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Human Polyclonal HSP90B1 Primary Antibody pour IHC (f), ICC - ABIN966318
Green: The illusion of common ground and mythical pluralism. dans The International journal of psycho-analysis 2005
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Human Polyclonal HSP90B1 Primary Antibody pour ICC, IF - ABIN4315457
Ito, Mimae, Yamamoto, Hagiyama, Nakanishi, Ito, Hosokawa, Okada, Murakami, Kondo: Novel application for pseudopodia proteomics using excimer laser ablation and two-dimensional difference gel electrophoresis. dans Laboratory investigation; a journal of technical methods and pathology 2012
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Human Polyclonal HSP90B1 Primary Antibody pour ICC, IHC (fro) - ABIN3044299
Wang, Wang, Huang, Yang, Zhao, Wei, Zhao: Erratum to: Ibutilide protects against cardiomyocytes injury via inhibiting endoplasmic reticulum and mitochondrial stress pathways. dans Heart and vessels 2016
GRP94 is tightly associated with the cell surface of parietal cells from rabbit gastric mucosa, where it exhibits high-affinity binding for the adenosine receptor agonist NECA and specific inhibitor radicicol.
Study demonstrated that the lack of gp96 in both the human monocytic cell line MM6 and in macrophages from LysMcre-gp96 floxed mice neither leads to a complete loss of TLR 2 expression nor to a complete loss of TLR-induced signaling, but is associated with an impaired phosphorylation of ERK (Montrer EPHB2 Anticorps) and p38 (Montrer CRK Anticorps). These results reveal for the first time a crucial role for gp96 in the regulation of ERK (Montrer EPHB2 Anticorps) and p38 (Montrer CRK Anticorps) kinases.
GRP94 Knock-out mice exhibits impaired glucose tolerance. GRP94 is an essential regulator of pancreatic beta-cell development, mass, and function.
These data demonstrate the essential role of the gp96-TLR interaction in priming T cell immunity and provide further molecular basis for the coupling of gp96-mediated innate with adaptive immunity.
Heat-shock protein gp96 enhances T cell responses and protective potential to BCG (Montrer SLC11A1 Anticorps) vaccine.
binding of PCSK9 (Montrer PCSK9 Anticorps) to GRP94 protects LDLR (Montrer LDLR Anticorps) from degradation likely by preventing early binding of PCSK9 (Montrer PCSK9 Anticorps) to LDLR (Montrer LDLR Anticorps)
These data indicate that macrophage gp96 is essential for protective immunity during Gram-negative pneumonia
gp96 participates in the generation of natural Treg cells, which might be involved in the control of liver regeneration in the periphery
These studies imply GRP78 (Montrer HSPA5 Anticorps), but not GRP94, is required for mammary gland development.
GRP94 deficiency in the liver led to injury, LPC (Montrer PCSK7 Anticorps) expansion, increased proliferation, activation of oncogenic signaling, progressive repopulation of GRP94-positive hepatocytes and HCC (Montrer FAM126A Anticorps) development in aged mice.
GP96 serves as an essential chaperone for the cell-surface protein (Montrer CD28 Anticorps) glycoprotein A repetitions predominant (GARP (Montrer LRRC32 Anticorps)), which is a docking receptor for latent membrane-associated TGF-beta (Montrer TGFB1 Anticorps) (mLTGF-beta).
Glucose-regulated protein GRP94 contributes to the development of an aggressive phenotype in breast cancer cells.
Concomitant high expression of ERalpha36, GRP78 (Montrer HSPA5 Anticorps) and GRP94 is associated with aggressive papillary thyroid cancer behavior and may be used as a predictor for extrathyroid extension, lymph node metastasis, and distant metastasis.
Overexpressed miR (Montrer MLXIP Anticorps)-150 attenuates hypoxia-induced human cardiomyocyte cell apoptosis by targeting GRP94.
Regulation of CLC-1 (Montrer CLCN1 Anticorps) chloride channel (Montrer CLCA1 Anticorps) biosynthesis by FKBP8 (Montrer FKBP8 Anticorps) and Hsp90beta (Montrer HSP90AB1 Anticorps) as a molecular model for myotonia congenita has been described.
HSP-gp96 promotes T cell response, enhances DC antigen presentation and induces cytokine secretion in human gastric cancer cell lines.
our results besides adding further evidence in support of Grp94 as the shared tumor antigen in tumors of the GI tract, prove that it can be measured in plasma as valuable diagnostic marker of disease in the form of complexes with IgG that also exert immune-modulating activities on circulating immune cells.
High GRP94 expression is associated with endometrioid adenocarcinoma.
Immuno-stimulating peptide derived from HMGB1 (Montrer HMGB1 Anticorps) is more effective than the N-terminal domain of Gp96 as an endogenous adjuvant for improvement of protein vaccines.
structural maturation of the client protein substrate, rather than ATP binding or hydrolysis, serves as the primary signal for dissociation of GRP94-client protein complexes [GRP94]
These results identify a compact, intertwined quaternary conformation of native GRP94
This study showed that ubiquitinated ALK5 (Montrer TGFBR1 Anticorps) and phosphorylated heat shock protein 27 specifically accumulate in the cytoskeleton fraction, and ALK1 (Montrer ACVRL1 Anticorps) and ALK5 (Montrer TGFBR1 Anticorps) interact with heat shock protein 90(HSP90 (Montrer HSP90 Anticorps)).
In Xenopus, gp96 can prime CD8(+) T-cell effectors that are not MHC restricted.
This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15.
tumor rejection antigen (gp96) 1
, 94 kD glucose-regulated protein
, endoplasmin-like protein
, 94 kDa glucose-regulated protein
, endoplasmic reticulum resident protein 99
, heat shock protein 90 kDa beta member 1
, polymorphic tumor rejection antigen 1
, transforming growth factor alpha regulated gene 2
, tumor rejection antigen gp96
, heat shock protein 90kDa beta (grp94), member 1
, heat shock protein 90kDa beta (Grp94), member 1
, endothelial cell (HBMEC) glycoprotein
, stress-inducible tumor rejection antigen gp96
, tumor rejection antigen 1
, 98 kDa protein kinase
, PPK 98
, gp96 homolog
, heat shock protein 90kDa beta, member 1
, heat shock protein gp96
, HSP 108
, heat shock 108 kDa protein
, heat shock protein 108
, transferrin-binding protein