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anti-Human GRIA4 Anticorps:
anti-Rat (Rattus) GRIA4 Anticorps:
anti-Mouse (Murine) GRIA4 Anticorps:
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Human Polyclonal GRIA4 Primary Antibody pour IHC (p), IHC - ABIN314841
Earnshaw, Bressloff: Biophysical model of AMPA receptor trafficking and its regulation during long-term potentiation/long-term depression. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Human Polyclonal GRIA4 Primary Antibody pour IHC (p), WB - ABIN656865
Muntané, Horvath, Hof, Ely, Hopkins, Raghanti, Lewandowski, Wray, Sherwood: Analysis of synaptic gene expression in the neocortex of primates reveals evolutionary changes in glutamatergic neurotransmission. dans Cerebral cortex (New York, N.Y. : 1991) 2015
The authors suggest that pathogenic de novo variants in GRIA4 lead to intellectual disability with or without seizures, gait abnormalities, problems of social behavior, and other variable features.
Study shows that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluA4 is expressed on oligodendrocytes, myelin and on axons in humans.
A transient positive feedback mechanism between AMPAR and stargazin (Montrer CACNG2 Anticorps) has implications for information processing in the brain, because it should allow activity-dependent facilitation of excitatory synaptic transmission through a postsynaptic mechanism.
This study demonstrated that the GRIA4 protein was altered in auditory cortex patient with schizophreia.
Interaction with the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR4.
the levels were comparable for complexes containing GluR2 (Montrer GRIA2 Anticorps), GluR3 (Montrer GRIA3 Anticorps) and GluR4 as well as 5-HT1A (Montrer HTR1A Anticorps). Moreover, the levels of complexes containing muscarinic AChR M1, NR1 (Montrer GRIN1 Anticorps) and GluR1 (Montrer GRIA1 Anticorps) were significantly increased in male patients with AD.
Statistical analysis showed no association between migraine and the GRIA2 (Montrer GRIA2 Anticorps) and GRIA4 polymorphisms investigated.
The N-terminal domain modulates alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA (Montrer GRIA3 Anticorps)) receptor desensitization.
The data potentially suggest a lack of epistatic interaction between GRIA2 (Montrer GRIA2 Anticorps) and GRIA4 variants regarding clinical outcomes in patients with major depressive disorder.
Did not observed any significant association between GRIA4 polymorphisms and clinical improvement in patients with Major depressive disorder.
The central distribution of AMPARs is absent in GluA3 (Montrer GRIA3 Anticorps)-knockout mice, and gold particles are evenly distributed along the postsynaptic density. GluA4 gold labeling was homogenously distributed along both synapse types. Thus, GluA3 (Montrer GRIA3 Anticorps) and GluA4 subunits are distributed at auditory nerve synapses in a target-cell-dependent manner.
These data suggest that GluA4 enables efficient homeostatic upscaling and responsiveness to temporal activity patterns during the critical period of activity-dependent refinement of the circuitry.
this study shows that curcumin increased the GluR4 expression in bone marrow-derived dendritic cells activated with lipopolysaccharides, which likely contributed to the mechanism of inhibiting the Th17 cell differentiation
GluA4 subunits are required to produce an EPSC-triggerable postsynaptic action potentials after the presynaptic action potential, while Cav3.1 (Montrer CACNA1G Anticorps) expression is needed to establish the driver function of L5B-POm synapses at hyperpolarized membrane potentials
Data indicate that the AMPA (Montrer GRIA3 Anticorps) receptor subunits abundance is hippocampus, GluA2 (Montrer GRIA2 Anticorps) > GluA1 (Montrer GRIA1 Anticorps) > GluA3 (Montrer GRIA3 Anticorps) >> GluA4; cortex, GluA2 (Montrer GRIA2 Anticorps) > GluA3 (Montrer GRIA3 Anticorps) >/= GluA1 (Montrer GRIA1 Anticorps) >> GluA4; and cerebellum, GluA2 (Montrer GRIA2 Anticorps) > GluA3 (Montrer GRIA3 Anticorps) >/= GluA1 (Montrer GRIA1 Anticorps) > GluA4.
Here we identify a novel modifier - called "pecanex-like 2", or Pcnxl2 (Montrer PCNXL2 Anticorps) for short - that reduces the severity of spike-wave dischargesin the C3H substrain in which the Gria4 mutation originally arose
GluA4 expression is sufficient to alter the signaling mechanisms of synaptic plasticity and can fully explain the switch in the kinase dependency of long-term potentiation from PKA to Ca2+/calmodulin-dependent protein kinase II (Montrer CAMK2G Anticorps) during synapse maturation.
Postsynaptic density fractions from spinal cord dorsal horns showed an increase in GluA4 expression after morphine discontinuation.
The GluA4 subunit of the AMPA (Montrer GRIA3 Anticorps) receptor in the hippocampus (GluA4(HC-/-) mice) was ablated, thereby selectively reducing AMPA (Montrer GRIA3 Anticorps) receptor-mediated currents onto a subgroup of hippocampal interneurons expressing GluA4.
study found the majority of cerebellar GluA1 (Montrer GRIA1 Anticorps)/A4-type AMPARs are expressed in Bergmann glial (BG) cells; BG AMPARs are essential to optimize synaptic integration and cerebellar output function throughout life
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA\; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia.
glutamate receptor, ionotrophic, AMPA 4
, AMPA receptor GluR4/D
, glutamate receptor subunit GluR4
, glutamate receptor 4
, AMPA-selective glutamate receptor 4
, glutamate receptor, ionotropic, AMPA4 (alpha 4)
, glutamate receptor channel alpha 4
, glutamate receptor ionotropic, AMPA 4
, spike wave 1