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anti-Human HMGB1 Anticorps:
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Cow (Bovine) Polyclonal HMGB1 Primary Antibody pour ELISA, FACS - ABIN250703
Barlan, Griffin, McGuire, Wiethoff: Adenovirus membrane penetration activates the NLRP3 inflammasome. dans Journal of virology 2010
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Human Monoclonal HMGB1 Primary Antibody pour CyTOF, FACS - ABIN4899428
Liou, Adler, Keogh, Li, Jensen, Walsh, Packer, Clark, Carveth, Chen, Rogers, Lane, Moore, Sturrock, Paine, Cox, Hoidal: Sputum biomarkers and the prediction of clinical outcomes in patients with cystic fibrosis. dans PLoS ONE 2012
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Human Polyclonal HMGB1 Primary Antibody pour IF (p), IHC (p) - ABIN671616
Zhao, Hu, Sun, Sun: The high mobility group box 1 protein of Sciaenops ocellatus is a secreted cytokine that stimulates macrophage activation. dans Developmental and comparative immunology 2011
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Human Monoclonal HMGB1 Primary Antibody pour IF, IHC (p) - ABIN561281
Krüger, Krick, Dhillon, Lerner, Ames, Bromberg, Lin, Walsh, Vella, Fischereder, Krämer, Colvin, Heeger, Murphy, Schröppel: Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation. dans Proceedings of the National Academy of Sciences of the United States of America 2009
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Human Polyclonal HMGB1 Primary Antibody pour ELISA, ICC - ABIN6269456
Wang, Sun, Li, Deng, Zeng, Tao, Wang, Guan, Zhao: Urinary MCP-1、HMGB1 increased in calcium nephrolithiasis patients and the influence of hypercalciuria on the production of the two cytokines. dans Urolithiasis 2016
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Human Polyclonal HMGB1 Primary Antibody pour IHC (p), WB - ABIN5518759
Bi, Zhu, Yan, Chen, Wang, Ma, Yang: Association of Upregulated HMGB1 and c-IAP2 Proteins With Hepatocellular Carcinoma Development and Progression. dans Hepatitis monthly 2015
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Human Polyclonal HMGB1 Primary Antibody pour IHC, WB - ABIN6673672
Yao, Zhao, Tang, Xiong, Zhao, Liu, Dong, Zou, Cai: Blockade of β-catenin signaling attenuates toluene diisocyanate-induced experimental asthma. dans Allergy 2017
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Human Polyclonal HMGB1 Primary Antibody pour IHC, WB - ABIN3023358
Chen, Yu, Yuan, Zhang, Fan, Yuan, Zhang, Yao: Enriched housing promotes post-stroke functional recovery through astrocytic HMGB1-IL-6-mediated angiogenesis. dans Cell death discovery 2017
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Human Monoclonal HMGB1 Primary Antibody pour IHC (p), ELISA - ABIN533532
Andersson, Erlandsson-Harris, Yang, Tracey: HMGB1 as a DNA-binding cytokine. dans Journal of leukocyte biology 2002
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Human Monoclonal HMGB1 Primary Antibody pour IF, IHC (p) - ABIN1326935
Kim, Ku, Bae: Persicarin is anti-inflammatory mediator against HMGB1-induced inflammatory responses in HUVECs and in CLP-induced sepsis mice. dans Journal of cellular physiology 2013
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Microwave-mediated cold atmospheric plasma (CAP) increased high-mobility group box 1 protein (HMGB1) expression, thereby increasing HMGB-1 secretion. In addition, we observed that the calreticulin (CRT) protein was concentrated at the cellular membrane when plasma was treated, representing immunogenic cell death.
This review aims to encapsulate the relationship between HMGB1 and lung cancer, suggesting that HMGB1 plays a pivotal role in initiation, development, invasion, metastasis, and prognosis of lung cancer.
conclude that HMGB1 is a huntingtin N17/PY-NLS ROS-dependent interactor, and this protein bridging is essential for relaying ROS sensing by huntingtin to its nuclear entry during ROS stress.
OXA-increased HMGB1 expression was by inducing NF-kappaB-DNA-binding activity to in DLD-1 cells. Compared to a single agent, OXA combined with metformin administration resulted in cytotoxicity and cell growth inhibition synergistically, accompanied with reduced HMGB1 level.
By regulating CBP, Hsp27 maintained cell homeostasis and inhibited excessive inflammatory response.
abundance of HMGB1 mediates activation of HIF-1alpha in disc cells via Erk and JNK pathway and then, initiates VEGF secretion, thereby leading to disc angiogenesis and accelerating degenerative change of the perforated disc.
hypoxia exposure gave rise to HMGB1 expression in hepatoma cells of human and mouse in a HIF-1alpha-dependent manner and subsequently induced the infiltration and reprogramming of macrophages to augment the expression of Il-6.
The overexpression of miR-1284 inhibited the cell proliferation and migration, and altered the protein expression of epithelial-mesenchymal transition (EMT)-associated genes (E-cadherin, N-cadherin, Vimentin, and Snail), which was reversed by HMGB1 overexpression. In conclusion, miR-1284 can function as a new regulator to inhibit osteosarcoma cell proliferation and migration by targeting HMGB1.
Study reports for the first-time correlation of HMGB1 polymorphisms with urothelial cell carcinoma (UCC) risk. Carrying at least one T allele at rs1045411 is associated with a lower risk of UCC and a less invasive disease in women and nonsmokers.
Particulate matter 2.5 induces the expression of TGF-beta1, PDGF-AB, and PDGF-BB in vitro via HMGB1-RAGE signaling, suggesting that this pathway may contribute to the airway remodeling observed in patients with chronic obstructive pulmonary disease.
The HMGB1-TLR4 pathway was up-regulated in the neurons and astrocytes inside focal cortical dysplasia type II brain lesions.
HMGB1 blocker glycyrrhizin can inhibit activation of the TLR4/NF-kappaB signaling pathway and the secretion of inflammatory factors
Findings indicate that high mobility group box 1 (HMGB1) interacts with lipopolysaccharide (LPS) to mediate caspase-11-dependent pyroptosis in lethal sepsis.
Results show that plasma HMGB-1 concentrations were significantly increased in silicosis patients when compared with healthy controls. Elevated plasma HMGB-1 concentrations were positively associated with increased odds of silicosis.
HMGB1 promotes lipopolysaccharide-induced peritoneal mesothelial cells apoptosis, which is associated with JNK1-mediated upregulation of HMGB1 acetylation.
HMGB1 silencing promotes tumor cells viability and arrest of pro-apoptotic proteins via Stat3/NFkappaB signaling in HepG2 cells.
Hepatocyte and Kupffer cell-derived HMGB1 participates in the pathogenesis of liver fibrosis by signaling through RAGE in hepatic stellate cells to activate the pMEK1/2, pERK1/2 and pcJun pathway and increase Collagen type I deposition.
Together, HMGB1 and p53 provided a subtle balance between autophagy and apoptosis, thus determining the fate of PCB29-Polychlorinated biphenyl quinone-treated cells
Study data indicated that the overexpression of HMGB1 prior to treatment was correlated with poor clinical outcome in esophageal carcinoma and that knockdown HMGB1 expression in human esophageal cancer cell lines increased their radiosensitivity by allowing the induction of apoptosis and G0/G1 arrest after exposure to radiation.
HMGB1 levels (and high-sensitivity C-reactive protein) are significantly higher in Parkinson's disease patients compared to controls.
TGF-beta1 is a vital regulatory factor in denervated skeletal muscle in which HMGB1/ autophagy pathway mediates the atrophic effect of TGF-beta1
The data of this study showed that spinal HMGB1 was increased by ischemic stroke, and spinal HMGB1 colocalized with neurons but not microglia and astrocytes.
this study shows GSTP prevents sepsis-related HMGB1 Protein translocation and release
results indicate that HMGB1 may be an important contributor in the prevention and treatment of pneumonia of carbapenem-resistant-induced pneumonia
DNA methyltransferases 1 (DNMT1) inhibits high-mobility group box 1(HMGB1) expression in hypoxia-induced apoptosis in cardiac progenitor cells (CPCs).
HMGB1 triggers immune reversal through the mobilization, redistribution, and local immune differentiation of bone marrow cells, thereby compensating for impaired immunity and leading to sufficient bacterial eradication in late-phase sepsis
CD11b contributes to the development of sepsis, predominantly by facilitating nucleocytoplasmic translocation and active release of HMGB1.
dysfunctional/diminished S1PR1 contributes to the retention of malignant cells in the surrounding tissue, constituting a minimal residual disease reservoir that later may give rise to a relapse. In DLBCL, mutations of S1PR1 have not yet been reported, but lack of membrane expression of S1PR1 in DLBCL at early stages (Ann Arbor I+II) correlates to superior outcome
Inhibition of NLRP3 inflammasome reduced HMGB1 expression.
In summary, we have demonstrated that the C-terminal tail of HMGB1 negatively regulates the interaction with TLR2.
High HMGB1 expression is associated with pulmonary fibrosis.
The up-regulation of HMGB1 was thought to be modified by dual channels: in the transcriptional level, it was regulated by JNK1/JNK2-ATF2 axis; post-transcriptionally, it was regulated by the microRNA (miR)-200 family, especially miR-429. miR-429 liver conditional knockout mice (miR-429(Deltahep)), fed either a normal diet or an HFD, showed severe liver inflammation and dysfunction, accompanied by greater expression of ...
This study suggested that bone cancer related hyperalgesia is driven by PKC induced phosphorylation of HMGB1, which results in its translocation from the nucleus, and releasing from the cytosol of the dorsal horn, and the activation of spinal pro-inflammatory mediators.
HMGB1 specifically induces the release of Th2 cytokines through GRP75-mediated enhancement of ER-Mitochondrial Ca(2+) transfer and ROS increased.
Results show that oxaliplatin treatment enhanced HMGB1 expression associated with immunosuppression in the colon.
Results suggest that high-mobility group box 1 protein (HMGB1) plays an important role on the immunogenicity of the rTcdB-treated colon carcinoma CT26 cells.
HMGB1 released from hypoxia/reoxygenation (H/R)- induced islets works in an autocrine manner to up-regulate STAT or p38 and augment IL-1beta production via TLR2, and up-regulate NF-kappa B and augment TNF-alpha production via TLR4 in intra-islet, which are associated with H/R-induced islet injury and early graft failure.
HMGB1 can act as an adjuvant in modulating the bovine immune system and thus lays a foundation for using HMGB1 as an adjuvant in various bovine vaccine preparations.
Single-nucleotide polymorphism in the 3'-untranslated region of the HMGB1 gene affects the binding of target bta-miR-223 and is involved in mastitis.
The mechanisms of interaction of the non-histone chromosomal protein HMGB1 and linker histone H1 with DNA have been studied using circular dichroism and absorption spectroscopy.
HMGB1 is able to induce considerable changes in DNA structure upon binding even when the amount of the protein directly associated with DNA is low
Interaction between non-histone chromatin protein HMGB1 and linker histone H1
HMGB-1 might play a role in the pathological thickening of subchondral bone plate/osteophyte formation.
Analysis of mechanical response generated by binding of DNA-bending protein HMGB1 to single tethered 48.5 kb lambda-DNA molecules finds that compaction of DNA increases with increasing HMGB1 concentration.
Thrombomoduln not only binds to HMGB1 but also aids the proteolytic cleavage of HMGB1 by thrombin.
SCARA5 is an HMGB1 recognition receptor that is negatively involved in HMGB1-mediated inflammation in pufferfish (Tetraodon nigroviridis) and zebrafish (Danio rerio) models.
HMGB1 is a critical factor for brain development, enabling survival and proliferation of neural progenitors that will form the forebrain structures.
Systemic HMGB-1 levels were significantly elevated in both trauma groups when compared to the sham group. Haemorrhagic shock severity and duration were positively correlated with HMGB-1 levels and compared to baseline values, concentrations remained significantly increased in severe hemorrhage when compared to moderate hemorrhage.
high levels of HMGB1 in the small intestine and its relation to high levels of HMGB1 in plasma of piglets infected with E. coli O55 that suffered from infection correlated with high levels of inflammatory cytokines and bacterial translocation; levels were higher than HMGB1 levels in piglets with mild clinical symptoms
HMGB-1 may participate in the inflammatory response and liver injury in the late stage of acute liver failure
High mobility group box-1 and nucleosomes might have use as biomarkers for horses with gastrointestinal disease.
Extracellular HMGB-1 is widespread only in synovial membrane from diseased joints in horses with osteoarthritis.
Osteochondral injury was associated with a significant increase in synovial HMGB-1 concentrations in horses with joint injuries, compared with results for clinically normal horses.
Airway pressure release ventilation reduces bronchoalveolar lavage fluid HMGB1 levels and lung water, preserving oxygenation and systemic blood pressure in experimental acute respiratory distress syndrome.
heparin binding protein that facilitates neurite outgrowth
, Sulfoglucuronyl carbohydrate binding protein
, high mobility group protein 1
, high mobility group protein B1
, high-mobility group (nonhistone chromosomal) protein 1
, high-mobility group box 1
, sulfoglucuronyl carbohydrate binding protein
, high mobility group box 1
, high mobility group 1 protein
, high mobility group protein HMG1
, non-histone protein HMG1
, high mobility group protein B1-like protein
, High mobility group protein B1
, high mobility group protein B1-like
, High mobility group protein 1
, heparin-binding protein p30
, high mobility group 1