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Cycle Cellulaire

Any growing organism – regardless of it being single- or multi-cellular – rests upon the reiteration the growth and division of existing cells under favorable conditions. During each round of this process, the cell cycles through an ordered series of events in which its genetic information is duplicated and then splits up into two cells. These events are tightly regulated and certain checkpoints must be passed in order for the cell cycle to be completed. The loss of control of these processes is a hallmark of cancer.

The cell cycle is split up into four major phases based on the events unfolding in the cell. During the first gap phase (G1) the proteins are produced that are essential for DNA replication. The genetic information is then being replicated during the synthesis (S) phase. In the second gap phase (G2) all the components that are necessary for the separation of the duplicated DNA during the subsequent mitosis (M phase). Cells that are not actively dividing are considered to be in a quiescent state in the resting phase G0. Two checkpoints between G1/S and G2/M phase must be passed in order for the cell cycle to progress.

Once replication, DNA replication must be finished. Therefore, the major checkpoint in the cell cycle is the restriction (R) point between G1 and S phases, prior to DNA duplication, at which the cycle progresses depending on mitogenic or inhibitory factors such as DNA damage and signals from various signaling pathways. A second checkpoint is at the intersection between G2 and M phases. Progression from one phase to another is controlled by cyclin dependent kinases (CDK) and their activators, cyclins. Latter proteins are unstable and their cellular concentration cycles throughout the cell cycle. Accordingly, specific cyclin-CDK complexes are characteristic for the different cell cycle phases. In addition, their activity is further modulated by CDK inhibitors. Collectively, these factors maintain balance on a cellular level and beyond.

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Cyclin Dependent Kinase

CDK1 (Cyclin-Dependent Kinase 1):

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity...   More...

CDK2 (Cyclin-Dependent Kinase 2):

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and...   More...

CDK4 (Cyclin-Dependent Kinase 4):

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S....

CDK6 (Cyclin-Dependent Kinase 6):

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene...
Antigène dans cette catégorie:
CDK2AP2 (Cyclin-Dependent Kinase 2 Associated Protein 2): CDK2AP2 anticorps CDK2AP2 ELISA Kits CDK2AP2 Proteins
CDK3 (Cyclin-Dependent Kinase 3): CDK3 anticorps CDK3 ELISA Kits CDK3 Proteins
CDKL3 (Cyclin-Dependent Kinase-Like 3): CDKL3 anticorps CDKL3 ELISA Kits CDKL3 Proteins
CDK5 (Cyclin-Dependent Kinase 5): CDK5 anticorps CDK5 ELISA Kits CDK5 Proteins
CDK7 (Cyclin-Dependent Kinase 7): CDK7 anticorps CDK7 ELISA Kits CDK7 Proteins
CDK8 (Cyclin-Dependent Kinase 8): CDK8 anticorps CDK8 ELISA Kits CDK8 Proteins
CDK9 (Cyclin-Dependent Kinase 9): CDK9 anticorps CDK9 ELISA Kits CDK9 Proteins

Cyclins

CCNB1 - Cyclin B1

The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of...   More...

CCNE1 - Cyclin E1

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex...   More...

CCNB2 - Cyclin B2

Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are...

CCNE2 - Cyclin E2

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in...
Antigène dans cette catégorie:
CCNA1 - Cyclin A1: CCNA1 anticorps CCNA1 ELISA Kits CCNA1 Proteins
CCNA2 - Cyclin A: CCNA2 anticorps CCNA2 ELISA Kits CCNA2 Proteins
CCNB3 - Cyclin B3: CCNB3 anticorps CCNB3 ELISA Kits CCNB3 Proteins
CCNC - Cyclin C: CCNC anticorps CCNC ELISA Kits CCNC Proteins
CCND1 - Cyclin D1: CCND1 anticorps CCND1 ELISA Kits CCND1 Proteins
CCND2 - Cyclin D2: CCND2 anticorps CCND2 ELISA Kits CCND2 Proteins
CCND3 - Cyclin D3: CCND3 anticorps CCND3 ELISA Kits CCND3 Proteins
CCNH - Cyclin H: CCNH anticorps CCNH ELISA Kits CCNH Proteins
CCNI - Cyclin I: CCNI anticorps CCNI ELISA Kits CCNI Proteins

G1-S Checkpoint

CDC25A (Cell Division Cycle 25 Homolog A (S. Pombe)):

CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although...   More...

CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4)):

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This...

CDKN1A (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1)):

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4...
Antigène dans cette catégorie:
FOXO1 (Forkhead Box O1): FOXO1 anticorps FOXO1 ELISA Kits FOXO1 Proteins
FOXO3 (Forkhead Box O3): FOXO3 anticorps FOXO3 ELISA Kits FOXO3 Proteins
FOXO4 (Forkhead Box O4): FOXO4 anticorps FOXO4 ELISA Kits FOXO4 Proteins
SMAD2 (SMAD, Mothers Against DPP Homolog 2): SMAD2 anticorps SMAD2 ELISA Kits SMAD2 Proteins
SMAD3 (SMAD, Mothers Against DPP Homolog 3): SMAD3 anticorps SMAD3 ELISA Kits SMAD3 Proteins
SMAD4 (SMAD Family Member 4): SMAD4 anticorps SMAD4 ELISA Kits SMAD4 Proteins
BMI1 (BMI1 Polycomb Ring Finger Oncogene): BMI1 anticorps BMI1 ELISA Kits BMI1 Proteins
MNAT1 (Menage A Trois Homolog 1, Cyclin H Assembly Factor (Xenopus Laevis)): MNAT1 anticorps MNAT1 ELISA Kits MNAT1 Proteins
CDC25B (Cell Division Cycle 25 Homolog B (S. Pombe)): CDC25B anticorps CDC25B ELISA Kits CDC25B Proteins
CDC25C (Cell Division Cycle 25 Homolog C (S. Pombe)): CDC25C anticorps CDC25C ELISA Kits CDC25C Proteins
RASGRF1 (Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1): RASGRF1 anticorps RASGRF1 ELISA Kits RASGRF1 Proteins
CDKN2C (Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4)): CDKN2C anticorps CDKN2C ELISA Kits CDKN2C Proteins
CDKN2D (Cyclin-Dependent Kinase Inhibitor 2D (p19, Inhibits CDK4)): CDKN2D anticorps CDKN2D ELISA Kits CDKN2D Proteins
CDKN1A (Cyclin-Dependent Kinase Inhibitor 1A): CDKN1A anticorps CDKN1A ELISA Kits CDKN1A Proteins
CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1)): CDKN1B anticorps CDKN1B ELISA Kits CDKN1B Proteins
CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2)): CDKN1C anticorps CDKN1C ELISA Kits CDKN1C Proteins
MYC - C-MYC: MYC anticorps MYC ELISA Kits MYC Proteins
MYC - V-Myc Avian Myelocytomatosis Viral Oncogene Homolog: MYC anticorps MYC ELISA Kits  

E2F/RB

RB1 - Retinoblastoma 1

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder...   More...

E2F1 (E2F Transcription Factor 1):

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a...   More...
Antigène dans cette catégorie:
E2F2 (E2F Transcription Factor 2): E2F2 anticorps E2F2 ELISA Kits E2F2 Proteins
E2F4 (E2F Transcription Factor 4, P107/p130-Binding): E2F4 anticorps E2F4 ELISA Kits E2F4 Proteins
TFDP1 - DP1: TFDP1 anticorps TFDP1 ELISA Kits TFDP1 Proteins
TFDP2 - DP2: TFDP2 anticorps TFDP2 ELISA Kits TFDP2 Proteins
RBL1 - p107: RBL1 anticorps RBL1 ELISA Kits RBL1 Proteins
RBL2 - p130: RBL2 anticorps RBL2 ELISA Kits RBL2 Proteins

G2-M Checkpoint

CHEK1 (Checkpoint Kinase 1):

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response...

CHEK2 - Checkpoint Kinase 2

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The...
Antigène dans cette catégorie:
MNAT1 (Menage A Trois Homolog 1, Cyclin H Assembly Factor (Xenopus Laevis)): MNAT1 anticorps MNAT1 ELISA Kits MNAT1 Proteins
CDC25A (Cell Division Cycle 25 Homolog A (S. Pombe)): CDC25A anticorps CDC25A ELISA Kits CDC25A Proteins
CDC25B (Cell Division Cycle 25 Homolog B (S. Pombe)): CDC25B anticorps CDC25B ELISA Kits CDC25B Proteins
CDC25C (Cell Division Cycle 25 Homolog C (S. Pombe)): CDC25C anticorps CDC25C ELISA Kits CDC25C Proteins
RASGRF1 (Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1): RASGRF1 anticorps RASGRF1 ELISA Kits RASGRF1 Proteins
WEE1 (WEE1 Homolog (S. Pombe)): WEE1 anticorps WEE1 ELISA Kits WEE1 Proteins
MYT1 (Myelin Transcription Factor 1): MYT1 anticorps MYT1 ELISA Kits MYT1 Proteins
PLK1 (Polo-Like Kinase 1): PLK1 anticorps PLK1 ELISA Kits  
PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D): PPM1D anticorps PPM1D ELISA Kits PPM1D Proteins
GADD45A (Growth Arrest and DNA-Damage-Inducible, alpha): GADD45A anticorps GADD45A ELISA Kits GADD45A Proteins
GADD45B (Growth Arrest and DNA-Damage-Inducible, beta): GADD45B anticorps GADD45B ELISA Kits GADD45B Proteins
GADD45G (Growth Arrest and DNA-Damage-Inducible, gamma): GADD45G anticorps GADD45G ELISA Kits GADD45G Proteins
MDM4 - MDM4-binding Protein: MDM4 anticorps MDM4 ELISA Kits MDM4 Proteins
BRCA1 (Breast Cancer 1): BRCA1 anticorps BRCA1 ELISA Kits BRCA1 Proteins
RBBP8 - Retinoblastoma Binding Protein 8: RBBP8 anticorps RBBP8 ELISA Kits RBBP8 Proteins
HIPK2 (Homeodomain Interacting Protein Kinase 2): HIPK2 anticorps HIPK2 ELISA Kits HIPK2 Proteins
TOP2A - Topoisomerase II alpha: TOP2A anticorps TOP2A ELISA Kits TOP2A Proteins
TERF1 - TRF1: TERF1 anticorps TERF1 ELISA Kits TERF1 Proteins
TERF2 - TRF2: TERF2 anticorps TERF2 ELISA Kits TERF2 Proteins
TINF2 (TIN2): TINF2 anticorps TINF2 ELISA Kits TINF2 Proteins
TPP1 (Tripeptidyl Peptidase I): TPP1 anticorps TPP1 ELISA Kits TPP1 Proteins
POT1 (Protection of Telomeres 1): POT1 anticorps    
POT1 (Protection of Telomeres 1 Homolog (S. Pombe)): POT1 anticorps POT1 ELISA Kits POT1 Proteins
TERF2IP - RAP1: TERF2IP anticorps TERF2IP ELISA Kits TERF2IP Proteins
AURKA - Aurora A: AURKA anticorps AURKA ELISA Kits AURKA Proteins
CDKN1A (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1)): CDKN1A anticorps CDKN1A ELISA Kits CDKN1A Proteins
CDKN1A (Cyclin-Dependent Kinase Inhibitor 1A): CDKN1A anticorps CDKN1A ELISA Kits CDKN1A Proteins
MDM2 (Mdm2 P53 Binding Protein Homolog (Mouse)):   MDM2 ELISA Kits  
MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse)): MDM2 anticorps MDM2 ELISA Kits MDM2 Proteins

M Phase

INCENP (Inner Centromere Protein Antigens 135/155kDa):

In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A\; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses...   More...
Antigène dans cette catégorie:
AURKB - Aurora Kinase B: AURKB anticorps AURKB ELISA Kits AURKB Proteins
AURKC - Aurora Kinase C: AURKC anticorps AURKC ELISA Kits AURKC Proteins
CDCA8 (Cell Division Cycle Associated 8): CDCA8 anticorps CDCA8 ELISA Kits CDCA8 Proteins
BIRC5 (Baculoviral IAP Repeat-Containing 5): BIRC5 anticorps BIRC5 ELISA Kits BIRC5 Proteins
EPR1 (Early-Phytochrome-Responsive1): EPR1 anticorps    

CSN Complex

GPS1 (G Protein Pathway Suppressor 1):

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant...

COPS6 (COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis)):

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an...
Antigène dans cette catégorie:
COPS2 - COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis): COPS2 anticorps COPS2 ELISA Kits COPS2 Proteins
COPS3 (COP9 Constitutive Photomorphogenic Homolog Subunit 3 (Arabidopsis)): COPS3 anticorps COPS3 ELISA Kits COPS3 Proteins
COPS4 (COP9 Constitutive Photomorphogenic Homolog Subunit 4 (Arabidopsis)): COPS4 anticorps COPS4 ELISA Kits COPS4 Proteins
COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis)): COPS5 anticorps COPS5 ELISA Kits COPS5 Proteins
COPS7A (COP9 Constitutive Photomorphogenic Homolog Subunit 7A (Arabidopsis)): COPS7A anticorps   COPS7A Proteins
COPS7B (COP9 Constitutive Photomorphogenic Homolog Subunit 7B (Arabidopsis)): COPS7B anticorps COPS7B ELISA Kits COPS7B Proteins
COPS8 (COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis)): COPS8 anticorps COPS8 ELISA Kits COPS8 Proteins

SCF Complex

CUL1 - Cullin 1

Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the...   More...
Antigène dans cette catégorie:
SKP1 (S-Phase Kinase-Associated Protein 1): SKP1 anticorps SKP1 ELISA Kits SKP1 Proteins
RBX1 (Ring-Box 1, E3 Ubiquitin Protein Ligase): RBX1 anticorps RBX1 ELISA Kits RBX1 Proteins
BTRC (beta-Transducin Repeat Containing): BTRC anticorps BTRC ELISA Kits BTRC Proteins

DREAM complex

RBL1 - p107

The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene...

RBL2 - p130

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in...

E2F4 (E2F Transcription Factor 4, P107/p130-Binding):

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell...

TFDP1 - DP1

This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and...
Antigène dans cette catégorie:
TFDP2 - DP2: TFDP2 anticorps TFDP2 ELISA Kits TFDP2 Proteins
TFDP3 (Transcription Factor Dp Family, Member 3): TFDP3 anticorps   TFDP3 Proteins
LIN9 (Lin-9 Homolog (C. Elegans)): LIN9 anticorps LIN9 ELISA Kits LIN9 Proteins
LIN37 (Lin-37 Homolog (C. Elegans)): LIN37 anticorps LIN37 ELISA Kits LIN37 Proteins
LIN54 (Lin-54 Homolog (C. Elegans)): LIN54 anticorps LIN54 ELISA Kits LIN54 Proteins
RBBP4 - Retinoblastoma Binding Protein 4: RBBP4 anticorps RBBP4 ELISA Kits RBBP4 Proteins
MSI3 (Histone-Binding Protein RBBP4):   MSI3 ELISA Kits MSI3 Proteins
MYBL1 (Myb-Like Protein 1): MYBL1 anticorps MYBL1 ELISA Kits MYBL1 Proteins
MYBL2 (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2): MYBL2 anticorps MYBL2 ELISA Kits MYBL2 Proteins