anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) Anticorps

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

1. WBP2 directly promoted P-glycoprotein expression through binding to ERalpha to increase the doxorubicin resistance of ERalpha-positive MCF-7 cells.

2. this study shows that high MDR-1 expression by mucosal-associated invariant T cells confers resistance to cytotoxic but not immunosuppressive MDR-1 substrates

3. A correlation exists between the ABCB1 C3435T gene polymorphism and post-stroke depression in the Han population in South Anhui province, China.

4. elevated levels of ABCB1 gene expression are associated with response to metformin with chemotherapy in acute lymphoblastic leukemia

5. There was no significant association between Tac-related nephrotoxicity and donor CYP3A5 and ABCB1 genotype.

6. WYE354 stimulated the ATPase activity of ABCB1, which was consistent with in silico predictions using a human ABCB1 mouse homology model, indicating that WYE354 is a potent substrate of ABCB1.

7. ABCB1 is involved in neo-absorbed vitamin D efflux by the enterocytes and that it also contributes to vitamin D transintestinal excretion and likely impacts vitamin D status.

8. this study determined the 3.5-angstrom cryo-electron microscopy structure of substrate-bound human ABCB1 reconstituted in lipidic nanodiscs, revealing a single molecule of the chemotherapeutic compound paclitaxel (Taxol) bound in a central, occluded pocket.

9. CCL20 enhanced doxorubicin resistance of OC cells by regulating ABCB1 expression

10. MDR1 (rs1045642) and CYP46A1 (rs754203) genes polymorphism was not found associated with Fasting Blood Sugar (FBS), Diastolic Blood Pressure (DBP) or Systolic Blood Pressure (SBP).

11. The rs1799971 and rs1323040 polymorphisms of the OPRM1 gene and rs2032582 and rs1128503 polymorphisms of the ABCB1 gene are related to the analgesic effect and consumed dose of sufentanil in Chinese Han patients undergoing radical operation of lung cancer.

12. We demonstrate that decreased HER2 and upregulation of MDR1 contribute to T-DM1 resistance in KPL-4 T-DM1-resistant cells.

13. Ubenimex Reverses MDR in Gastric Cancer Cells by Activating Caspase-3-Mediated Apoptosis and Suppressing the Expression of Membrane Transport Proteins.

14. The variant allele of ABCB1 3435C>T polymorphism could be a potential predictive biomarker of docetaxel-induced rash, and homozygous wild-type ABCB1 2677G>A/T might predict for a greater risk of fatigue

15. ABCB1 genetic variation influences P-gp activity or expression and predisposition for bipolar disorder and schizophrenia in the Macedonian population.

16. The characterization of CYP3A4*1B and 3435C>T MDR1 polymorphism cannot provide useful guidance for individualizing cyclosporine A dosages in renal transplant patients by indicating the optimal dose of these drugs without exposing patients to possible adverse effects associated mainly with nephrotoxicity.

17. analysis of seven polymorphisms in genes of folate transport and (de)glutamation pathway on methotrexate polyglutamate levels and response in patients with rheumatoid arthritis: ABCB1, FPGS, GGH and RFC1

18. the results suggest a possible genetic contribution of single-nucleotide polymorphisms within the ABCB1 and COMT genes in individuals with higher levels of pain sensitivity

19. ABCB1 genetic polymorphisms affect aripiprazole-related autonomic nervous system dysfunction in patients treated for schizophrenia.

20. RPN2 potentiated P-gp- and ABCG2-mediated MDR via activating MEK/ERK pathway in GC

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

1. ABCB1 is involved in neo-absorbed vitamin D efflux by the enterocytes and that it also contributes to vitamin D transintestinal excretion and likely impacts vitamin D status.

2. esults suggest that P-gp plays important role in mediating rivastigmine non-cholinergic beneficial effects, including Abeta brain load reduction, neuroprotective and anti-inflammatory effects in the AD mouse models.

3. this study shows that MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation

4. A panel of 18 P-gp substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp can affect the pulmonary kinetics of a subset of P-gp substrates.

5. Data suggest that the overexpression of P-gp in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.

6. We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.

7. Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp, multi-drug resistance protein, MDR1).Drugs with ER < 1 almost do not bind the main binding cavity (MBC) of P-gp.

8. conclusion, MDR1 and BCRP are expressed on apical membranes of the rodent placental SynT-II layer.

9. Mdr1 enforces T Cell homeostasis in the presence of intestinal bile acids.

10. Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.

11. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity

12. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

13. Chrysosplenetin inhibited P-gp activity and reverse the up-regulated P-gp and MDR1 levels induced by artemisinin.

14. Tamsulosin and tolterodine with P-gp gene expression and activity in an enantiomer-specific way.

15. Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.

16. Data show that human transgenic mutant huntingtin (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1) which suggests that MDR1 might be a potential therapeutic target for Huntington's disease.

17. In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin

18. Efficient chemoprotection of CDD and MDR1 transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara-C and anthracycline application

19. Mdr1b participates in the elimination of paraquat from the kidneys and protects against subsequent toxicity.

20. These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1-1Delta mutant mice following exposure to various P-gp substrates.