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Cow (Bovine) Polyclonal HMGB1 Primary Antibody pour ELISA, FACS - ABIN250703
Barlan, Griffin, McGuire, Wiethoff: Adenovirus membrane penetration activates the NLRP3 inflammasome. dans Journal of virology 2010
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Human Monoclonal HMGB1 Primary Antibody pour CyTOF, FACS - ABIN4899428
Liou, Adler, Keogh, Li, Jensen, Walsh, Packer, Clark, Carveth, Chen, Rogers, Lane, Moore, Sturrock, Paine, Cox, Hoidal: Sputum biomarkers and the prediction of clinical outcomes in patients with cystic fibrosis. dans PLoS ONE 2012
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Human Polyclonal HMGB1 Primary Antibody pour IF (p), IHC (p) - ABIN671616
Zhao, Hu, Sun, Sun: The high mobility group box 1 protein of Sciaenops ocellatus is a secreted cytokine that stimulates macrophage activation. dans Developmental and comparative immunology 2011
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Human Polyclonal HMGB1 Primary Antibody pour ELISA, ICC - ABIN6269456
Wang, Sun, Li, Deng, Zeng, Tao, Wang, Guan, Zhao: Urinary MCP-1、HMGB1 increased in calcium nephrolithiasis patients and the influence of hypercalciuria on the production of the two cytokines. dans Urolithiasis 2016
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Human Monoclonal HMGB1 Primary Antibody pour IF, IHC (p) - ABIN561281
Krüger, Krick, Dhillon, Lerner, Ames, Bromberg, Lin, Walsh, Vella, Fischereder, Krämer, Colvin, Heeger, Murphy, Schröppel: Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation. dans Proceedings of the National Academy of Sciences of the United States of America 2009
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Human Polyclonal HMGB1 Primary Antibody pour IHC (p), WB - ABIN5518759
Bi, Zhu, Yan, Chen, Wang, Ma, Yang: Association of Upregulated HMGB1 and c-IAP2 Proteins With Hepatocellular Carcinoma Development and Progression. dans Hepatitis monthly 2015
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Human Polyclonal HMGB1 Primary Antibody pour IHC, WB - ABIN3023358
Yao, Zhao, Tang, Xiong, Zhao, Liu, Dong, Zou, Cai: Blockade of β-catenin signaling attenuates toluene diisocyanate-induced experimental asthma. dans Allergy 2017
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Human Polyclonal HMGB1 Primary Antibody pour IHC, WB - ABIN6673672
Chen, Yu, Yuan, Zhang, Fan, Yuan, Zhang, Yao: Enriched housing promotes post-stroke functional recovery through astrocytic HMGB1-IL-6-mediated angiogenesis. dans Cell death discovery 2017
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Human Monoclonal HMGB1 Primary Antibody pour IHC (p), ELISA - ABIN533532
Andersson, Erlandsson-Harris, Yang, Tracey: HMGB1 as a DNA-binding cytokine. dans Journal of leukocyte biology 2002
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Human Monoclonal HMGB1 Primary Antibody pour IF, IHC (p) - ABIN1326935
Kim, Ku, Bae: Persicarin is anti-inflammatory mediator against HMGB1-induced inflammatory responses in HUVECs and in CLP-induced sepsis mice. dans Journal of cellular physiology 2013
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HMGB1 release from several cancer cell lines increases with increased linear energy transfer
These results suggested that HMGB1M may partly promote inflammation and decrease DC maturation. Thus, the findings of the present study may provide insight into the complex role of HMGB1 in inflammatory diseases.
Studies indicate that the ubiquitous nuclear molecule high-mobility group box 1 protein (HMGB1) is a prototypical alarmin activating innate immunity [Review].
In response to HMGB1 stimulation, human aortic endothelial cells rapidly undergo ectodomain shedding of RAGE and TLR4, and thereby become insensitive to further HMGB1 stimulation.
Serum HMGB1 levels are correlated with endothelial dysfunction in patients with polycystic ovary syndrome.
The HMGB1 mRNA and protein expression levels in the colorectal cancer tissues were significantly higher than those in the adjacent normal mucosa. HMGB1 protein expression positively correlated with the lymph node metastasis.
found that HMGB1 complexes formation is catalyzed by the protein-cross-linking enzyme transglutaminase-2
Surface plasmon resonance studies showed that HMGB1 and its fragments (A-box and B-box) individually interact with the TLR4/MD-2 receptor with different binding and kinetic parameters. Our study also reveals that HMGB1 likely activates TLR4 signaling through inducing TLR4/MD-2 dimerization.
In summary, we have demonstrated that the C-terminal tail of HMGB1 negatively regulates the interaction with TLR2.
Left atrial platelet TLR-2 and TLR-4 expression and serum HMGB-1 levels were higher in persistent Atrial fibrillation(AF) patients compared to paroxysmal AF patients. In the patient group, left atrial expression of TLR-2, 4 and HMGB-1 were significantly higher than the peripheral expression levels.
HMGB1 gene rs2249825 and rs1045411 site SNPs are associated with sepsis.
Activated caspase-1 could be responsible for translocation and releases of HMGB1 in inflammatory cells. HMGB1 is a crucial mediator of uric acid-induced inflammation.
serum levels elevated in type 2 diabetes, further elevated in diabetic foot ulcer
miR-1284 enhances sensitivity of cervical cancer cells to cisplatin via targeting HMGB1; HMGB1 reversed the effects of miR-1284 on the progression and chemosensitivity of cervical cancer cells
Based on these findings, ischemia/reperfusion-induced MCPIP1 expression regulates the migration and apoptosis of human vascular endothelial cells via HMGB1 and CaSR, respectively.
Studied association of plasma levels of high mobility group box 1 (HMGB1) in critically ill patients.
The high-mobility group box (HMGB) proteins, particularly HMGB1, are self-derived innate immune activators that have multiple functions in the regulation of immunity and inflammation. Recent discoveries have illustrated the close link between HMGB1 and heart allograft rejection.
miR-193a plays a suppressive role in osteogenic differentiation of human bone marrow-derived stroma cell via targeting HMGB1.
Platelet HMGB1 mediated neutrophil-extracellular traps release is a primary regulator of deep vein thrombosis in mice.
Study findings suggested that TCTP promotes colorectal cancer metastasis through regulating the behaviors of HMGB1 and the downstream activation of the NF-kappaB signaling pathway.
dysfunctional/diminished S1PR1 contributes to the retention of malignant cells in the surrounding tissue, constituting a minimal residual disease reservoir that later may give rise to a relapse. In DLBCL, mutations of S1PR1 have not yet been reported, but lack of membrane expression of S1PR1 in DLBCL at early stages (Ann Arbor I+II) correlates to superior outcome
Inhibition of NLRP3 inflammasome reduced HMGB1 expression.
High HMGB1 expression is associated with pulmonary fibrosis.
The up-regulation of HMGB1 was thought to be modified by dual channels: in the transcriptional level, it was regulated by JNK1/JNK2-ATF2 axis; post-transcriptionally, it was regulated by the microRNA (miR)-200 family, especially miR-429. miR-429 liver conditional knockout mice (miR-429(Deltahep)), fed either a normal diet or an HFD, showed severe liver inflammation and dysfunction, accompanied by greater expression of ...
This study suggested that bone cancer related hyperalgesia is driven by PKC induced phosphorylation of HMGB1, which results in its translocation from the nucleus, and releasing from the cytosol of the dorsal horn, and the activation of spinal pro-inflammatory mediators.
HMGB1 specifically induces the release of Th2 cytokines through GRP75-mediated enhancement of ER-Mitochondrial Ca(2+) transfer and ROS increased.
Results show that oxaliplatin treatment enhanced HMGB1 expression associated with immunosuppression in the colon.
Results suggest that high-mobility group box 1 protein (HMGB1) plays an important role on the immunogenicity of the rTcdB-treated colon carcinoma CT26 cells.
HMGB1 released from hypoxia/reoxygenation (H/R)- induced islets works in an autocrine manner to up-regulate STAT or p38 and augment IL-1beta production via TLR2, and up-regulate NF-kappa B and augment TNF-alpha production via TLR4 in intra-islet, which are associated with H/R-induced islet injury and early graft failure.
down-regulation of nuclear HMGB1 reduces ischemia-induced HMGB1 release and protects against liver IRI, which is helpful for better understanding the role of HMGB1 in organ IRI.
a new pathway for the activation of Treg involving in tumor-derived HMGB1 and TSLP, and have important implications for incorporating HMGB1 inhibitors into cancer immunotherapy.
HMGB1 plays a novel role in modulating the YAP-dependent HIF1alpha pathway and shed light on the development of metabolism-targeting therapeutics for hepatocellular carcinoma chemoprevention
In lung tissues of LPS-endotoxemia, significantly increased levels of SNO-SIRT were found. Plasma nitrite and HMGB1 levels were significantly higher than those in the sham controls.
Established a murine model of myocardial ischemia-reperfusion injury; investigated and found remote ischemic postconditioning protects against IR injury thru RAGE-HMGB1 Pathway.
HMGB1 promotes HAdV-7 replication and signals through TLR-4, TLR-9, and RAGE receptors to activate NF-kappaB, stimulating the release of inflammatory mediators and contributing to adenoviral pathology.
Silencing of Hmgb1 by specific siRNA impeded the induction of 8-Br-cAMP on prolactin family 8, subfamily a, member 2 and Hmgb1 was a critical mediator of Kruppel-like factor 5 function in stromal differentiation.
In the lung, the expression of HMGB1 was greater in diet group and diet mechanical ventilation group than in control group and mechanical ventilation group.
these data suggest that HMGB1 may be a checkpoint nuclear factor of macrophage reprogramming
using Hmgb1(-/-) mice we identified the underlying mechanism as the transition of multiple quiescent stem cells from G0 to GAlert HMGB1
HMGB1 can act as an adjuvant in modulating the bovine immune system and thus lays a foundation for using HMGB1 as an adjuvant in various bovine vaccine preparations.
Single-nucleotide polymorphism in the 3'-untranslated region of the HMGB1 gene affects the binding of target bta-miR-223 and is involved in mastitis.
The mechanisms of interaction of the non-histone chromosomal protein HMGB1 and linker histone H1 with DNA have been studied using circular dichroism and absorption spectroscopy.
HMGB1 is able to induce considerable changes in DNA structure upon binding even when the amount of the protein directly associated with DNA is low
Interaction between non-histone chromatin protein HMGB1 and linker histone H1
HMGB-1 might play a role in the pathological thickening of subchondral bone plate/osteophyte formation.
Analysis of mechanical response generated by binding of DNA-bending protein HMGB1 to single tethered 48.5 kb lambda-DNA molecules finds that compaction of DNA increases with increasing HMGB1 concentration.
Thrombomoduln not only binds to HMGB1 but also aids the proteolytic cleavage of HMGB1 by thrombin.
SCARA5 is an HMGB1 recognition receptor that is negatively involved in HMGB1-mediated inflammation in pufferfish (Tetraodon nigroviridis) and zebrafish (Danio rerio) models.
HMGB1 is a critical factor for brain development, enabling survival and proliferation of neural progenitors that will form the forebrain structures.
Systemic HMGB-1 levels were significantly elevated in both trauma groups when compared to the sham group. Haemorrhagic shock severity and duration were positively correlated with HMGB-1 levels and compared to baseline values, concentrations remained significantly increased in severe hemorrhage when compared to moderate hemorrhage.
high levels of HMGB1 in the small intestine and its relation to high levels of HMGB1 in plasma of piglets infected with E. coli O55 that suffered from infection correlated with high levels of inflammatory cytokines and bacterial translocation; levels were higher than HMGB1 levels in piglets with mild clinical symptoms
HMGB-1 may participate in the inflammatory response and liver injury in the late stage of acute liver failure
High mobility group box-1 and nucleosomes might have use as biomarkers for horses with gastrointestinal disease.
Extracellular HMGB-1 is widespread only in synovial membrane from diseased joints in horses with osteoarthritis.
Osteochondral injury was associated with a significant increase in synovial HMGB-1 concentrations in horses with joint injuries, compared with results for clinically normal horses.
Airway pressure release ventilation reduces bronchoalveolar lavage fluid HMGB1 levels and lung water, preserving oxygenation and systemic blood pressure in experimental acute respiratory distress syndrome.
heparin binding protein that facilitates neurite outgrowth
, Sulfoglucuronyl carbohydrate binding protein
, high mobility group protein 1
, high mobility group protein B1
, high-mobility group (nonhistone chromosomal) protein 1
, high-mobility group box 1
, sulfoglucuronyl carbohydrate binding protein
, high mobility group box 1
, high mobility group 1 protein
, high mobility group protein HMG1
, non-histone protein HMG1
, high mobility group protein B1-like protein
, High mobility group protein B1
, high mobility group protein B1-like
, High mobility group protein 1
, heparin-binding protein p30
, high mobility group 1