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anti-Human PLA2G2A Anticorps:
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Human Polyclonal PLA2G2A Primary Antibody pour ELISA, WB - ABIN4345941
Villanueva, Little, Lambeau, Klegeris: Secreted phospholipase A(2) group IIA is a neurotoxin released by stimulated human glial cells. dans Molecular and cellular neurosciences 2012
the activity of human cPLA2alpha (Montrer PLA2G4A Anticorps) towards a multitude of glycerophospholipids species present in micelles or bilayers, was investigated.
Mutational analysis of functional sites showed that both peroxidase and PLA2 (Montrer YWHAZ Anticorps) active sites were necessary for mutant Prdx6 (Montrer PRDX6 Anticorps) function, and that Prdx6 (Montrer PRDX6 Anticorps) phosphorylation (at T177 residue) was essential for optimum PLA2 (Montrer YWHAZ Anticorps) activity.Mutant Prdx6 (Montrer PRDX6 Anticorps) at its Sumo1 (Montrer SUMO1 Anticorps) sites escapes and abates this adverse process by maintaining its integrity and gaining function
sPLA2-IIA activates Integrin alphaVbeta3 (Montrer ITGAV Anticorps) and Integrin alpha4beta1 in an allosteric manner. (Review)
Leptin (Montrer LEP Anticorps), at concentrations with minimal or no activating effects on astrocytoma cells, enhanced growth and migration promoted by low doses of sPLA2-IIA. sPLA2-IIA alone induced a transient phosphorylation pattern in the Src (Montrer SRC Anticorps)/ERK (Montrer EPHB2 Anticorps)/Akt (Montrer AKT1 Anticorps)/mTOR (Montrer FRAP1 Anticorps)/p70S6K (Montrer RPS6KB1 Anticorps)/rS6 pathway through EGFR (Montrer EGFR Anticorps) transactivation
Molecular dynamics simulations reveal structural insights into inhibitor binding modes and functionality in human PLA2G2A.
Hepatitis B virus can upregulate the expression of PLA2G2A, and serum levels of PLA2G2A are associated with the progression of hepatitis to liver cirrhosis and hepatocellular carcinoma.
Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2 (Montrer YWHAZ Anticorps), lipoxygenase and cyclooxygenase.
High expression of PLA2G2A was associated with poor therapeutic response and worse survival in patients with rectal cancer receiving neoadjuvant concurrent cheomoradiotherapy (CCRT).
Data show that phospholipase A2 group IIA, V and X have different target/function related activity.
Polyozellin might play an important role in the modulation of sPLA2-IIA expression and activity in response to the inflammatory diseases.
transgenic mice overexpressing sPLA2 -IIA keratinocytes showed enhanced activation of EGFR (Montrer EGFR Anticorps) and JNK1 (Montrer MAPK8 Anticorps)/2 that led to c-Jun (Montrer JUN Anticorps) activation.
PLA2 promotes pulmonary inflammation and systemic disease during Streptococcus pneumoniae infection.
secretory PLA2s have important functions as genetic modifiers of inflammation and colon cancer.
Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A2beta (iPLA2beta (Montrer PLA2G6 Anticorps)) and Group X Secreted Phospholipase A2 (Montrer YWHAZ Anticorps) (sPLA2).
Data show that the coordinated action of phospholipase A2 (Montrer YWHAZ Anticorps) IIA (sPLA2-IIA) and 12-lipoxygenase (12-LO (Montrer ALOX15 Anticorps)) promotes inflammatory arthritis.
Pla2g2a sequence varies between tumor resistant and sensitive mouse strains. Some of these variations in the promoter region affect Pla2g2a expression and nonsense-mediated RNA decay also contributes to reducing Pla2g2a mRNA in tumor-sensitive strains.
hydrolysis of the mitochondrial membrane by sPLA2-IIA yields inflammatory mediators (ie, lysophospholipids, fatty acids, and mtDNA) that promote leukocyte activation
Ionomycin causes susceptibility to phospholipase A2 while temperature-induced increases in membrane fluidity fail: possible involvement of actin fragmentation.
PLA2G2A production is induced by Pseudomonas aeruginosa.
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.
, group IIA phospholipase A2
, non-pancreatic secretory phospholipase A2
, phosphatidylcholine 2-acylhydrolase 2A
, phospholipase A2, membrane associated
, eted enzyme type IIA phospholipase A2
, platelet phospholipase A2
, enhancing factor
, modifier of Min1
, non-pancreatic secreted type II phospholipase A2
, secretory group II phospholipase A2
, typeII phospholipase A2