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anti-Human SQSTM1 Anticorps:
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Human Monoclonal SQSTM1 Primary Antibody pour IF, ELISA - ABIN563860
Jung, Chung, Won Kim, Kim, Komatsu, Tanaka, Nguyen, Kang, Yoon, Kim, Jeong, Han, Lee, Kim, Shin, Lee: Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. dans Cell metabolism 2008
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Human Polyclonal SQSTM1 Primary Antibody pour ICC, IF - ABIN4343147
Pyo, Yoo, Ahn, Nah, Hong, Kam, Jung, Jung: Overexpression of Atg5 in mice activates autophagy and extends lifespan. dans Nature communications 2013
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Human Polyclonal SQSTM1 Primary Antibody pour IF, IHC (p) - ABIN388979
Seibenhener, Babu, Geetha, Wong, Krishna, Wooten: Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. dans Molecular and cellular biology 2004
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Human Polyclonal SQSTM1 Primary Antibody pour DB - ABIN1881831
Visconti, Langston, Alonso, Goodman, Selby, Fraser, Ralston: Mutations of SQSTM1 are associated with severity and clinical outcome in paget disease of bone. dans Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010
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Human Polyclonal SQSTM1 Primary Antibody pour DB - ABIN1881830
Ding, Ni, Li, Liao, Chen, Stolz, Dorn, Yin: Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. dans The Journal of biological chemistry 2010
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Human Polyclonal SQSTM1 Primary Antibody pour WB - ABIN1881829
Jain, Lamark, Sjøttem, Larsen, Awuh, Øvervatn, McMahon, Hayes, Johansen: p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. dans The Journal of biological chemistry 2010
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Human Monoclonal SQSTM1 Primary Antibody pour ELISA, WB - ABIN522359
Kirkin, Lamark, Sou, Bjørkøy, Nunn, Bruun, Shvets, McEwan, Clausen, Wild, Bilusic, Theurillat, Øvervatn, Ishii, Elazar, Komatsu, Dikic, Johansen: A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. dans Molecular cell 2009
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Human Polyclonal SQSTM1 Primary Antibody pour IF (p), IHC (p) - ABIN682153
Cui, Luo, Li, Li, Wang: Changes of intracellular Ca2+ in quercetin-induced autophagy progression. dans Acta biochimica et biophysica Sinica 2015
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Human Polyclonal SQSTM1 Primary Antibody pour ICC, IF - ABIN4343150
Gispert, Brehm, Weil, Seidel, Rüb, Kern, Walter, Roeper, Auburger: Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression. dans Human molecular genetics 2015
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Human Polyclonal SQSTM1 Primary Antibody pour ELISA, IHC - ABIN5588725
Park, Han, Choi, Kim, Park, Joe, Suh: Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy. dans PLoS ONE 2016
This study is the first to show a cytoplasmic function of claudin 1 (Montrer CLDN7 Anticorps) as an autophagy regulator and provides the evidence that claudin 1 (Montrer CLDN7 Anticorps)-mediated autophagy regulation is an integral part of the mechanism by which claudin 1 (Montrer CLDN7 Anticorps) regulates cancer progression.
The autophagy induced by 2-PCPA requires LC3 (Montrer MAP1LC3A Anticorps)-II processing machinery..2-PCPA treatment induces the change of global gene expression program, including a series of autophagy-related genes, such as SQSTM1/p62. Taken together, our data indicate that KDM1A/LSD1 (Montrer KDM1A Anticorps) inhibitors induce autophagy through affecting the expression of autophagy-related genes and in a BECN1 (Montrer BECN1 Anticorps)-independent manner
The results of this study reflect that Frontotemporal Dementia /SQSTM1 carriers show a right atrophy pattern in prefrontal-orbital-insular regions with relative preservation of the temporal lobes different from that observed in Sporadic Frontotemporal Dementia.
the L341V mutation limits the critical step of SQSTM1 recruitment to the phagophore
Endogenous p62 undergoes E2-dependent ubiquitylation during upregulation of Ubiquitin (Ub) homeostasis, a condition termed as Ub(+) stress, that is intrinsic to Ub overexpression, heat shock or prolonged proteasomal inhibition by bortezomib, a chemotherapeutic drug.
LC3 (Montrer MAP1LC3A Anticorps) and p62/SQSTM1 have roles in early-stage non-small cell lung cancer
LC3B and p62 have roles in autophagy in esophageal adenocarcinoma
ALS (Montrer IGFALS Anticorps)-FTLD associated mutations of SQSTM1 disrupt Keap1 (Montrer KEAP1 Anticorps) binding and disable Nrf2 (Montrer GABPA Anticorps) signaling.
analysis of soluble SQSTM1 complexes and soluble complexes formed between SQSTM1 oligomers and LC3 (Montrer MAP1LC3A Anticorps) using a combination of fluorescence microscopy-based biophysical approaches in living cells
ENC1 (Montrer ENC1 Anticorps) interacts with the phosphorylated p62 (Montrer GTF2H1 Anticorps) to impair autophagic degradation of mutant huntingtin (Montrer HTT Anticorps) protein aggregates.
The p62 (Montrer GTF2H1 Anticorps)-keap1 (Montrer KEAP1 Anticorps)-Nrf2 (Montrer NFE2L2 Anticorps) antioxidant pathway was primarily activated in the early stage of APAP hepatotoxicity.
this study proved that SYVN1 (Montrer SYVN1 Anticorps) enhances SERPINA1 (Montrer SERPINA1 Anticorps)(E342K)/ATZ degradation through SQSTM1-dependent autophagy and attenuates SERPINA1 (Montrer SERPINA1 Anticorps)(E342K)/ATZ cytotoxicity.
Data suggest that maternal nutrition modulates expression of autophagy proteins p62/Sqstm1 and Lc3 (Montrer MAP1LC3A Anticorps)-II/Map1lc3 (Montrer MAP1LC3B Anticorps) in liver and hypothalamus of offspring (newborn, suckling, and adult stages); for example, high-fat diet leading to maternal obesity up-regulates p62 (Montrer GTF2H1 Anticorps) and down-regulates Lc3 (Montrer MAP1LC3A Anticorps)-II in neonatal liver. (p62/Sqstm1 = sequestosome 1; Lc3 (Montrer MAP1LC3A Anticorps)-II/Map1lc3 (Montrer MAP1LC3B Anticorps) = microtubule-associated protein (Montrer SPAG5 Anticorps) 1-light chain 3)
TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy.
SQSTM1 dynamically associates with DNA damage foci (DDF) and regulates DNA repair.
Thyroid hormone (Montrer PTH Anticorps) promotes selective autophagy via induction of DAPK2 (Montrer DAPK2 Anticorps)-SQSTM1 cascade, which in turn protects hepatocytes from diethylnitrosamine-induced hepatotoxicity or carcinogenesis.
serine 351 phosphorylation of p62 (Montrer GTF2H1 Anticorps) did not enhance its binding to Keap1 (Montrer KEAP1 Anticorps) or stabilise the nuclear factor erythroid 2-related factor 2 (Nrf2 (Montrer NFE2L2 Anticorps)) transcription factor in this neuronal context. Nrf2 (Montrer NFE2L2 Anticorps) protein levels were markedly decreased despite transcriptional activation of the Nrf2 (Montrer NFE2L2 Anticorps) gene
Loss-of-function of SQSTM1 may cause phenotypic features characterized by locomotor deficits and motor neuron axonal defects that are associated with a misregulation of autophagic processes.
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
, sqstm1 protein
, EBI3-associated protein of 60 kDa
, EBI3-associated protein p60
, oxidative stress induced like
, phosphotyrosine independent ligand for the Lck SH2 domain p62
, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
, ubiquitin-binding protein p62
, oxidative stress induced
, PKC-zeta-interacting protein
, protein kinase C-zeta-interacting protein