Aperçu des produits pour anti-Chemokine (C-C Motif) Ligand 13 (CCL13) Anticorps

Human Chemokine (C-C Motif) Ligand 13 (CCL13) interaction partners

1. In plasma, but not CSF (Montrer CSF2 Anticorps), the bivariate MCP4 (CCL13)/ MCP1(CCL2 (Montrer CCL2 Anticorps)) ratio is ca. twofold elevated in PTSD patients compared with healthy controls.

2. CCL13 expression is significantly upregulated in human masticatory mucosa during wound healing

3. The reduction of circulating levels of MCP-4, eotaxin-3 (Montrer CCL26 Anticorps), and MIP-1beta (Montrer CCL4 Anticorps) could be one of the mechanisms by which bariatric surgery contributes to the reduction of cardiovascular risk in these patients.

4. CCL13 levels in serum and synovial fluid may serve as a biomarker for the progression of osteoarthritis.

5. identified 13 ADCC-activated genes. Six gene expression assays including 8 of the 13 genes (CCL3 (Montrer CCL3 Anticorps), CCL4/CCL4L1 (Montrer CCL4 Anticorps)/CCL4L2, CD160 (Montrer CD160 Anticorps), IFNG (Montrer IFNG Anticorps), NR4A3 (Montrer NR4A3 Anticorps) and XCL1 (Montrer XCL1 Anticorps)/XCL2 (Montrer XCL2 Anticorps)) were analyzed in 127 kidney biopsies

6. CCL13 is an antimicrobial protein with bacteriocidal activity against E. coli.

7. Data suggest that CCL13 binds to several chemokine (Montrer CCL1 Anticorps) receptors (CCR1, CCR2 (Montrer CCR2 Anticorps), and CCR3 (Montrer CCR3 Anticorps)), allowing CCL13 to elicit different effects on target cells of immune system. CCL13 is involved in pathology of chronic inflammatory/autoimmune diseases. [REVIEW]

8. MCP-4 and hsCRP may be the markers linking chronic inflammation in obesity and periodontal disease.

9. E(2) has adverse effects on the pathogenesis of RA as a result of unregulated cell death, increased TNF-alpha (Montrer TNF Anticorps)-induced MMP-3 (Montrer MMP3 Anticorps) production, and CCL13 overproduction, subsequently resulting in the disease progression of RA.

10. Data show that, for the small macrophages in COPD (Montrer ARCN1 Anticorps), increased transcript and protein levels for CCL2 (Montrer CCL2 Anticorps), CCL7 (Montrer CCL7 Anticorps), CCL13 and CCL22 (Montrer CCL22 Anticorps) with a more than 100-fold increase for CCL13 mRNA.

Mouse (Murine) Chemokine (C-C Motif) Ligand 13 (CCL13) interaction partners

1. deletion of the gene encoding MMCP-4 (Mcpt4), markedly reduced late, but not early, infarct size by suppressing IGF-1 (Montrer IGF1 Anticorps) degradation and, consequently, diminished cardiac dysfunction and adverse structural remodeling

2. Data indicate that a second-degree burn injury can initiate an immediate novel zonal degranulation of mast cell throughout all skin layers and a disruption of the epidermal tight junctions dependent on the nonredundant presence of mMCP4 and mMCP5 (Montrer CMA1 Anticorps).

3. these results support the conclusion that mast cells can contribute to the initial lung injury induced by bleomycin through release of the MCPT4 chymase (Montrer CMA1 Anticorps).

4. Mast cell chymase (Montrer CMA1 Anticorps) degrades the alarmins heat shock protein 70 (Montrer HSP70 Anticorps), biglycan (Montrer BGN Anticorps), HMGB1 (Montrer HMGB1 Anticorps), and interleukin-33 (IL-33 (Montrer IL33 Anticorps)) and limits danger-induced inflammation.

5. Data from Mcp-4 (mast cell protease 4) knockout mice suggest Mcp-4 plays a pivotal role in the dynamic (in vivo and in vitro) conversion of systemic Big-endothelin-1 (Montrer EDN1 Anticorps) to endothelin-1 (Montrer EDN1 Anticorps) (1-31).

6. MCs (Montrer SMCP Anticorps) exert protective functions after trauma, at least in part via mMCP-4, by suppressing exacerbated inflammation via their proteases.

7. The effects of interactions between mMCP-4 and TNF (Montrer TNF Anticorps) in vivo by analyzing the features of a classic model of polymicrobial sepsis, were assessed.

8. mMCP-4 plays two different roles in the pathogenesis of experimental BP, by both activating MMP-9 (Montrer MMP9 Anticorps) and by cleaving BP180 (Montrer COL17A1 Anticorps), leading to injury of the hemidesmosomes and extracellular matrix of the basement membrane zone.

9. mMCP-4-deficient mice but not to mMCP-5 (Montrer CMA1 Anticorps)-deficient mice revealing nonredundant actions for these two MC proteases in a model of innate inflammatory injury with remodeling.

10. MCP-4 contributes locally to the aggravation of glomerulonephritis by mediating a variety of proinflammatory effects.