astonishing levels of mRNA overexpression in carcinoma.
Carboxy-terminus of HKalpha(2) facilitates proper folding of tHKalpha(2)/beta(1) complex allowing translocation of heterodimer to plasma membrane where potassium uptake occurs. Otherwise, alpha/beta complex is destined for degradation.
non-gastric H(+)/K(+)ATPase is present in the microvillous plasma membrane of the transporting epithelia of the human placenta
Inhibition of the ATP1AL1 isoenzyme of sodium potassium exchanging ATPase by 8-coumestrol is reported.
Use of fold recognition methods enables a prediction that the C-terminal domain of the beta subunits of Na,K-ATPase and H,K-ATPase has an immunoglobulin-like fold, which resembles cell adhesion molecules.
After 4 days of K+ restriction HKA2 KO mice exhibit hypokalemia and hypotension.
HKA2-null mice did not accumulate K(+) in their extracellular compartment.
HKA2-null mice fed a normal diet have 2-fold higher K(+) renal excretion during rest. Under K(+) restriction, their urinary K(+) loss is 40% higher during the activity period.
kappaB DNA binding element at -104 to -94 influences basal HKalpha(2) gene transcription in kidney collecting duct cells
These results show that nongastric H-K-ATPase is required for acidification of luminal prostate fluids, thereby providing a strong in vivo correlate of previous functional expression studies demonstrating that it operates as a proton pump.
Both HKalpha(1) and HKalpha(2) contribute to proton secretion in both A-type and B-type intercalated cells in animals fed a normal diet.
Sp1 plays an important and positive role in controlling basal HKalpha2 gene expression in murine inner medullary collecting duct cells in vivo and in vitro.
The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene.
ATPase, Na+/K+ transporting, alpha polypeptide-like 1
, non-gastric H(+)/K(+) ATPase alpha subunit
, non-gastric H(+)/K(+) ATPase subunit alpha
, potassium-transporting ATPase alpha chain 2
, proton pump
, ATPase H+K+-transporting, alpha 2
, H-K-ATPase alpha 2
, hydrogen/potassium-exchanging ATPase 12A
, H+,K+ -ATPase alpha subunit
, H+,K+-ATPase alpha 2 subunit
, H+,K+-ATPase alpha 2c subunit
, H,K-ATPase alpha2 subunit
, HK alpha 2