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anti-Human DKK1 Anticorps:
anti-Rat (Rattus) DKK1 Anticorps:
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Human Monoclonal DKK1 Primary Antibody pour IHC (p), IP - ABIN524880
DAmelio, Roato, DAmico, Veneziano, Suman, Sassi, Bisignano, Ferracini, Gargiulo, Castoldi, Pescarmona, Isaia: Bone and bone marrow pro-osteoclastogenic cytokines are up-regulated in osteoporosis fragility fractures. dans Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2011
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Human Monoclonal DKK1 Primary Antibody pour ELISA, WB - ABIN966001
Bond, Kuhn, Binstadt, Quirk, Wu, Tews, Dev, Ericsson: The use of simulation in the development of individual cognitive expertise in emergency medicine. dans Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2008
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Dog (Canine) Polyclonal DKK1 Primary Antibody pour IF (p), IHC (p) - ABIN678158
Król, Mucha, Majchrzak, Homa, Bulkowska, Majewska, Gajewska, Pietrzak, Perszko, Romanowska, Paw?owski, Manuali, Hellmen, Motyl: Macrophages mediate a switch between canonical and non-canonical Wnt pathways in canine mammary tumors. dans PLoS ONE 2014
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Human Monoclonal DKK1 Primary Antibody pour ELISA, WB - ABIN969085
Yamamoto, Sakane, Yamamoto, Michiue, Kikuchi: Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling. dans Developmental cell 2008
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Human Polyclonal DKK1 Primary Antibody pour IHC (p), ELISA - ABIN250268
Fedi, Bafico, Nieto Soria, Burgess, Miki, Bottaro, Kraus, Aaronson: Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. dans The Journal of biological chemistry 1999
Human Monoclonal DKK1 Primary Antibody pour IHC (p), IP - ABIN524877
Brunetti, Faienza, Piacente, Ventura, Oranger, Carbone, Benedetto, Colaianni, Gigante, Mori, Gesualdo, Colucci, Cavallo, Grano: High dickkopf-1 levels in sera and leukocytes from children with 21-hydroxylase deficiency on chronic glucocorticoid treatment. dans American journal of physiology. Endocrinology and metabolism 2013
Human Polyclonal DKK1 Primary Antibody pour IHC (p), WB - ABIN388360
Yan, Wu, Chen, Diao, Lai, Huang, Chen, Yu, Gui, Tang, Cai: Developmental expression and function of DKKL1/Dkkl1 in humans and mice. dans Reproductive biology and endocrinology : RB&E 2012
Human Polyclonal DKK1 Primary Antibody pour IHC (p), ELISA - ABIN4369827
Krupnik, Sharp, Jiang, Robison, Chickering, Amaravadi, Brown, Guyot, Mays, Leiby, Chang, Duong, Goodearl, Gearing, Sokol, McCarthy: Functional and structural diversity of the human Dickkopf gene family. dans Gene 1999
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Human DKK1 Primary Antibody pour IHC (p) - ABIN643515
de Andrade, de Castro, Vicente, da Rosa, Nader, Pereira, Fröde: Evaluation of circulating levels of inflammatory and bone formation markers in axial spondyloarthritis. dans International immunopharmacology 2014
This study demonstrated that DKK-1 may be a predictor for prognosis in pancreatic ductal adenocarcinoma patients.
synovial fluid Dkk-1 levels are positively related to the severity of joint damage in knee osteoarthritis.
DKK1 exerts its pro-invasion function at least in part through the beta-catenin (Montrer CTNNB1 Anticorps)/ MMP-7 (Montrer MMP7 Anticorps) signaling pathway, suggesting DKK1 as a potential therapeutic target for human hilar cholangiocarcinoma (HCCA).
Sclerostin (Montrer SOST Anticorps) But Not Dickkopf-1 has roles in increasing prevalence of osteoporotic fracture and lower bone mineral density in postmenopausal Korean women
High serum levels of sclerostin (Montrer SOST Anticorps) and Dkk-1 are associated with acute ischaemic stroke
regulated by Dkk-1 secreted by Multiple Myeloma cells and is a potential mechanism contributing to the osteoblast dysfunction noted in Multiple Myeloma.
DKK1 c.121G>A (p.(A41T)) variant was identified in the family with Chiari malformation type 1. Screening of DKK1 in a cohort of 65 CMI sporadic patients identified another missense variant, the c.359G>T (p.(R120L)), in two unrelated patients.
LRP6 (Montrer LRP6 Anticorps) ectodomain becomes highly compact upon complexation with the Wnt (Montrer WNT2 Anticorps) antagonist Dkk1, suggesting a potential role for the ectodomain conformational change in the regulation of receptor oligomerization and signaling.
Our results suggest that measurement of DKK-1 combined with DKK-1 autoantibodies is a potentially valuable tool for the early detection of ESCC.
TET1 (Montrer TET1 Anticorps) potently inhibited canonical Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signaling by demethylating and upregulating two upstream antagonists of this pathway, SFRP2 (Montrer SFRP2 Anticorps) and DKK1, which was associated with inhibition of EMT (Montrer ITK Anticorps) and cancer cell metastasis.
The decreased expression of Dkk-1 in somatic cell nuclear transfer cotyledons that are prone to abnormal placentation suggests a role in cotyledon formation but the mechanism and regulatory control is yet to be revealed[DICKKOPF-1]
Palmatin effect on osteoarthritis is likely mediated via the Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) and Hedgehog (Montrer SHH Anticorps) signaling
DKK1 inhibits the WNT (Montrer WNT2 Anticorps) signaling pathway and improves pig oocyte maturation.
Association analysis showed that different genotypes of DKK1 were associated with loin muscle area.
activation of the FGF signaling pathway induces the formation of a dorsal axis with a complete head structure through the expression of chd (Montrer CHRD Anticorps) and subsequent maintenance of dkk1b expression levels.
Kremen1 (Montrer KREMEN1 Anticorps) modulates Wnt (Montrer WNT2 Anticorps) activity by restricting the range of secreted Dkk proteins during collective cell migration in the posterior lateral line primordium
Neuromast size is controlled by a balance between growth-promoting Wnt (Montrer WNT2 Anticorps) signaling activity in proliferation-competent cells and Wnt (Montrer WNT2 Anticorps)-inhibiting Dkk activity produced by differentiated sensory cells.
Dkk1b is abundantly produced by dense regions of androgen-regulated epidermal tubercles on the surfaces of adult male zebrafish pectoral fins
Data show that injury-dependent induction of Ascl1a (Montrer ASCL1A Anticorps) suppressed expression of the Wnt (Montrer WNT2 Anticorps) signaling inhibitor, Dkk, and induced expression of the Wnt (Montrer WNT2 Anticorps) ligand, Wnt4a.
Diabetic conditions increase the expression of DKK1.
DKK1 prevents lung metastasis of breast cancer cells but promotes breast-to-bone metastasis.
Membrane-bound DKK-1 is a novel Foxp3 (Montrer FOXP3 Anticorps) postive Treg cell derived mediator to maintain immunological tolerance in T-cell-mediated autoimmune colitis.
Dkk1 promotes hematopoietic regeneration via direct effects on hematopoietic stem cells, decreasing the levels of mitochondrial reactive oxygen species and suppressing senescence, and via indirect effects on bone marrow endothelial cells, inducing EGF (Montrer EGF Anticorps) secretion.
Recombinant Dkk1 suppresses beta-catenin (Montrer CTNNB1 Anticorps) target genes in myeloid-derived suppressor cells (MDSCs) from mice and humans and anti-Dkk1 loses its antitumor effects in mice lacking beta-catenin (Montrer CTNNB1 Anticorps) in myeloid cells or after depletion of MDSCs, demonstrating that Dkk1 directly targets MDSCs.
A negative feedback loop involving WNT6 (Montrer WNT6 Anticorps) and DKK1 attenuates canonical WNT6 (Montrer WNT6 Anticorps)-beta-catenin (Montrer CTNNB1 Anticorps) signaling, thereby allowing teratocarcinoma cells to differentiate.
Collectively, miR (Montrer MLXIP Anticorps)-9 promotes osteoblast differentiation of mesenchymal stem cells by suppressing DKK1 gene expression.
that Dkk1 negatively regulates BMP9 (Montrer GDF2 Anticorps)-induced osteogenic differentiation.
Disturbed oscillatory flow increases DKK1 expression. DKK1 knockdown attenuates OSS-induced monocyte adhesion and endothelial impairment. Genetic silencing of DKK1 limits atherogenesis in ApoE (Montrer APOE Anticorps)-/- mice.
Dickkopf1 receptor Kremen1 (Montrer KREMEN1 Anticorps) is a bona fide dependence receptor, triggering cell death unless bound to its ligand.
dkk1 preferentially induced the expression of POX2, suggesting that dkk1 works as a morphogen (Montrer SHH Anticorps) to determine the different lineages.
N1 is a novel signaling domain within the intact protein that is responsible for the potent effects of Dkk1 on the induction and patterning of the body axis and heart
target Wnts of Dkk activity are maternal Wnt5a (Montrer WNT5A Anticorps) and Wnt11, and that both Wnts are essential for canonical and non-canonical signaling
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
dickkopf 1 homolog
, dickkopf related protein-1
, dickkopf-1 like
, dickkopf-like protein 1
, dickkopf-related protein 1
, dickkopf homolog 1
, dickkopf 1
, dickkopf protein