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anti-Human GABRB3 Anticorps:
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Mammalian Monoclonal GABRB3 Primary Antibody pour ISt, IHC - ABIN1304646
Marty, Vlkolinsky, Minassian, Cohen, Nelson, Spigelman: Radiation-induced alterations in synaptic neurotransmission of dentate granule cells depend on the dose and species of charged particles. dans Radiation research 2014
Show all 21 Pubmed References
Human Polyclonal GABRB3 Primary Antibody pour IF, IHC - ABIN152540
Slany, Zezula, Tretter, Sieghart et al.: Rat beta 3 subunits expressed in human embryonic kidney 293 cells form high affinity [35S]t-butylbicyclophosphorothionate binding sites modulated by several allosteric ligands of gamma-aminobutyric ... dans Molecular pharmacology 1995
Show all 7 Pubmed References
Mouse (Murine) Polyclonal GABRB3 Primary Antibody pour WB - ABIN550211
McKernan, Rosahl, Reynolds, Sur, Wafford, Atack, Farrar, Myers, Cook, Ferris, Garrett, Bristow, Marshall, Macaulay, Brown, Howell, Moore, Carling, Street, Castro, Ragan, Dawson, Whiting: Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype. dans Nature neuroscience 2000
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Mouse (Murine) Monoclonal GABRB3 Primary Antibody pour ICC, IF - ABIN4313074
Schwirtlich, Kwakowsky, Emri, Antal, Lacza, Cselenyák, Katarova, Szabó: GABAergic signaling in primary lens epithelial and lentoid cells and its involvement in intracellular Ca2+ modulation. dans Cell calcium 2011
Rat (Rattus) Polyclonal GABRB3 Primary Antibody pour ICC, IHC - ABIN1742465
Kerti-Szigeti, Nusser, Eyre: Synaptic GABAA receptor clustering without the ?2 subunit. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Rat (Rattus) Polyclonal GABRB3 Primary Antibody pour WB - ABIN4313075
Bohnsack, Carlson, Morrow: Differential regulation of synaptic and extrasynaptic α4 GABA(A) receptor populations by protein kinase A and protein kinase C in cultured cortical neurons. dans Neuropharmacology 2016
Polyclonal GABRB3 Primary Antibody pour ELISA - ABIN539692
Tanaka, Olsen, Medina, Schwartz, Alonso, Duron, Castro-Ortega, Martinez-Juarez, Pascual-Castroviejo, Machado-Salas, Silva, Bailey, Bai, Ochoa, Jara-Prado, Pineda, Macdonald, Delgado-Escueta: Hyperglycosylation and reduced GABA currents of mutated GABRB3 polypeptide in remitting childhood absence epilepsy. dans American journal of human genetics 2008
Meta-analysis indicates that neither rs4906902 nor rs20317 are significantly associated with the risk of autism spectrum disorder.
rs4906902 and rs8179184 in the 5' promoter region of GABRB3 are associated with schizophrenia in Han Chinese.
In this study, we performed exome sequencing in six patients with SCN1A-negative Dravet syndrome to identify other genes related to this disorder..the data in this study identify GABRB3 as a candidate gene for Dravet syndrome
Results indicate that GABRB3 mutations are associated with a broad phenotypic spectrum of epilepsies and that reduced receptor function causing GABAergic disinhibition represents the relevant disease mechanism
GABRB3 might be associated with heroin dependence, and increased expression of GABRB3 might contribute to the pathogenesis of heroin dependence
Findings provide genetic evidence for the involvement of the genes GABRB3 and GABRA5 in the susceptibility to panic disorder
Increased GABRB3 expression may confer an increased risk of schizophrenia.
1,2-dichlorohexafluorocyclobutane enhancement of GABRA5 activity is abolished by GABRB3 mutations.
Propofol, AziPm, and o-PD Inhibit [3H]Azietomidate and R-[3H]mTFD-MPAB Photolabeling of alpha1beta3 GABAAR.
Considering our Argentinean ASD sample, it can be inferred that GABRB3 would be involved in the etiology of autism through interaction with GABRD. These results support the hypothesis that GABAR subunit genes are involved in autism.
Data suggest that GABA(A) receptor subunits (alpha-1 and beta-3) are able to form homologous receptors with either delta (extrasynaptic) or gamma-2 subunits (synaptic); allosteric modulation appears similar in the presence of agonist etomidate.
Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human alpha1beta3gamma2 gamma-aminobutyric acid type A (GABAA) receptor.
With a weak association, data do not support the hypothesis that the GABRB3 variants are a cause of nonsyndromic cleft lip and/or palate
results provide additional evidence that GABRB3 and MAOB/NDP gene regions might constitute risk factors for hallucinations and delusions in schizophrenia.
The haplotype of C-A in rs4906902 and rs8179184 loci in the promoter of GABRB3 gene may be maternally inherited and positively associated with schizophrenia.
Our data suggest the K289M mutation in gamma2 confers GABA(A)Rs with enhanced sensitivity of their membrane diffusion to neuronal activity
In comparison to healthy donors, chronic hepatitis C patients were found to present an increase in the expression of gamma-aminobutyric acid A receptor alpha1 subunit and a decrease in the expression of beta3 subunit in their blood mononuclear leukocytes.
Our results suggest both a mechanism for mutation-induced hyperexcitability and a novel role for the GABRB3 subunit N-terminal alpha-helix in receptor assembly and gating.
Photoaffinity labeling and pepetide mapping data suggest that a homologous etomidate/general anesthetic binding site exists at the beta3-beta3 subunit interface in alpha1beta3 GABA receptor type A, specifically involving beta3-Met227.
Gaba (A) beta1 and beta3 receptor subunit mRNA levels in the dorsolateral prefrontal cortex are not altered in schizophrenia.
These results suggest that impairment in GABRB3 downregulates OCA2 and indirectly causes ocular hypopigmentation and visual defects in Angelman syndrome (AS) and Prader-Willi syndrome
In Gabrb3 mutant cerebellar nuclei cells, inhibitory postsynaptic current kinetics were unchanged, but mutant males, unlike females, showed enlarged glutamine receptor 1/5 responses and accelerated spontaneous firing.
Dysregulation of fragile X mental retardation protein-metabotropic glutamate receptor 5 signaling pathway, accompanied with a downregulation of GABA(A) receptor beta3 subunit expression, may contribute to the 'autistic-like' features knockout mice.
a mouse model demonstrates that alterations in phosphorylation and/or activity of beta3-containing GABAARs may directly contribute to the pathophysiology of autism spectrum disorders
The data presented here support the hypothesis that alpha5beta3-GABAARs underlie tonic inhibition in hippocampal CA1 pyramidal cells
These studies identify a novel gephyrin-binding motif in GABA(A) R beta2 and beta3 large cytoplasmic loops.
Data indicate that the expression levels of [beta]2/3 GABAAR showed 2.81 +/- 0.08-fold and 3.83 +/- 0.07-fold increases, respectively, in the pancreatectomized mice 3 and 14 days after surgery.
It was show nthat activation of L-type voltage-gated Ca2+ channels leads to Ca2+/calmodulin-dependent protein kinase II phosphorylation of S383 within the beta3 subunit of the GABAA receptor.
The endogenous sleep pathway in the hypothalamus operates through the beta1- containing GABAAR whereas inhibition of neuronal firing (anaesthesia) by low propofol doses relies on beta3- containing GABAAR.
GABA A receptor subunit beta3-deficient mice have enhanced risk preference in a probabilistic selection task that requires mice to choose between a small certain reward and a larger uncertain reward.
Suggest that forebrain Gabrb3 contributes to hippocampal-dependent memory suppression by isoflurane, but not etomidate.
Mice heterozygous for Gabrb3 exhibited an increase in seizure susceptibility and sensitivity to touch and heat.
This study demonstrated that beta(3) subunits to slow GABAergic inhibition onto pyramidal neurons and support different roles for these slow inhibitory synapses in the generation and coordination of hippocampal network rhythms.
Differential cell surface expression of GABAA receptor alpha1, alpha6, beta2 and beta3 subunits in cultured mouse cerebellar granule cells influence of cAMP-activated signalling.
morphologic alterations in the spiral ganglion and Scarpa's ganglion from gamma-aminobutyric acid A (GABA(A)) receptor beta(3) subunit null mutant mice
During non-REM sleep, substantial differences in EEG spectral power between genotypes implicate the beta 3 subunit of the GABA-A receptor in regulation of the cortical level expression of sleep states.
expression of gene is required for normal palate development
Binding to Gaba(A) brain receptors is overall lower in Gabrb3-/- knockout mice than in wild-type, especially in the hippocampus and cerebral cortex where Gabrb3-/- mice have two-thirds the binding of Gabrb3+/+ animals in an Angelman syndrome model.
Reduced expression of GABRB3 is associated with autism
The maternally-derived male heterozygote may carry a developmental modification resulting in less beta3 protein, which may reflect partial genomic imprinting of the gabrb3 gene in mice.
This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one of at least 13 distinct subunits of a multisubunit chloride channel that serves as the receptor for gamma-aminobutyric acid, the major inhibitory transmitter of the nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two genes encoding related subunits of the family. Mutations in this gene may be associated with the pathogenesis of Angelman syndrome, Prader-Willi syndrome, and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described.
gamma-aminobutyric acid (GABA) A receptor, beta 3
, gamma-aminobutyric acid receptor subunit beta-3
, gamma-aminobutyric acid A receptor beta 3
, gamma-aminobutyric acid receptor subunit beta-3-like
, GABA-alpha receptor beta-2 subunit
, GABAA receptor beta-3 subunit
, GABA(A) receptor subunit beta-3
, Gamma-aminobutyric acid receptor beta 3
, gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3
, gamma-aminobutyric acid receptor, subunit beta 3
, testis gamma-aminobutyric acid receptor subunit beta 3
, GABA-A receptor beta-3 subunit
, cleft palate 1