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anti-Human Prothrombin Anticorps:
anti-Mouse (Murine) Prothrombin Anticorps:
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Human Monoclonal Prothrombin Primary Antibody pour ELISA, WB - ABIN2192473
Yin, Wright, Wall, Grammas: Brain endothelial cells synthesize neurotoxic thrombin in Alzheimer's disease. dans The American journal of pathology 2010
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Human Polyclonal Prothrombin Primary Antibody pour IHC, ELISA - ABIN1583288
Fritze, Zhang, Li, Chai, Mulholland: Thrombin mediates vagal apoptosis and dysfunction in inflammatory bowel disease. dans Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2014
Human Polyclonal Prothrombin Primary Antibody pour CyTOF, FACS - ABIN4900737
Jesmin, Gando, Zaedi, Prodhan, Sawamura, Miyauchi, Hiroe, Yamaguchi: Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates renal fibrin deposition in a rat model of acute renal failure. dans Shock (Augusta, Ga.) 2009
Human Polyclonal Prothrombin Primary Antibody pour WB - ABIN515439
Huang, Wu, Tseng, Chen, Hsieh, Chen: Increased prothrombin, apolipoprotein A-IV, and haptoglobin in the cerebrospinal fluid of patients with Huntington's disease. dans PLoS ONE 2011
These findings suggest that contraction-dependent TGF-beta (Montrer TGFB1 Anticorps) activation could be a mechanism by which thrombin leads to the development of asthmatic airway remodeling.
Case Report: Paradoxical bleeding and thrombotic episodes of dysprothrombinaemia due to a homozygous Arg382His mutation I prothrombin.
PARP-1 (Montrer PARP1 Anticorps) activates prothrombin gene transcription and that the excessive prothrombin gene transcription induces des (Montrer DES Anticorps)-gamma-carboxy prothrombin (DCP (Montrer ACE Anticorps)) production in DCP (Montrer ACE Anticorps)-producing hepatocellular carcinoma cells.
the routine screening of patients with NAIS for F5 G1691A, F2 G20210A and MTHFR (Montrer MTHFR Anticorps) C677T gene mutations might not be justified, and additional prothrombotic mechanisms should be considered.
Although rare, the prothrombin Belgrade mutation represents strong thrombophilia with early onset of thrombosis in a large Serbian pedigree
There were no significant differences in factor V and factor II genotypes between infertile men and normal controls.
histone H4 has a rapid and drastic inhibitory effect on prothrombin activation by prothrombinase (Montrer F10 Anticorps) that is likely to dominate pathophysiology
prothrombotic mutations in factor V Leiden (Montrer F5 Anticorps) and prothrombin as well as older age are risk factors for venous thrombosis
p300 (Montrer EP300 Anticorps) inhibition attenuates both thrombin induced-CCL2 (Montrer CCL2 Anticorps) expression and histone H3 (Montrer HIST3H3 Anticorps) and H4 acetylation in HLFs, suggesting that p300 (Montrer EP300 Anticorps) is involved in thrombin-induced CCL2 (Montrer CCL2 Anticorps) expression via hyperacetylating histone H3 (Montrer HIST3H3 Anticorps) and H4.
p300 (Montrer EP300 Anticorps)-dependent histone H3 (Montrer HIST3H3 Anticorps) acetylation and C/EBPbeta (Montrer CEBPB Anticorps)-regulated IKKbeta (Montrer IKBKB Anticorps) expression contribute to thrombin-induced IL-8/CXCL8 (Montrer IL8 Anticorps) expression in human lung epithelial cells.
Platelet derived microparticles formed in sepsis are a potent inducer of thrombin generation via phosphatidylserine exposure, and activation of both the intrinsic and extrinsic pathway of coagulation.
These findings imply that a thrombin-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan (Montrer BGN Anticorps) plays a protective role during the progression of atherosclerosis in ApoE (Montrer APOE Anticorps)-deficient mice by inhibiting thrombin generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (Montrer GP1BA Anticorps)-binding and heparin-binding site of thrombin
thrombin/PAR-1 (Montrer MARK2 Anticorps) interaction regulated MCP-1 (Montrer CPT1B Anticorps), TF, MCSF (Montrer CSF1 Anticorps) and IL-6 (Montrer IL6 Anticorps) production.
Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (Montrer SERPINC1 Anticorps) nanoparticle therapeutics.
Thrombin-PAR1 (Montrer F2R Anticorps) signaling, via nitric oxide and EPCR (Montrer PROCR Anticorps), promotes hematopoietic stem cell (HSC (Montrer FUT1 Anticorps)) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 (Montrer CDC25C Anticorps) and Ras-associating domains of phospholipase C epsilon (Montrer PLCE1 Anticorps).
the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.
novel pyranosic sulfated (Montrer SULF1 Anticorps) arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated (Montrer SULF1 Anticorps) polysaccharides and glycosaminoglycans
Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.
the signaling pathways of MAPK (Montrer MAPK1 Anticorps), MSK1 (Montrer RPS6KA5 Anticorps), and NF-kappaB (Montrer NFKB1 Anticorps) play important roles in thrombin-induced iNOS (Montrer NOS2 Anticorps) expression in alveolar macrophages
High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.
Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (Montrer F2R Anticorps)) and thereby increasing the sensitivity of the myofilament to Ca(2 (Montrer CA2 Anticorps)+).
kinetic and structural analysis of interactions between thrombin and the Factor XIII (Montrer UGDH Anticorps) activation peptide
analysis of staphylocoagulase-mediated bovine prothrombin activation
thrombin and factor Xa (Montrer F10 Anticorps) diffusion along the heparin molecule explains the effects of extended heparin chain lengths
A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.
Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding
The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.
thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (Montrer UGDH Anticorps) and by receptor-mediated up-regulation of factor XIII (Montrer UGDH Anticorps) synthesis
In conclusion, thrombin activates pro-MMP-2 (Montrer MMP2 Anticorps) in the absence of elevated pro-MMP-2 (Montrer MMP2 Anticorps) expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2 (Montrer MMP2 Anticorps)
Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1 (Montrer F2R Anticorps), RhoA (Montrer RHOA Anticorps), and myocardin (Montrer MYOCD Anticorps).
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
prepro-coagulation factor II
, prothrombin B-chain
, serine protease
, coagulation factor 2