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anti-Human ARAF Anticorps:
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different isoforms of Araf may participate in similar developmental processes but by regulating different signaling pathways
The constitutive or induced re-localization of A-Raf to the plasma membrane compromises its ability to efficiently sequester and inactivate MST2 (Montrer STK3 Anticorps), thus rendering cells susceptible to apoptosis
This review discusses the regulation of A-Raf protein (Montrer RAF1 Anticorps) expression, and the roles of A-Raf in apoptosis and cancer, with a special focus on its role in resistance to Raf (Montrer RAF1 Anticorps) inhibitors. [review]
analysis of FGFR2 (Montrer FGFR2 Anticorps)-PPHLN1 (Montrer PPHLN1 Anticorps) fusion and ARAF mutations in intrahepatic cholangiocarcinoma
Aberrant expression of A-, B-, and C-RAF (Montrer RAF1 Anticorps), and COT (Montrer MAP3K8 Anticorps) is frequent in PTC (Montrer F9 Anticorps); increased expression of COT (Montrer MAP3K8 Anticorps) is correlated with recurrence of PTC (Montrer F9 Anticorps).
Dimerization of the kinase ARAF promotes MAPK (Montrer MAPK1 Anticorps) pathway activation and cell migration.
The study identifies somatic activating ARAF mutations in Langerhans cell histiocytosis.
Galpha12 (Montrer GNA12 Anticorps)-ARAF-ERK (Montrer EPHB2 Anticorps) pathway stimulates RFFL (Montrer RFFL Anticorps) transcription through the transcription factor c-Myc (Montrer MYC Anticorps).
show that Araf antagonizes mesendoderm induction and patterning activity of Nodal/Smad2 (Montrer SMAD2 Anticorps) signals in vertebrate embryos by directly inhibiting Smad2 (Montrer SMAD2 Anticorps) signalling
study investigated role of ARAF in cancer cell signaling and examined the role of ARAF in mediating paradoxical activation of the MAPK (Montrer MAPK1 Anticorps) pathway in cells treated with RAF (Montrer RAF1 Anticorps) inhibitors; ARAF seems to stabilize BRAF:CRAF complexes in cells treated with RAF (Montrer RAF1 Anticorps) inhibitors and regulate cell signaling in a subtle manner to ensure signaling efficiency
Ras pathway activation via EGF (Montrer EGF Anticorps) treatment induced strong binding between B-Raf (Montrer SNRPE Anticorps) and C-Raf (Montrer RAF1 Anticorps) and a low level of binding between B-Raf (Montrer SNRPE Anticorps) and A-Raf.
PKM1 interacts with A-Raf, an upstream regulator of the MEK (Montrer MDK Anticorps)/ERK (Montrer EPHB2 Anticorps) pathway, and that this interaction contributes to MEK1 (Montrer MAP2K1 Anticorps) phosphorylation by A-Raf.
A- and B-Raf (Montrer SNRPE Anticorps) ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf (Montrer RAF1 Anticorps) decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf (Montrer RAF1 Anticorps) does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF (Montrer VEGFA Anticorps) protein stability.
A-Raf promotes osteoblasts differentiation in response to mechanical stress.
DA-Raf (Montrer RAF1 Anticorps)-dependent inhibition of the Ras-ERK (Montrer EPHB2 Anticorps) signaling pathway in alveolar epithelial 2 cells is required for alveolar formation via triggering MMP2 (Montrer MMP2 Anticorps) activation followed by myofibroblast differentiation.
Expression of Araf in the mouse nucleus accumbens is modulated by a sequence variant (B2 SINE indel) in the 3' UTR (Montrer UTS2R Anticorps) of Comt (catechol-O-methyltransferase (Montrer COMT Anticorps)).
the binding of 14-3-3gamma to Raf (Montrer RAF1 Anticorps) indicates the critical role of this protein in ischemia-induced apoptosis and the changes in signal transduction in astrocytes in culture.
Raf-1 (Montrer RAF1 Anticorps) and A-Raf have a combined role in controlling physiological transient ERK (Montrer EPHB2 Anticorps) activation and in maintenance of cell cycle progression at its usual rate.
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
serine/threonine protein kinase ARAF standard form
, serine/threonine-protein kinase A-Raf
, v-raf murine sarcoma 3611 viral oncogene homolog
, v-raf murine sarcoma 3611 viral oncogene-like protein
, serine/threonine protein kinase ARAF
, serine/threonine-protein kinase A-Raf-like
, A-Raf proto-oncogene serine/threonine-protein kinase
, Oncogene ARAF1
, Ras-binding protein DA-Raf
, proto-oncogene A-Raf-1
, proto-oncogene Pks
, v-raf murine sarcoma 3611 viral oncogene homolog 1
, proto-oncogene A-Raf
, raf-related oncogene
, Raf related protein
, Ras-binding protein
, v-raf oncogene homolog 1 (murine sarcoma 3611 virus)