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anti-Human XRCC1 Anticorps:
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Human Polyclonal XRCC1 Primary Antibody pour ICC, IF - ABIN151964
Iles, Rulten, El-Khamisy, Caldecott: APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. dans Molecular and cellular biology 2007
Show all 3 Pubmed References
TGFB1 T10C and XRCC1 G399A SNPs were associated with CC risk in univariate and multivariate analysis and displayed allele-dosage effects and coselection in cancer patients. Patients harboring the majority allele TGFB1 T10 (Leu) or the variant allele XRCC1 399A (Gln) have approximately 1.5-fold increased risk to develop CC.
HOGG1 Ser326Cys, APE1 (Montrer APEX1 Anticorps) Asp148Glu and XRCC1 Arg399Gln polymorphisms are correlated with the risk and clinicopathological features of PACG.
The current meta-analysis indicated that the XRCC1 Arg399Gln polymorphism decreased the risk of cervical cancer, while the Arg194Trp and Arg280His polymorphisms were not associated with cervical caner risk. [meta-anlalysis]
On univariate analysis, a statistically significant association was found between risk of hepatocellular carcinoma(HCC) and XRCC1 399Arg/Gln genotype.To our knowledge, this is the first study reporting an association between base excision repair SNP and hepatocellular carcinoma risk in a population of central-southern Italy.
This meta-analysis suggested that the XRCC1 Arg399Gln polymorphism was a risk factor for cutaneous melanoma in population-based subgroup.
We demonstrated that infants whose mothers smoked during pregnancy with the combination of AHR (Montrer AHR Anticorps), CYP1A1 (Montrer CYP1A1 Anticorps), and XRCC1 polymorphisms had lower birth size.
Study suggested that RAD51 (Montrer RAD51 Anticorps), XRCC1, and XRCC3 (Montrer XRCC3 Anticorps) polymorphisms may be predictive factors for radiation-induced acute toxicity in rectal cancer patients treated with preoperative combined therapy.
Allelic variants in ERCC1 and ERCC2 are not associated with an increased risk of developing pre-senile cataract. The presence of Gln/Gln in XRCC1 in the pre-senile cataract group with regard to the group without cataract is associated with a major risk of developing pre-senile cataract.
XRCC1 Arg399Gln Gln/Gln genotype, Gln allele, and homozygote variants of XRCC3 Thr241Met polymorphism may be a risk factor for predisposition of Oral Squamous Cell Carcinoma in Turkish. In addition, XRCC3 Thr241Met genotype could be associated with tumor size and level of daily smoking.
XRCC1 polymorphism is associated with colorectal cancer.
this review focuses on the role of the oxidized form of XRCC1 in protection against extreme oxidative stress
Repair independent of the well documented XRCC1-PNKP (Montrer PNKP Anticorps) interaction was studied. XRCC1 can mediate repair of strand breaks without PNKP (Montrer PNKP Anticorps) binding.
data establish the importance of XRCC1 protein complexes for normal neurological function and identify PARP1 (Montrer PARP1 Anticorps) as a therapeutic target in DNA strand break repair-defective disease
We have characterized the nuclear localization signal (NLS (Montrer ALDH1A2 Anticorps)) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging.
Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1 (Montrer OGG1 Anticorps), Neil1 (Montrer NEIL1 Anticorps), Mutyh (Montrer MUTYH Anticorps) and Xrcc1 in the brain of adult offspring.
In cells with DNA base damage, PAR (Montrer AFG3L2 Anticorps) serves to recruit XRCC1 that in turn binds and recruits pol beta (Montrer POLB Anticorps), the primary DNA polymerase (Montrer POLB Anticorps) of the base excision repair pathway.
Lig4 (Montrer LIG4 Anticorps) and XRCC1 double-deficient cells switch as efficiently as Lig4 (Montrer LIG4 Anticorps)-deficient cells, clearly indicating that XRCC1 is dispensable for A-EJ in CH12F3 cells during class switch recombination
findings firmly demonstrate that XRCC1 is not a requisite factor for A-EJ of chromosomal DSBs and raise the possibility that DNA ligase 1 (Lig1 (Montrer LIG1 Anticorps)) may contribute more to A-EJ than previously considered
Data support a role for XRCC1 in microhomology-mediated joining, and imply that AID-induced single-strand breaks in Igh variable and switch regions become substrates simultaneously for BER and mutagenesis pathways.
Results indicates that XRCC1 haploinsufficiency has little effect on chronological longevity and many key biological markers of aging, but may adversely affect normal animal development or increase disease susceptibility to a relevant genotoxic exposure.
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
X-ray repair complementing defective repair in Chinese hamster cells 1
, X-ray repair cross complementing protein 1
, DNA repair protein XRCC1-like
, DNA repair protein XRCC1
, X-ray repair cross-complementing protein 1
, X-ray-repair, complementing defective, repair in Chinese hamster
, x-ray repair cross-complementing group 1 protein