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Human Polyclonal SMAD1 Primary Antibody pour WB - ABIN1881815
Ye, Yu, Hu, Lu, Xie: Alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma. dans Journal of experimental & clinical cancer research : CR 2010
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Human Polyclonal SMAD1 Primary Antibody pour WB - ABIN3042628
Tao, Hu, Li, Liu, Wu, Li, Fu, Wei, Luo: Tranilast prevents the progression of chronic cyclosporine nephrotoxicity through regulation of transforming growth factor ?/Smad pathways. dans Transplantation proceedings 2011
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Human Polyclonal SMAD1 Primary Antibody pour WB - ABIN967044
Zhu, Kavsak, Abdollah, Wrana, Thomsen: A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. dans Nature 1999
Human Monoclonal SMAD1 Primary Antibody pour IF, IHC (p) - ABIN517610
Nakajima, Yanagihara, Nishii: Temporal and regional patterns of Smad activation in the rat hippocampus following global ischemia. dans Journal of the neurological sciences 2014
Human Polyclonal SMAD1 Primary Antibody pour WB - ABIN362414
Yamaguchi, Zhu, Yu, Sasaki, Umetsu, Kidachi, Ryoyama et al.: Serum-free mouse embryo cells generate a self-sustaining feedback loop for an astrocyte marker protein and respond to cytokines and bisphenol A in accordance with the subtle difference in their ... dans Cell biology international 2007
Data show that interplay of Smad1/5 and MAP kinase (Montrer MAPK1 Anticorps) signaling system (ERK (Montrer MAPK1 Anticorps) signalling) is essential for haemogenic endothelium-based haematopoietic stem cell emergence.
this study uncovers that smad1 and smad9 (Montrer SMAD9 Anticorps) act redundantly to each other downstream of smad5 (Montrer SMAD5 Anticorps) to mediate ventral specification and to regulate embryonic myelopoiesis.
that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 and Smad5 (Montrer SMAD5 Anticorps).
This report provides a genetic analysis of primary nociceptive neuron mechanisms that promote sensitization in response to injury. Drosophila melanogaster larvae whose primary nociceptive neurons were reduced in levels of specific components of the BMP signaling pathway, were injured and then tested for nocifensive responses to a normally subnoxious stimulus.
LTR sequence of the MDG4 (Montrer MOD(MDG4) Anticorps) retrotransposon contains the MAD protein (Montrer MXD1 Anticorps) binding site that affects the east-dependent repression
we identify key roles for the Zelda and Zerknullt transcription factors in establishing the resulting expression domain, and find widespread binding of insulator proteins to the Mad and Brinker-bound genomic regions. Analysis of embryos lacking the BEAF-32 insulator protein shows reduced transcription of a peak BMP target gene and a reduction in the number of amnioserosa cells, the fate specified by peak BMP signaling.
Mad linker phosphorylations control the intensity and range of the BMP-activity gradient in developing Drosophila tissues.
During development, synaptic pMad accumulation followed the arrival and clustering of ionotropic glutamate (Montrer GRIN2A Anticorps) receptors at neuromuscular junction synapses.
The actions of Brat at synapses are mediated through mothers against decapentaplegic (Mad), the signal transduction effector of the bone morphogenetic protein (BMP) signaling pathway.
Mad has distinct signal transduction roles in the BMP (Montrer TGFb Anticorps) and Wnt (Montrer WNT4 Anticorps) pathways depending on its phosphorylation state.
Yorkie (Montrer YAP1 Anticorps) and Mad physically bind each other, and 410 bp minimal enhancer of bantam that responds to Yorkie:Mad in vivo and in cultured cells, was identified.
Heterodimers of SAX and TKV play an important role in extending the BMP activity gradient by facilitating DPP diffusion and assisting GBB signaling through functional complexes with type II receptors.
importin-beta11 function interacts with the bone morphogenic protein (Montrer TGFb Anticorps) pathway to regulate a pool of phosphorylated mothers against decapentaplegic that must be present at the presynapse for its proper development and function
the expression of BMP15 (Montrer BMP15 Anticorps) in follicular fluid and Smad1 (Montrer GARS Anticorps) in granulosa cells was significantly decreased in the PCOS group compared with the control (P<0.05). The data suggested that the BMP15 (Montrer BMP15 Anticorps)/Smad1 (Montrer GARS Anticorps) signalling pathway may be involved in granulosa cell apoptosis
Mechanical stress affects the osteogenic differentiation of human ligamentum flavum cells via the BMP-Smad1 (Montrer GARS Anticorps) signaling pathway.
Urinary Smad1 (Montrer GARS Anticorps) was associated with the degree of mesangial expansion in early diabetic nephropathy.
Differential expression of TGF-beta (Montrer TGFB1 Anticorps) superfamily members and role of Smad1 (Montrer GARS Anticorps)/5/9-signalling in chondral versus endochondral chondrocyte differentiation.
Uev1A (Montrer UBE2V1 Anticorps) appears to be involved in the BMP signaling pathway in which it collaborates with a ubiquitin E3 ligase Smurf1 (Montrer SMURF1 Anticorps) to promote Smad1 (Montrer GARS Anticorps) degradation in a Ubc13 (Montrer UBE2N Anticorps)-independent manner.
Data show that miR (Montrer MLXIP Anticorps)-26b-5p suppresses Twist1 (Montrer TWIST1 Anticorps)-induced EMT (Montrer ITK Anticorps), invasion, and metastasis of HCC (Montrer FAM126A Anticorps) cells by targeting SMAD1 (Montrer GARS Anticorps).
Testosterone promoted tube formation of human umbilical endothelial cells, which was blocked by c-Src (Montrer SRC Anticorps) and ERK1/2 inhibitors or by the knockdown of Smad1 (Montrer GARS Anticorps).
Low doses of IL1B (Montrer IL1B Anticorps) activate the BMP/Smad signaling pathway to promote the osteogenesis of periodontal ligament stem cells, but higher doses of IL1B (Montrer IL1B Anticorps) inhibit BMP/Smad signaling through the activation of NF-kappaB (Montrer NFKB1 Anticorps) and MAPK (Montrer MAPK1 Anticorps) signaling, inhibiting osteogenesis.
Store operated calcium entry negatively regulates the Smad1 (Montrer GARS Anticorps) signaling pathway and inhibits Col (Montrer HDAC1 Anticorps) IV protein production in glomerular mesangial cells.
A significant association was found between the low expression of inhibitory protein SMAD-7 (Montrer SMAD7 Anticorps) and both zeta-chain-associated protein kinase (Montrer CDK7 Anticorps) 70-negative cells (p = 0.04) and lower apoptotic index (p = 0.004). No differences were observed in SMAD-2 (Montrer SMAD2 Anticorps)/3 expression. In conclusion, our results demonstrate a significant correlation between greater SMAD-1 (Montrer GARS Anticorps)/8 and lower SMAD-4 (Montrer SMAD4 Anticorps) expression in chronic lymphocytic leukemia cells
Results show that Smad1 plays an important role in the development of glomerular injury without affecting cell proliferation, in progressive glomerulonephritis.
These findings uncover crosstalk between the BMP-Smad1 and RANKL (Montrer TNFSF11 Anticorps)-NF-kappaB (Montrer NFKB1 Anticorps) pathways during osteoclastogenesis that underlies the action of active vitamin D on bone health.
CD137 (Montrer TNFRSF9 Anticorps) signaling is a new regulator of angiogenesis by modulating the Smad1/5-NFATc1 (Montrer NFATC1 Anticorps) pathway.
TGF-beta1 (Montrer TGFB1 Anticorps)-induced pSmad1 levels were elevated in Nedd4-deficient primary VSMCs isolated from Nedd4(fl/fl (Montrer FLT3LG Anticorps)) ;SM22alpha (Montrer TAGLN Anticorps)-Cre mice.
AA-enhanced cardiomyogenesis thus relies on the ability of AA to modulate the ratio of SMAD signaling among the TGFbeta (Montrer TGFB1 Anticorps)-superfamily receptor signaling pathways
Sphingosine 1 phosphate also up-regulated runt-related transcription factor 2 (Runx2 (Montrer RUNX2 Anticorps)) expression through S1PR2 (Montrer S1PR2 Anticorps)/RhoA (Montrer RHOA Anticorps)/ROCK/Smad1/5/8 signaling.
these results identify the PI3K-GSK3-SMAD1 axis as a central node integrating multiple signaling networks that govern bone formation and homeostasis.
We discovered that Smad1/5/4-Amhr2 (Montrer AMHR2 Anticorps)-cre KO females have malformed oviducts that subsequently develop oviductal diverticuli. In addition, uteri from Smad1/5/4-Amhr2 (Montrer AMHR2 Anticorps)-cre KO females exhibit multiple defects in stroma, epithelium, and smooth muscle layers and fail to assemble a closed uterine lumen upon embryo implantation, with defective uterine decidualization that led to pregnancy loss at early to mid-gestation.
these studies characterize an accessory TGF-beta (Montrer TGFB1 Anticorps)-stimulated BMP R-Smad signaling mechanism in interstitial cells of the developing lung.
these results identify a novel function of YAP (Montrer YAP1 Anticorps) in neocortical astrocytic differentiation and proliferation, and reveal a BMP2 (Montrer BMP2 Anticorps)-YAP (Montrer YAP1 Anticorps)-SMAD1 pathway underlying astrocytic differentiation in the developing mouse neocortex.
interactions between miR (Montrer MYLIP Anticorps)-26 and the Smad1 3'UTR (Montrer UTS2R Anticorps) modulate Smad1 function in the establishment of axial patterning.
a detailed computational model for TGF-beta (Montrer TGFB1 Anticorps) signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2 (Montrer SMAD2 Anticorps)/3 channels through a negative feedback loop dependent on Smad7 (Montrer SMAD7 Anticorps).
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
MAD homolog 1
, SMAD, mothers against DPP homolog 1
, mothers against decapentaplegic homolog 1
, mothers against decapentaplegic-like protein 1
, MAD (mothers against decapentaplegic, Drosophila) homolog 1
, SMA- and MAD-related protein 1
, SMAD 1
, SMAD family member 1
, mothers against DPP homolog 1
, mother against decapentaplegic
, mothers against decapentaplegi
, mothers against decapentaplegic
, mothers against dpp
, phosphorylated smad
, MAD, mothers against decapentaplegic homolog 1
, Mad-related protein 1
, TGF-beta signaling protein 1
, transforming growth factor-beta signaling protein 1
, transforming growth factor-beta-signaling protein 1
, Smad 1
, mad-related protein 1
, mothers-against-DPP-related 1
, MAD homolog1 (mothers against decapentaplegic, Drosophila)
, mothers against DPP
, BMP pathway effector
, BMP signal transducer Smad1
, Sma- and Mad-related protein 1