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Réparation de l'ADN

L’ADN est le vecteur de l’information génétique constituante de tout être vivant. Le code génétique inscrit dans l’ADN est essentiel dans le processus qui va de la formation des cellules à l’apparence et aux fonctions de l’organisme dans son entier. Toutefois, l’ADN est exposé en permanence aux attaques de nature endogène telles que l’hydrolyse, l’oxydation, l’alkylation, ou les erreurs de réplication. De plus, les radiations ionisantes, les UV, et une pléthore d’agents chimiques constituent des facteurs externes qui menacent l’intégrité de l’ADN.

Contrairement à l’ARN et aux protéines, l’ADN n’est pas dégradé puis re-synthétisé une fois endommagé. En revanche, différentes voies de réparation existent afin de garantir que l’ADN reste intact. En 1974, Francis Crick a fait remarquer que « nous avons complètement négligé le rôle éventuel des enzymes dans la réparation [de l’ADN]. Puis j’en suis venu à la conclusion que l’ADN est tellement précieux qu’il existe probablement de nombreux mécanismes différents. »

Aujourd’hui, cette prédiction s’avère vraie : plus d’un millier de gènes impliqués dans un réseau imbriqué de voies de réparation de l’ADN ont été identifiés depuis. Les dégâts subis par l’ADN peuvent être réparé par l’intermédiaire de six voies différentes, en fonction de la nature de la lésion : les remèdes aux modifications chimiques, aux nucléotides mal incorporés et aux liaisons transversales sont la réparation directe (DR), la réparation par mésappariement (MMR), et la réparation par excision de nucléotides. Les cassures d’un seul brin d’ADN sont réparées grâce à une excision de base. Puis les cassures de doubles brins d’ADN, hautement mutagènes, sont réparées grâce à plusieurs voies complexes qui consistent en une recombinaison homologue (HR) avec les chromatides-sœurs (lors de la phase S ou G2 du cycle cellulaire) ou en une réparation par jonction d'extrémités non homologues (NHEJ) des deux extrémités de la cassure des doubles brins. Lorsque la lésion subie par l’ADN ne peut pas être réparée rapidement, des ADN polymérases spécialisés permettent une synthèse de translésion (TLS) destiné à empêcher la fourche de réplication de l’ADN d’être paralysée. Les mutations qui rendent inopérants les éléments de ces voies de réparation provoquent des maladies telles que le xeroderma pigmentosum, l’ataxie télangiectasie, l’anémie de Fanconi, ainsi qu’une prédisposition au cancer.

Par ailleurs, ces mécanismes de réparation sont d’un intérêt capital pour les approches actuelles d’édition ciblée du génome qui, habituellement, tirent parti de ce mécanisme de réparation cellulaire de l’ADN.

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Canonical Non-Homologous End-Joining

PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide):

This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010].   More...

XRCC6 - X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6

The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions...

XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining)):

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or...
Antigène dans cette catégorie:
ATM (Ataxia Telangiectasia Mutated): ATM anticorps ATM ELISA Kits ATM Proteins
TRIM29 (Tripartite Motif Containing 29): TRIM29 anticorps TRIM29 ELISA Kits TRIM29 Proteins
ATR (Ataxia Telangiectasia and Rad3 Related): ATR anticorps ATR ELISA Kits  
H2AFX - H2A Histone Family, Member X: H2AFX anticorps H2AFX ELISA Kits H2AFX Proteins
XRCC4 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4): XRCC4 anticorps XRCC4 ELISA Kits XRCC4 Proteins
LIG4 - Ligase IV, DNA, ATP-Dependent: LIG4 anticorps LIG4 ELISA Kits LIG4 Proteins
NHEJ1 - Nonhomologous End-Joining Factor 1: NHEJ1 anticorps NHEJ1 ELISA Kits NHEJ1 Proteins
APTX - Aprataxin: APTX anticorps APTX ELISA Kits APTX Proteins
APLF (Aprataxin and PNKP Like Factor): APLF anticorps APLF ELISA Kits APLF Proteins
DCLRE1C (DNA Cross-Link Repair 1C): DCLRE1C anticorps DCLRE1C ELISA Kits DCLRE1C Proteins
PNKP (Polynucleotide Kinase 3'-Phosphatase): PNKP anticorps PNKP ELISA Kits PNKP Proteins
DNTT - Deoxynucleotidyltransferase, terminal: DNTT anticorps DNTT ELISA Kits DNTT Proteins
POLL (Polymerase (DNA Directed), lambda): POLL anticorps POLL ELISA Kits POLL Proteins
POLM - Polymerase (DNA Directed), mu: POLM anticorps   POLM Proteins
MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): MRE11A anticorps MRE11A ELISA Kits MRE11A Proteins
RAD50 (RAD50 Homolog (S. Cerevisiae)): RAD50 anticorps RAD50 ELISA Kits RAD50 Proteins
NBN - Nibrin: NBN anticorps NBN ELISA Kits NBN Proteins
TP53BP1 (Tumor Protein P53 Binding Protein 1): TP53BP1 anticorps TP53BP1 ELISA Kits TP53BP1 Proteins

Microhomology-Mediated End-Joining

PARP1 (Poly (ADP-Ribose) Polymerase 1):

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery...   More...
Antigène dans cette catégorie:
LIG3 (Ligase III, DNA, ATP-Dependent): LIG3 anticorps LIG3 ELISA Kits LIG3 Proteins
LIG2 - Ligase II, DNA, ATP-Dependent:   LIG2 ELISA Kits  
PARP2 - Poly [ADP-Ribose] Polymerase 2:      
PARP2 - Poly (ADP-Ribose) Polymerase 2: PARP2 anticorps PARP2 ELISA Kits PARP2 Proteins
LIG1 (Ligase I, DNA, ATP-Dependent): LIG1 anticorps LIG1 ELISA Kits LIG1 Proteins
ATM (Ataxia Telangiectasia Mutated): ATM anticorps ATM ELISA Kits ATM Proteins
TRIM29 (Tripartite Motif Containing 29): TRIM29 anticorps TRIM29 ELISA Kits TRIM29 Proteins
ATR (Ataxia Telangiectasia and Rad3 Related): ATR anticorps ATR ELISA Kits  
RBBP8 - Retinoblastoma Binding Protein 8: RBBP8 anticorps RBBP8 ELISA Kits RBBP8 Proteins
MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): MRE11A anticorps MRE11A ELISA Kits MRE11A Proteins
RAD50 (RAD50 Homolog (S. Cerevisiae)): RAD50 anticorps RAD50 ELISA Kits RAD50 Proteins
NBN - Nibrin: NBN anticorps NBN ELISA Kits NBN Proteins
RECQL2 - RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding: RECQL2 anticorps RECQL2 ELISA Kits  

Homologous Recombination

RAD51 (DNA Repair Protein Homolog 1):

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of...   More...

BRCA1 (Breast Cancer 1):

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded...

BRCA2 (Breast Cancer 2, Early Onset):

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are...
Antigène dans cette catégorie:
POLE (Polymerase (DNA Directed), Epsilon, Catalytic Subunit): POLE anticorps    
POLE2 - Polymerase (DNA Directed), epsilon 2 (p59 Subunit): POLE2 anticorps POLE2 ELISA Kits POLE2 Proteins
POLE3 - Polymerase (DNA Directed), epsilon 3 (p17 Subunit): POLE3 anticorps POLE3 ELISA Kits POLE3 Proteins
POLE4 (Polymerase (DNA-Directed), epsilon 4 (p12 Subunit)): POLE4 anticorps POLE4 ELISA Kits POLE4 Proteins
POLD1 - Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa: POLD1 anticorps POLD1 ELISA Kits POLD1 Proteins
POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit): POLD2 anticorps POLD2 ELISA Kits POLD2 Proteins
POLD3 - Polymerase (DNA-Directed), delta 3, Accessory Subunit: POLD3 anticorps POLD3 ELISA Kits POLD3 Proteins
POLD4 (Polymerase (DNA-Directed), delta 4, Accessory Subunit): POLD4 anticorps POLD4 ELISA Kits POLD4 Proteins
ATM (Ataxia Telangiectasia Mutated): ATM anticorps ATM ELISA Kits ATM Proteins
TRIM29 (Tripartite Motif Containing 29): TRIM29 anticorps TRIM29 ELISA Kits TRIM29 Proteins
ATR (Ataxia Telangiectasia and Rad3 Related): ATR anticorps ATR ELISA Kits  
Rad51B - RAD51 Homolog B (S. Cerevisiae): Rad51B anticorps   Rad51B Proteins
RAD51C (RAD51 Homolog C (S. Cerevisiae)): RAD51C anticorps RAD51C ELISA Kits RAD51C Proteins
RAD51D - RAD51 Homolog D (S. Cerevisiae): RAD51D anticorps RAD51D ELISA Kits RAD51D Proteins
XRCC1 - XRCC2: XRCC1 anticorps XRCC1 ELISA Kits XRCC1 Proteins
XRCC3 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3): XRCC3 anticorps XRCC3 ELISA Kits XRCC3 Proteins
BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1): BRIP1 anticorps BRIP1 ELISA Kits  
BARD1 (BRCA1 Associated RING Domain 1): BARD1 anticorps BARD1 ELISA Kits BARD1 Proteins
RBBP8 - Retinoblastoma Binding Protein 8: RBBP8 anticorps RBBP8 ELISA Kits RBBP8 Proteins
FAM175A - Family with Sequence Similarity 175, Member A: FAM175A anticorps FAM175A ELISA Kits FAM175A Proteins
UIMC1 - Ubiquitin Interaction Motif Containing 1: UIMC1 anticorps UIMC1 ELISA Kits UIMC1 Proteins
MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): MRE11A anticorps MRE11A ELISA Kits MRE11A Proteins
RAD50 - RAD50:      
RAD50 (RAD50 Homolog (S. Cerevisiae)): RAD50 anticorps RAD50 ELISA Kits RAD50 Proteins
NBN - Nibrin: NBN anticorps NBN ELISA Kits NBN Proteins
TP53BP1 (Tumor Protein P53 Binding Protein 1): TP53BP1 anticorps TP53BP1 ELISA Kits TP53BP1 Proteins
RPA1 - replication protein A1, 70kDa:      
RPA1 - Replication Protein A1, 70kDa: RPA1 anticorps RPA1 ELISA Kits RPA1 Proteins
RPA2 (Replication Protein A2, 32kDa): RPA2 anticorps RPA2 ELISA Kits RPA2 Proteins
RPA3 (Replication Protein A3, 14kDa): RPA3 anticorps   RPA3 Proteins
PALB2 (Partner and Localizer of BRCA2): PALB2 anticorps PALB2 ELISA Kits PALB2 Proteins
TOP3A (Topoisomerase (DNA) III alpha): TOP3A anticorps TOP3A ELISA Kits  
RMI1 (Homolog of Yeast RecQ-mediated Genome Instability 1): RMI1 anticorps RMI1 ELISA Kits RMI1 Proteins
RMI2 (RMI2, RecQ Mediated Genome Instability 2, Homolog (S. Cerevisiae)): RMI2 anticorps RMI2 ELISA Kits RMI2 Proteins
DNA2 (DNA Replication Helicase 2 Homolog (Yeast)): DNA2 anticorps DNA2 ELISA Kits  
RECQL2 - RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding: RECQL2 anticorps RECQL2 ELISA Kits  
RAD54L (RAD54-Like (S. Cerevisiae)): RAD54L anticorps RAD54L ELISA Kits RAD54L Proteins
MUS81 (MUS81 Endonuclease Homolog (S. Cerevisiae)): MUS81 anticorps MUS81 ELISA Kits MUS81 Proteins
EME1 - Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe): EME1 anticorps EME1 ELISA Kits EME1 Proteins
SLX1B - SLX1 Structure-Specific Endonuclease Subunit Homolog B (S. Cerevisiae): SLX1B anticorps SLX1B ELISA Kits SLX1B Proteins
BTBD12 - BTB (POZ) Domain Containing 12: BTBD12 anticorps BTBD12 ELISA Kits  
GEN1 (Gen Endonuclease Homolog 1 (Drosophila)): GEN1 anticorps    

Single Strand Annealing

MSH2 - MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli)

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E....

ERCC1 (Excision Repair Cross Complementing Polypeptide-1):

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced...
Antigène dans cette catégorie:
MSH3 (MutS Homolog 3 (E. Coli)): MSH3 anticorps MSH3 ELISA Kits  
ERCC4 - Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 4: ERCC4 anticorps ERCC4 ELISA Kits  
ATM (Ataxia Telangiectasia Mutated): ATM anticorps ATM ELISA Kits ATM Proteins
TRIM29 (Tripartite Motif Containing 29): TRIM29 anticorps TRIM29 ELISA Kits TRIM29 Proteins
ATR (Ataxia Telangiectasia and Rad3 Related): ATR anticorps ATR ELISA Kits  
MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): MRE11A anticorps MRE11A ELISA Kits MRE11A Proteins
RAD50 (RAD50 Homolog (S. Cerevisiae)): RAD50 anticorps RAD50 ELISA Kits RAD50 Proteins
NBN - Nibrin: NBN anticorps NBN ELISA Kits NBN Proteins
RPA1 - Replication Protein A1, 70kDa: RPA1 anticorps RPA1 ELISA Kits RPA1 Proteins
RPA2 (Replication Protein A2, 32kDa): RPA2 anticorps RPA2 ELISA Kits RPA2 Proteins
RPA3 (Replication Protein A3, 14kDa): RPA3 anticorps   RPA3 Proteins
RAD52 (RAD52 Homolog (S. Cerevisiae)): RAD52 anticorps RAD52 ELISA Kits RAD52 Proteins

Break-Induced Replication

MCM2 - Minichromosome Maintenance Complex Component 2

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of...

MCM7 - Minichromosome Maintenance Complex Component 7

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of...
Antigène dans cette catégorie:
RAD51 (DNA Repair Protein Homolog 1): RAD51 anticorps RAD51 ELISA Kits RAD51 Proteins
MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): MRE11A anticorps MRE11A ELISA Kits MRE11A Proteins
RAD50 (RAD50 Homolog (S. Cerevisiae)): RAD50 anticorps RAD50 ELISA Kits RAD50 Proteins
NBN - Nibrin: NBN anticorps NBN ELISA Kits NBN Proteins
RPA1 - Replication Protein A1, 70kDa: RPA1 anticorps RPA1 ELISA Kits RPA1 Proteins
RPA2 (Replication Protein A2, 32kDa): RPA2 anticorps RPA2 ELISA Kits RPA2 Proteins
RPA3 (Replication Protein A3, 14kDa): RPA3 anticorps   RPA3 Proteins
MCM3 (Minichromosome Maintenance Complex Component 3): MCM3 anticorps MCM3 ELISA Kits MCM3 Proteins
MCM4 (Minichromosome Maintenance Deficient 4): MCM4 anticorps MCM4 ELISA Kits MCM4 Proteins
MCM5 - Minichromosome Maintenance Complex Component 5: MCM5 anticorps MCM5 ELISA Kits MCM5 Proteins
MCM6 - Minichromosome Maintenance Complex Component 6: MCM6 anticorps MCM6 ELISA Kits MCM6 Proteins

Base Excision Repair

OGG1 (8-Oxoguanine DNA Glycosylase):

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the...   More...

UNG (Uracil-DNA Glycosylase):

This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by...

APEX1 - APEX Nuclease (Multifunctional DNA Repair Enzyme) 1

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that...
Antigène dans cette catégorie:
MPG - N-Methylpurine-DNA Glycosylase: MPG anticorps MPG ELISA Kits MPG Proteins
SMUG1 - Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1: SMUG1 anticorps SMUG1 ELISA Kits SMUG1 Proteins
TDG - Thymine-DNA Glycosylase: TDG anticorps TDG ELISA Kits TDG Proteins
MBD4 (Methyl-CpG Binding Domain Protein 4): MBD4 anticorps MBD4 ELISA Kits MBD4 Proteins
MUTYH - MutY Homolog (E. Coli): MUTYH anticorps MUTYH ELISA Kits MUTYH Proteins
NTHL1 - NTH1: NTHL1 anticorps NTHL1 ELISA Kits  
NEIL1 (Endonuclease VIII-Like 1): NEIL1 anticorps NEIL1 ELISA Kits NEIL1 Proteins
NEIL2 (Nei Endonuclease VIII-Like 2 (E. Coli)): NEIL2 anticorps NEIL2 ELISA Kits NEIL2 Proteins
NEIL3 (Nei Endonuclease VIII-Like 3 (E. Coli)): NEIL3 anticorps NEIL3 ELISA Kits NEIL3 Proteins
POLB (Polymerase (DNA Directed), beta): POLB anticorps POLB ELISA Kits POLB Proteins
POLD1 - Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa: POLD1 anticorps POLD1 ELISA Kits POLD1 Proteins
POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit): POLD2 anticorps POLD2 ELISA Kits POLD2 Proteins
POLD3 - Polymerase (DNA-Directed), delta 3, Accessory Subunit: POLD3 anticorps POLD3 ELISA Kits POLD3 Proteins
POLD4 (Polymerase (DNA-Directed), delta 4, Accessory Subunit): POLD4 anticorps POLD4 ELISA Kits POLD4 Proteins
FEN1 (Flap Structure-Specific Endonuclease 1): FEN1 anticorps FEN1 ELISA Kits FEN1 Proteins
LIG1 (Ligase I, DNA, ATP-Dependent): LIG1 anticorps LIG1 ELISA Kits LIG1 Proteins

Nuleotide Excision Repair

POLR2B - Polymerase (RNA) II (DNA Directed) Polypeptide B, 140kDa

This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA. [provided by RefSeq, Jul 2008].   More...

XPC (Xeroderma Pigmentosum, Complementation Group C):

This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including...

DDB1 (Damage-Specific DNA Binding Protein 1, 127kDa):

The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48)...
Antigène dans cette catégorie:
XPA (Xeroderma Pigmentosum, Complementation Group A): XPA anticorps XPA ELISA Kits XPA Proteins
RAD23A (RAD23 Homolog A (S. Cerevisiae)): RAD23A anticorps RAD23A ELISA Kits RAD23A Proteins
RAD23B - RAD23 Homolog B (S. Cerevisiae): RAD23B anticorps RAD23B ELISA Kits RAD23B Proteins
CETN2 (Centrin, EF-Hand Protein, 2): CETN2 anticorps CETN2 ELISA Kits CETN2 Proteins
DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa): DDB2 anticorps DDB2 ELISA Kits DDB2 Proteins
ERCC1 (Excision Repair Cross Complementing Polypeptide-1): ERCC1 anticorps ERCC1 ELISA Kits ERCC1 Proteins
ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2): ERCC2 anticorps ERCC2 ELISA Kits ERCC2 Proteins
ERCC3 - DNA Repair Protein Complementing XP-B Cells: ERCC3 anticorps ERCC3 ELISA Kits ERCC3 Proteins
XP-B - Xeroderma Pigmentosum, Complementation Group B:   XP-B ELISA Kits  
GTF2H1 - General Transcription Factor IIH, Polypeptide 1, 62kDa: GTF2H1 anticorps GTF2H1 ELISA Kits GTF2H1 Proteins
GTF2H4 (General Transcription Factor IIH, Polypeptide 4, 52kDa): GTF2H4 anticorps   GTF2H4 Proteins
GTF2H3 (General Transcription Factor IIH, Polypeptide 3, 34kD): GTF2H3 anticorps GTF2H3 ELISA Kits GTF2H3 Proteins
GTF2H5 - General Transcription Factor IIH, Polypeptide 5: GTF2H5 anticorps GTF2H5 ELISA Kits GTF2H5 Proteins
CDK7 (Cyclin-Dependent Kinase 7): CDK7 anticorps CDK7 ELISA Kits CDK7 Proteins
RFC1 - Replication Factor C (Activator 1) 1, 145kDa: RFC1 anticorps RFC1 ELISA Kits RFC1 Proteins
RFC2 (Replication Factor C (Activator 1) 2, 40kDa): RFC2 anticorps RFC2 ELISA Kits RFC2 Proteins
RFC3 - Replication Factor C (Activator 1) 3, 38kDa: RFC3 anticorps RFC3 ELISA Kits RFC3 Proteins
RFC4 (Replication Factor C (Activator 1) 4, 37kDa): RFC4 anticorps RFC4 ELISA Kits RFC4 Proteins
RFC5 (Replication Factor C (Activator 1) 5, 36.5kDa): RFC5 anticorps RFC5 ELISA Kits RFC5 Proteins
POLK - Polymerase (DNA Directed) kappa: POLK anticorps POLK ELISA Kits POLK Proteins
ERCC4 - Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 4: ERCC4 anticorps ERCC4 ELISA Kits  
ERCC5 - DNA Repair Protein Complementing XP-G Cells: ERCC5 anticorps ERCC5 ELISA Kits ERCC5 Proteins
ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6): ERCC6 anticorps   ERCC6 Proteins
ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8): ERCC8 anticorps ERCC8 ELISA Kits ERCC8 Proteins
POLE (Polymerase (DNA Directed), Epsilon, Catalytic Subunit): POLE anticorps    
POLE2 - Polymerase (DNA Directed), epsilon 2 (p59 Subunit): POLE2 anticorps POLE2 ELISA Kits POLE2 Proteins
POLE3 - Polymerase (DNA Directed), epsilon 3 (p17 Subunit): POLE3 anticorps POLE3 ELISA Kits POLE3 Proteins
POLE4 (Polymerase (DNA-Directed), epsilon 4 (p12 Subunit)): POLE4 anticorps POLE4 ELISA Kits POLE4 Proteins
PCNA (Proliferating Cell Nuclear Antigen): PCNA anticorps PCNA ELISA Kits PCNA Proteins
XRCC1 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1): XRCC1 anticorps XRCC1 ELISA Kits XRCC1 Proteins
FEN1 (Flap Structure-Specific Endonuclease 1): FEN1 anticorps FEN1 ELISA Kits FEN1 Proteins
LIG1 (Ligase I, DNA, ATP-Dependent): LIG1 anticorps LIG1 ELISA Kits LIG1 Proteins
RPA1 - Replication Protein A1, 70kDa: RPA1 anticorps RPA1 ELISA Kits RPA1 Proteins
RPA2 (Replication Protein A2, 32kDa): RPA2 anticorps RPA2 ELISA Kits RPA2 Proteins
RPA3 (Replication Protein A3, 14kDa): RPA3 anticorps   RPA3 Proteins

Mismatch Repair

MSH2 - MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli)

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].   More...

MSH3 (MutS Homolog 3 (E. Coli)):

The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS...

MSH6 (MutS Homolog 6 (E. Coli)):

This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to...
Antigène dans cette catégorie:
MLH1 (MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli)): MLH1 anticorps MLH1 ELISA Kits MLH1 Proteins
PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae)): PMS2 anticorps PMS2 ELISA Kits PMS2 Proteins
RFC1 - Replication Factor C (Activator 1) 1, 145kDa: RFC1 anticorps RFC1 ELISA Kits RFC1 Proteins
RFC2 (Replication Factor C (Activator 1) 2, 40kDa): RFC2 anticorps RFC2 ELISA Kits RFC2 Proteins
RFC3 - Replication Factor C (Activator 1) 3, 38kDa: RFC3 anticorps RFC3 ELISA Kits RFC3 Proteins
RFC4 (Replication Factor C (Activator 1) 4, 37kDa): RFC4 anticorps RFC4 ELISA Kits RFC4 Proteins
RFC5 (Replication Factor C (Activator 1) 5, 36.5kDa): RFC5 anticorps RFC5 ELISA Kits RFC5 Proteins
POLD1 - Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa: POLD1 anticorps POLD1 ELISA Kits POLD1 Proteins
POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit): POLD2 anticorps POLD2 ELISA Kits POLD2 Proteins
POLD3 - Polymerase (DNA-Directed), delta 3, Accessory Subunit: POLD3 anticorps POLD3 ELISA Kits POLD3 Proteins
PCNA (Proliferating Cell Nuclear Antigen): PCNA anticorps PCNA ELISA Kits PCNA Proteins
LIG1 (Ligase I, DNA, ATP-Dependent): LIG1 anticorps LIG1 ELISA Kits LIG1 Proteins
RPA1 - Replication Protein A1, 70kDa: RPA1 anticorps RPA1 ELISA Kits RPA1 Proteins
RPA2 (Replication Protein A2, 32kDa): RPA2 anticorps RPA2 ELISA Kits RPA2 Proteins
RPA3 (Replication Protein A3, 14kDa): RPA3 anticorps   RPA3 Proteins
EXO1 - Exonuclease 1: EXO1 anticorps EXO1 ELISA Kits EXO1 Proteins

Direct Reversal

MGMT (O6-Methylguanine-DNA-Methyltransferase):

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a   More...

ALKBH - AlkB, Alkylation Repair Homolog 1 (E. Coli)

This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation...

ALKBH2 - AlkB, Alkylation Repair Homolog 2

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in...
Antigène dans cette catégorie:
ALKBH3 - AlkB, Alkylation Repair Homolog 3 (E. Coli): ALKBH3 anticorps ALKBH3 ELISA Kits ALKBH3 Proteins

Trans-Lesion Synthesis

POLI - Polymerase (DNA Directed) iota

Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity...

POLH - Polymerase (DNA Directed), eta

This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed...
Antigène dans cette catégorie:
REV3L (REV3-Like, Polymerase (DNA Directed), Zeta, Catalytic Subunit): REV3L anticorps    
REV1 (REV1, Polymerase (DNA Directed)): REV1 anticorps REV1 ELISA Kits REV1 Proteins
POLK - Polymerase (DNA Directed) kappa: POLK anticorps POLK ELISA Kits POLK Proteins
PCNA (Proliferating Cell Nuclear Antigen): PCNA anticorps PCNA ELISA Kits PCNA Proteins