anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) Anticorps

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

1. Genotyping of ABCB1 variants can help to prevent severe adverse reactions to irinotecan-based treatments in colorectal cancer.

2. Our results suggested that the in vitro efficacy of anticancer drugs on the proliferation of colon cancer cells was significantly affected by P-gp in cancer cell lines abundantly expressing P-gp, accounting for 1.5% of cancer cell lines of all cancer types and 14.5% of colon cancer cell lines in the Cancer Cell Line Encyclopedia.

3. Pgp expression was associated with an increase in the proinflammatory nature of CD8+ cells in bronchiolitis obliterans syndrome

4. Genotype distribution was in Hardy-Weinberg equilibrium for all three ABCB1polymorphisms. For c.1236C>T and c.3435C>T, the heterozygous C/T was the most frequent genotype, while heterozygous G/T was the most common genotype for c.2677G>T/A, mainly followed by G/G and T/T. 12 haplotypes were estimated from the three ABCB1 polymorphisms analyzed, with TTT the most frequent haplotype.

5. This study aimed to explore the connection between the 10-hydroxycarbazepine concentration and genes such as ATP-binding cassette B1 (ABCB1), ATP-binding cassette C2 (ABCC2), UDP-glucuronosyltransferase-2B7 and sodium voltage-gated channel alpha subunit 2 (SCN2A), which participate in the antiepileptic function of oxcarbazepine

6. Study identified that the miRNA149 contributes to the development of multidrug resistance within malignant mesothelioma cells by regulating the expression of MDR1.

7. findings suggest that ABCA1 and ABCB1 proteins display similar arsenic resistance capabilities and possibly coordinate to promote arsenic resistance in AsRE cells

8. Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer have been reported.

9. ABCB1 polymorphism C3435T may contribute to potential life-threatening infections during paediatric acute lymophoblastic leukemia therapy, through glucocorticoid usage.

10. TIPE2 sensitizes osteosarcoma cells to cis-platin through downregulation of MDR1 and may be a novel target in osteosarcoma therapy.

11. The role of ABCB1 polymorphism as a prognostic marker for primary central nervous system lymphoma.

12. ABCB1 C1236T, ABCB1 G2677 T/A genotype and BMI are probably the factors influencing the clinical efficacy of tacrolimus in treating patients with nephrotic syndrome .

13. upregulation of ABCB1 can be considered as the crucial component of poor response to oxaliplatin which is likely controlled by miR-302c-5p.

14. There was about 50% reduction on cells migration when MDR1 gene was down-regulated.

15. Leukemic cells unable to achieve complete response (CR) showed an increased expression of MDR1 and P-gp, compared to patients who achieved CR

16. MDR13435T variant allele might be more efficient to transport carbamazepine, whereas reduces the efflux activity of P-gp-mediated phenobarbital. Collectively, MDR1 (C3435T) polymorphism might impact the P-gp activity and antiepileptic agents efflux with drug specificity.

17. To understand the role of transmembrane helices (TMH) 1 and 7 in drug-binding and transport, we selected six residues from both TMH1 (V53, I59, I60, L65, M68 and F72) and TMH7 (V713, I719, I720, Q725, F728 and F732); and substituted them with alanine by gene synthesis to generate a variant termed "TMH1,7 mutant P-gp". TMH1 and TMH7 play a critical role in the drug efflux function of this multidrug transporter.

18. data revealed that despite a strong influence to down-regulate the MDR1 expression, Resveratrol and Prednisolone did not alter the methylation pattern, suggesting other regulatory mechanisms in controlling the MDR1 expression in CCRF-CEM cell line.

19. findings show a limited influence of ABCB1 genotype on lenalidomide treatment efficacy and safety. The results suggest that 1199G>A may be a marker of time to progression following Len treatment in standard-risk patients

20. CT genotype of C3435T of MDR-1 Gene is associated with Acute Lymphoblastic Leukemia.

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

1. esults suggest that P-gp plays important role in mediating rivastigmine non-cholinergic beneficial effects, including Abeta brain load reduction, neuroprotective and anti-inflammatory effects in the AD mouse models.

2. this study shows that MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation

3. A panel of 18 P-gp substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp can affect the pulmonary kinetics of a subset of P-gp substrates.

4. Data suggest that the overexpression of P-gp in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.

5. We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.

6. Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp, multi-drug resistance protein, MDR1).Drugs with ER < 1 almost do not bind the main binding cavity (MBC) of P-gp.

7. conclusion, MDR1 and BCRP are expressed on apical membranes of the rodent placental SynT-II layer.

8. Mdr1 enforces T Cell homeostasis in the presence of intestinal bile acids.

9. Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.

10. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity

11. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

12. Chrysosplenetin inhibited P-gp activity and reverse the up-regulated P-gp and MDR1 levels induced by artemisinin.

13. Tamsulosin and tolterodine with P-gp gene expression and activity in an enantiomer-specific way.

14. Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.

15. Data show that human transgenic mutant huntingtin (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1) which suggests that MDR1 might be a potential therapeutic target for Huntington's disease.

16. In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin

17. Efficient chemoprotection of CDD and MDR1 transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara-C and anthracycline application

18. Mdr1b participates in the elimination of paraquat from the kidneys and protects against subsequent toxicity.

19. These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1-1Delta mutant mice following exposure to various P-gp substrates.

20. Data indicate that the brain penetration of ABT-888 in both Abcb1a/1b-/- and Abcb1a/1b-/-;Abcg2-/- mice was significantly higher than in wild-type mice.