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anti-Human IKBKG Anticorps:
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Human Monoclonal IKBKG Primary Antibody pour SimWes, WB - ABIN252501
Wunderlich, Luedde, Singer, Schmidt-Supprian, Baumgartl, Schirmacher, Pasparakis, Brüning: Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis. dans Proceedings of the National Academy of Sciences of the United States of America 2008
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Human Monoclonal IKBKG Primary Antibody pour ICS - ABIN1177069
Carter, Pennington, Ungurait, Ballard: In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase. dans The Journal of biological chemistry 2003
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Human Monoclonal IKBKG Primary Antibody pour FACS, WB - ABIN252492
Harhaj, Sun: IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein. dans The Journal of biological chemistry 1999
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Human Monoclonal IKBKG Primary Antibody pour ELISA - ABIN4324315
Han, Karabiyikoglu, Kelly, Sobel, Yenari: Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental stroke. dans Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003
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Human Polyclonal IKBKG Primary Antibody pour ICC, ELISA - ABIN1002508
Li, Kang, Friedman, Tarassishin, Ye, Kovalenko, Wallach, Horwitz: Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis. dans Proceedings of the National Academy of Sciences of the United States of America 1999
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Human Monoclonal IKBKG Primary Antibody pour WB - ABIN387828
Mooster, Cancrini, Simonetti, Rossi, Di Matteo, Romiti, Di Cesare, Notarangelo, Geha, McDonald: Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene. dans The Journal of allergy and clinical immunology 2010
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Human Polyclonal IKBKG Primary Antibody pour ELISA, ICC - ABIN4324313
Sadaka, Marloie-Provost, Soumelis, Benaroch: Developmental regulation of MHC II expression and transport in human plasmacytoid-derived dendritic cells. dans Blood 2009
Human IKKgamma does not interact with mammalian Atg8-family proteins.
Data suggest the angiopoietin-like 8 (ANGPTL8)/p62 (Montrer GTF2H1 Anticorps)-IKKgamma axis as a negative feedback loop that regulates NF-kappaB (Montrer NFKB1 Anticorps) activation, and extends the role of selective autophagy in fine-tuned inflammatory responses.
this study demonstrates immunodeficiency in two female patients with Incontinentia Pigmenti with heterozygous NEMO mutation diagnosed by lipopolysaccharide unresponsiveness
GSK-3beta is critically important for ordered NF-kappaB (Montrer NFKB1 Anticorps) signalling through modulation of NEMO phosphorylation.
HOTAIR operates the action of IKKalpha (Montrer CHUK Anticorps), IKKbeta (Montrer IKBKB Anticorps), IKKgamma in liver cancer stem cells
the present study found that loss of the NEMO-SHARPIN (Montrer SHARPIN Anticorps) interaction impaired recruitment of truncated NEMO forms into punctuate structures that are transiently formed on cell stimulation and thus led to a defect in linear ubiquitination
NEMO was critically involved in the cGAS-STING pathway.
Results show that NEMO's expression is regulated by ASAP3 (Montrer ASAP3 Anticorps) which it interacts directly with it reducing its poly-ubiquitinylation.
E+P treatment of breast cancer cells increased ER binding to the NEMO promoter, thereby increasing NEMO expression.
Hematopoietic stem cell transplantation can cure most clinical features of patients with a variety of IKBKG mutations.
NEMO deficiency hampered activation of IKK (Montrer CHUK Anticorps) complex in osteoclast precursors, causing arrest of osteoclastogenesis and apoptosis. Interestingly, inhibiting apoptosis by genetic ablation of TNFr1 (Montrer TNFRSF1A Anticorps) significantly increased cell survival, but failed to rescue osteoclastogenesis or reverse osteopetrosis (Montrer CSF1 Anticorps).
This study provides evidence for a protective function of canonical IKK (Montrer CHUK Anticorps)/NF-kappaB (Montrer NFKB1 Anticorps) signalling in the arenchymal compartment during pancreatitis. In the absence of the regulatory IKK (Montrer CHUK Anticorps) subunit NEMO, a combination of a fibrogenic gene signature, enhanced acinar-ductal metaplasia and a lack of regeneration contribute to the exacerbation of pancreatitis.
robust caspase (Montrer CASP3 Anticorps) activation in NEMO-deficient cells is concomitant with RIPK3 (Montrer RIPK3 Anticorps) recruitment to the apoptosis-mediating complex.
lymphocyte-specific deletion of IKK2 (Montrer IKBKB Anticorps) or NEMO aggravated kidney injury after ischemia-reperfusion injury, and, in both conditions, the percentage of Th17 cells was increased.
Whereas Parkin (Montrer PARK2 Anticorps) has been reported to positively regulate the expression of OPA1 (Montrer MED12 Anticorps) through NEMO, herein we found that PARK2 (Montrer PARK2 Anticorps) overexpression did not modify the expression of OPA1 (Montrer MED12 Anticorps).
prevents colon inflammation by NF-kappaB (Montrer NFKB1 Anticorps)-independent functions
Thyrocyte-specific NEMO knock-out mice gradually develop hypothyroidism after birth, which leads to reduced body weight and shortened life span.
SENP1 (Montrer SENP1 Anticorps) deletion in adipocytes causes Type 1 diabetes mellitus via enhanced SUMOylation of NEMO, leading to increased NF-kappaB (Montrer NFKB1 Anticorps) activity, cytokine production and pancreatic inflammation.
Drosophila Kenny is a selective autophagy receptor that mediates the degradation of the IkappaB kinase (Montrer CHUK Anticorps) complex. Selective autophagic degradation of the IkappaB kinase (Montrer CHUK Anticorps) complex prevents constitutive activation of the immune deficiency pathway in response to commensal microbiota. We show that autophagy-deficient flies have a systemic innate immune response that promotes a hyperplasia phenotype in the midgut.
Porcine deltacoronavirus nsp5 (Montrer SPECC1 Anticorps), the 3C-like protease, inhibits interferon-beta (Montrer IFNB1 Anticorps) production through the cleavage of NEMO.
Nsp4 interfered with the NF-kappaB (Montrer NFKB1 Anticorps) signaling pathway through the cleavage of IKBKG at the E349-S350 site, leading to the downregulation of IFN-beta (Montrer IFNB1 Anticorps) production.
Foot-and-mouth disease virus 3C protease cleaves NEMO to impair innate immune signaling.
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.
I-kappa-B kinase subunit gamma
, IkB kinase gamma subunit
, NF-kappa-B essential modifier
, NF-kappa-B essential modulator
, NFkappaB essential modulator
, ikB kinase subunit gamma
, ikB kinase-associated protein 1
, incontinentia pigmenti
, inhibitor of nuclear factor kappa-B kinase subunit gamma
, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
, I-kappa-B kinase gamma
, NF-kappa B essential modulator
, inhibitor of kappaB kinase gamma
, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform 1
, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform 2
, NF-kappa-B essential modulator-like