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Human Polyclonal FGFR1 Primary Antibody pour FACS, IF - ABIN1882081
Jiao, Greendorfer, Zhang, Zinn, Diglio, Thompson: Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite. dans Archives of biochemistry and biophysics 2003
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Human Monoclonal FGFR1 Primary Antibody pour ELISA, WB - ABIN969138
Hu, Fang, Dunham, Prada, Stachowiak, Stachowiak: 90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling. dans The Journal of biological chemistry 2004
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Human Monoclonal FGFR1 Primary Antibody pour CyTOF, FACS - ABIN269474
Sasaki, Ishida, Toyota, Ota, Suzuki, Takaoka, Yasui, Yamamoto, Takagi, Maeda, Seito, Tsujisaki, Shinomura, Imai: Interferon-α/β and anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo. dans PLoS ONE 2011
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Human Monoclonal FGFR1 Primary Antibody pour CyTOF, FACS - ABIN268017
Zhao, Frist, Yeoh, Miller: Modification of alternative messenger RNA splicing of fibroblast growth factor receptors in human cardiac allografts during rejection. dans The Journal of clinical investigation 1994
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Human Monoclonal FGFR1 Primary Antibody pour ELISA, WB - ABIN966139
Magnusson, Ronca, DellEra, Carlstedt, Jakobsson, Partanen, Dimberg, Claesson-Welsh: Fibroblast growth factor receptor-1 expression is required for hematopoietic but not endothelial cell development. dans Arteriosclerosis, thrombosis, and vascular biology 2005
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Human Polyclonal FGFR1 Primary Antibody pour IHC (p), WB - ABIN3044410
Zhang, Zhang, Zhuang, Lu: Cytotoxicity of a novel fibroblast growth factor receptor targeted immunotoxin on a human ovarian teratocarcinoma cell line. dans Cancer biotherapy & radiopharmaceuticals 2006
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Human Monoclonal FGFR1 Primary Antibody pour CyTOF, FACS - ABIN250617
Robinson, MacMillan-Crow, Thompson, Overbeek: Expression of a truncated FGF receptor results in defective lens development in transgenic mice. dans Development (Cambridge, England) 1996
Human Polyclonal FGFR1 Primary Antibody pour IHC (p), IHC - ABIN250368
Torry, Mukherjea, Arroyo, Torry: Expression and function of placenta growth factor: implications for abnormal placentation. dans Journal of the Society for Gynecologic Investigation 2003
Human Monoclonal FGFR1 Primary Antibody pour CyTOF, FACS - ABIN250616
Wang, Kan, McKeehan, Jang, Feng, McKeehan: A homeo-interaction sequence in the ectodomain of the fibroblast growth factor receptor. dans The Journal of biological chemistry 1997
Cow (Bovine) Polyclonal FGFR1 Primary Antibody pour IHC (p), WB - ABIN4311478
Feng, Shao, Castro, Coleman, Nelson, Smith, Davies, Ittmann: Combination treatment of prostate cancer with FGF receptor and AKT kinase inhibitors. dans Oncotarget 2016
These results suggest that bFGF (Montrer FGF2 Anticorps) activation of neuronal FGFR1 generates filopodial processes in neurons that promote nerve-muscle interaction and facilitate NMJ establishment.
in FGFR1 signalling JNK1 (Montrer MAPK8 Anticorps) phosphorylation depends on ERK2 (Montrer MAPK1 Anticorps)
Mactosylceramide, an early product in GSL (Montrer CTSA Anticorps) biosynthesis, prevents inappropriate activation of insulin (Montrer INS Anticorps) and fibroblast growth factor receptors in Drosophila glial cells and hypertrophy.
identify two transcriptional regulators that function downstream of Heartless signaling in lymph gland progenitors, the ETS protein, Pointed, and the Friend-of-GATA protein, U-shaped, which are required for this Heartless-induced differentiation response
We show that salivary gland posterior migration requires the activities of genes that position the visceral mesoderm precursors, such as heartless, thickveins, and tinman (Montrer MSH2 Anticorps), but does not require a differentiated visceral mesoderm.
the signal provided by the CAMs acts via the Heartless fibroblast growth factor receptor (FGFR) as outgrowth is reduced to basal levels in the presence of an FGFR (Montrer FGFR2 Anticorps) inhibitor or if Heartless function is missing from the neurons.
FGFR1 and/or FGF3 (Montrer FGF3 Anticorps) gene amplification correlated with a lower pathologic complete response in patients with HER2 (Montrer ERBB2 Anticorps)(+) early breast cancer treated with neoadjuvant anti-HER2 (Montrer ERBB2 Anticorps) therapy.
Data demonstrated that FOXC1 (Montrer FOXC1 Anticorps) binds to an Fgfr1 upstream regulatory region and that FOXC1 (Montrer FOXC1 Anticorps) activates an Fgfr1 promoter element. Furthermore, elevated expression of Foxc1 (Montrer FOXC1 Anticorps) led to increased Fgfr1-IIIc transcript promoting invasion after TGFbeta1 (Montrer TGFB1 Anticorps)-induced EMT (Montrer ITK Anticorps).
These results suggest that FGFR1 gene amplification is a frequent alteration in squamous cell carcinoma of the lung and appears not to be a negative but rather a favorable prognostic marker for women and particularly for patients with advanced disease
These data suggest the ERalpha (Montrer ESR1 Anticorps) pathway remains active in estrogen-deprived ER(+)/FGFR1-amplified breast cancers. Therefore, these tumors are endocrine resistant and should be candidates for treatment with combinations of ER and FGFR (Montrer FGFR2 Anticorps) antagonists.
Amplification of gene FGFR1 is associated with lung adenocarcinoma.
Lysosomal sequestration - resulting in an organelle-specific and pH-dependent nintedanib fluorescence - was identified as an intrinsic resistance mechanism in FGFR (Montrer FGFR2 Anticorps)-driven lung cancer cells. Accordingly, combination of nintedanib with agents compromising lysosomal acidification (bafilomycin A1, chloroquine) exerted distinctly synergistic growth inhibitory effects
the close proximity between AcSDKP and FGFR1 was essential for the suppression of TGFbeta (Montrer TGFB1 Anticorps)/smad (Montrer SMAD1 Anticorps) signaling and EndMT associated with MAP4K4 (Montrer MAP4K4 Anticorps) phosphorylation (P-MAP4K4 (Montrer MAP4K4 Anticorps)) in endothelial cells.
Genetic testing identified a de novo, heterozygous mutation in fibroblast growth factor receptor 1 (FGFR1 p.L630P). L630 resides on the ATP binding cleft of the FGFR1 tyrosine kinase (Montrer TXK Anticorps) domain, and L630P is predicted to cause a complete loss of receptor function. Cell-based assays confirmed that L630P abolishes FGF8 (Montrer FGF8 Anticorps) signaling activity
This study reports a highly specific internalizing antibody fragment that can serve as a therapeutic targeting agent for efficient delivery of cytotoxic drugs into FGFR1-positive lung cancer cells.
anlotinib inhibits the activation of VEGFR2 (Montrer KDR Anticorps), PDGFRbeta and FGFR1 as well their common downstream ERK (Montrer EPHB2 Anticorps) signaling
Suboptimal FGFR (Montrer FGFR2 Anticorps) activation by a weak FGF1 (Montrer FGF1 Anticorps)-FGFR (Montrer FGFR2 Anticorps) dimer is sufficient to evoke a metabolic response, whereas full FGFR (Montrer FGFR2 Anticorps) activation by stable and sustained dimerization is required to elicit a mitogenic response.
FGFR1 is a driver oncogene (Montrer RAB1A Anticorps) in de novo, FGFR1-overexpressing acute myeloid leukemia (Montrer BCL11A Anticorps)
Visceral adipose tissue-derived factors stimulate cell transformation through FGFR-1.
the localization of FGF9 and its receptors at different embryonic and postnatal stages in mice testes, was examined.
CDC42 (Montrer CDC42 Anticorps) is involved in the trafficking of FGF receptors to the cell membrane to regulate epicardium formation.
MAPK (Montrer MAPK1 Anticorps) cascades participate in osteogenesis, but only the ERK (Montrer EPHB2 Anticorps) signaling pathway responds to FGFR1.
It is well accepted that myelin is a biologically active membrane in active communication with the axons. However, the axonal signals, the receptors on myelin, and the integration of intracellular signaling pathways emanating downstream from these receptors that drive the growth of the myelin sheath remain poorly understood in the CNS. This study brings up the intriguing possibility that FGF receptor (Montrer FGFR2 Anticorps) 2, in the oligodendr
data suggest that FGF2 (Montrer FGF2 Anticorps) levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor (Montrer NR3C1 Anticorps) expression, an effect that is likely receptor mediated, albeit not by FGFR1, FGFR2 (Montrer FGFR2 Anticorps), and FGFR3 (Montrer FGFR3 Anticorps).
clearly demonstrate the different specificity of FGF12 (Montrer FGF12 Anticorps)-FGFR1c2 and FGF22 (Montrer FGF22 Anticorps)-FGFR1c2 for well defined HS structures and suggest that it is now possible to chemoenzymatically synthesize precise HS polysaccharides that can selectively mediate growth factor signaling
activation of FGFR1 and FGFR2 (Montrer FGFR2 Anticorps) by uterine- and endometrial-derived FGF2 (Montrer FGF2 Anticorps) stimulates PI3K/AKT (Montrer AKT1 Anticorps) and mitogen-activated protein kinase (Montrer MAPK1 Anticorps) pathways for development of the porcine uterus and improvement of litter size
Alterations in the expression of VEGF-A (Montrer VEGFA Anticorps) and bFGF (Montrer FGF2 Anticorps) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
mRNA and protein expression of FGFR-1, FGFR-2 (Montrer FGFR2 Anticorps) in the porcine umbilical cord during pregnancy.
Here we demonstrate that of the nine FGFR1 mutations recently detected in our screen of over 200 HPE probands by next generation sequencing, only five distinct mutations in the kinase domain behave as dominant-negative mutations in zebrafish over-expression assays
we show that minimal amounts of Fgfr1a or Fgfr2 are required to initiate a regulatory cascade in pharyngeal endoderm reducing expression of fsta, thereby allowing correct BMP signaling to the maturing chondrocytes of the head cartilage.
Data indicate that fgf20a, fgf24, FGF receptor (Montrer FGFR2 Anticorps) fgfr1 are expressed in normal and regenerating barbel tissue.
Shroom3 (Montrer SHROOM3 Anticorps) is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish.
fgfr (Montrer FGFR2 Anticorps) expression is directly or indirectly regulated by FGF signaling during epiboly and at the end of somitogenesis.
we describe cloning and expression analysis of the zebrafish fibroblast growth factor receptor 1 ( fgfr1).
knock-down of Fgfr1, but not muscle segment homeobox B, affected the blastemal expression of msxc, suggesting this technique can be used to determine epistasis in genetic pathways affecting regeneration
Bmp and Fgf signaling are essential for liver specification in zebrafish.
The analysis of receptor-ligand interactions between D. rerio fgf8 (Montrer FGF8 Anticorps) and its receptors, fgfr1 and fgfr4 (Montrer FGFR4 Anticorps), using combined spectroscopy methods are reported.
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.
fibroblast growth factor receptor
, fibroblast growth factor receptor-1
, basic fibroblast growth factor receptor 1
, FGF receptor
, fibroblast growth factor receptor 1
, fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
, ibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
, basic fibroblast growth factor receptor 1-like
, FGFR1/PLAG1 fusion
, FMS-like tyrosine kinase 2
, fms-related tyrosine kinase 2
, heparin-binding growth factor receptor
, hydroxyaryl-protein kinase
, proto-oncogene c-Fgr
, FGF receptor-1
, cek1 protein
, tyrosine kinase receptor CEK1
, basic fibroblast growth factor receptor 1-A
, fibroblast growth factor receptor 1-A