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anti-Human SGK1 Anticorps:
anti-Mouse (Murine) SGK1 Anticorps:
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Human Polyclonal SGK1 Primary Antibody pour IHC, IHC (p) - ABIN4353191
Wen, Wan, Ren, Zhou, Gao, Wu, Wang, Yuan, Zhou: Potassium supplementation inhibits IL-17A production induced by salt loading in human T lymphocytes via p38/MAPK-SGK1 pathway. dans Experimental and molecular pathology 2016
High SGK1 expression is associated with gastric cancer.
SGK1 was found to be essential for proliferation and survival of thyroid cancer cells harboring PI3K (Montrer PIK3CA Anticorps)-activating mutations.
miRNA-7-5p can regulate the expression of human alveolar ENaC (Montrer SCNN1A Anticorps) by targeting the mTORC2 (Montrer CRTC2 Anticorps)/SGK-1 signaling pathway.
TLR4 (Montrer TLR4 Anticorps) and C5aR (Montrer C5AR1 Anticorps) crosstalk in dendritic cells induces a core regulatory network of RSK2 (Montrer RPS6KA3 Anticorps), PI3Kbeta, SGK1, and FOXO (Montrer FOXO3 Anticorps) transcription factors.
Findings illustrate how cancer cells utilize a chromatin remodeling factor (Montrer ASH1L Anticorps) to engage a core survival pathway to support its cancerous phenotypes, and reveal new facets of MTA1 (Montrer MTA1 Anticorps)-SGK1 axis by a physiologic signal in cancer progression.
SGK1 inhibitor SI113 induced a significant reduction in endometrial cancer cells viability, as a result of induction of autophagy, apoptosis, and endoplasmic reticulum stress.
Findings show that serum and glucocorticoid-inducible kinase 1 (SGK1) protein dynamics can be an important part of intracellular signaling, directly influencing cellular response decisions.
In cancer cells resistant to PI3Kalpha (Montrer PIK3CA Anticorps) inhibition, PDK1 (Montrer PDK1 Anticorps) blockade restores sensitivity to these therapies. SGK1, which is activated by PDK1 (Montrer PDK1 Anticorps), contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2 (Montrer TSC2 Anticorps).
SGK1 promotes YAP (Montrer YAP1 Anticorps)/TAZ (Montrer TAZ Anticorps) transcriptional activity. SGK1 enhances YAP (Montrer YAP1 Anticorps)/TAZ (Montrer TAZ Anticorps) activity by upregulating YAP (Montrer YAP1 Anticorps)/TAZ (Montrer TAZ Anticorps). SGK1 is a transcriptional target of YAP (Montrer YAP1 Anticorps). SGK1 stabilizes TAZ (Montrer TAZ Anticorps) by inhibiting GSK3beta (Montrer GSK3b Anticorps).
Potassium supplementation has a blocking effect against salt-loading-induced IL-17A (Montrer IL17A Anticorps) production in T lymphocytes, and the protective effect was mediated through suppression of p38/MAPK (Montrer MAPK14 Anticorps)-SGK1 pathway.
SGK1 was found to be essential for proliferation and survival of thyroid cancer cells harboring PI3K-activating mutations.
Altered K balance in animals lacking SGK1 may reflect defects in epithelial Na channel -independent K excretion
our data suggest that renal tubular SGK1 is important in the regulation of K(+) excretion via the control of NEDD4-2 (Montrer NEDD4L Anticorps), WNK1 (Montrer WNK1 Anticorps), and ENaC (Montrer SCNN1A Anticorps)
SGK1 is similarly involved in the regulation of cell volume and cell fluid transport.
Mineralocorticoid receptor (Montrer NR3C2 Anticorps) deficiency suppresses migration and proliferation of macrophages and leads to less vascular smooth muscle cell activation. At the molecular level, MR deficiency suppresses macrophage inflammatory response via SGK1-AP1 (Montrer JUN Anticorps)/NF-kappaB (Montrer NFKB1 Anticorps) pathways.
Akt3 (Montrer AKT3 Anticorps) constitutively suppresses macropinocytosis in macrophages through a novel WNK1 (Montrer WNK1 Anticorps)/SGK1/Cdc42 (Montrer CDC42 Anticorps) pathway.
SGK1 and SGK3 (Montrer SGK3 Anticorps) are expressed in multiple microglial cell lines. SGK1 and SGK3 (Montrer SGK3 Anticorps) may play an important role in regulating microglial viability and inflammatory responses.
The data indicate that the balanced activities of two related serine/threonine kinases, AKT (Montrer AKT1 Anticorps) and SGK1, critically govern the embryo implantation process.
LEFTY2 (Montrer LEFTY2 Anticorps) regulates the expression and activity of ENaC (Montrer SCNN1A Anticorps) in endometrial epithelial cells via SGK1.
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Sgk1 variant i3
, serine/threonine protein kinase SGK
, serine/threonine-protein kinase Sgk1
, serum/glucocorticoid-regulated kinase 1
, serum and glucocorticoid-dependent protein kinase
, serum/glucocorticoid regulatory kinase
, serum- and glucocorticoid-induced kinase
, serum and glucocorticoid-regulated protein kinase