anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) Anticorps

The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. De plus, nous expédions ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Protéines (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
ABCB1B 5243 P08183
ABCB1B 18669 P06795
ABCB1B 24646  
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Top anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Anticorps sur anticorps-enligne.fr

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Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué ICC, IF, IHC (p) Immunofluorescence analysis of mouse kidney tissue using anti-MDR1 (dilution of primary antibody - 1:1000) Immunohistochemical staining of paraffin embedded mouse kidney tissue using anti-MDR1 (primary antibody at 1:1000) 100 μg Connectez-vous pour afficher 10 to 15 Days
$521.89
Détails
Humain Lapin Inconjugué FACS, IF (p), IHC (p) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-MDR1/p-GP/CD243 Polyclonal Antibody (ABIN670161), Unconjugated 1:200 at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-MDR1/p-GP/CD243 Polyclonal Antibody , Unconjugated 1:200 at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Connectez-vous pour afficher 3 to 7 Days
$329.45
Détails
Humain Souris Inconjugué IF, IP, WB   100 μL Connectez-vous pour afficher 11 to 13 Days
$405.08
Détails
Humain Souris Inconjugué FACS, IF, IHC, WB   500 μL Connectez-vous pour afficher 11 to 16 Days
$732.29
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Humain Lapin Inconjugué IHC   50 μg Connectez-vous pour afficher 11 to 16 Days
$762.14
Détails
Humain Souris Inconjugué IC, IHC, WB   100 μg Connectez-vous pour afficher 11 to 16 Days
$587.71
Détails
Humain Souris Inconjugué FACS, IHC, WB   100 μL Connectez-vous pour afficher 11 to 16 Days
$762.14
Détails
Humain Souris Inconjugué IC, FACS, IHC, WB   250 μg Connectez-vous pour afficher 11 to 16 Days
$843.86
Détails
Humain Rat Inconjugué IC, FACS, IHC, WB   125 μg Connectez-vous pour afficher 11 to 16 Days
$861.14
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Humain Souris Inconjugué IC, FACS, IHC, WB   250 μg Connectez-vous pour afficher 11 to 16 Days
$1,335.71
Détails

anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Anticorps mieux référencés

  1. Human Polyclonal ABCB1B Primary Antibody pour FACS, IF (p) - ABIN670161 : Hu, Peng, Li: The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer. dans Journal of experimental & clinical cancer research : CR 2009 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B partenaires d’interaction

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

  1. analysis of seven polymorphisms in genes of folate transport and (de)glutamation pathway on methotrexate polyglutamate levels and response in patients with rheumatoid arthritis: ABCB1, FPGS, GGH and RFC1

  2. the results suggest a possible genetic contribution of single-nucleotide polymorphisms within the ABCB1 and COMT genes in individuals with higher levels of pain sensitivity

  3. ABCB1 genetic polymorphisms affect aripiprazole-related autonomic nervous system dysfunction in patients treated for schizophrenia.

  4. RPN2 potentiated P-gp- and ABCG2-mediated MDR via activating MEK/ERK pathway in GC

  5. MDR-1 genetic variants were not associated with treatment resistance when compared to responders to clopidogrel therapy.

  6. BEL repressed rifampicin-induced gene expression of CYP3A4 and multidrug resistance protein 1, as well as their respective protein activities.

  7. Patients with low OCT-1 activity and high ABCB1 fold rise have poor long-term outcomes.

  8. The data presented herein demonstrate that the P-glycoprotein mRNA transcript is regulated by cooperation between miR-19b and the RNA-binding protein HuR

  9. High ABCB1 expression is associated with vinorelbine resistance in lung cancer.

  10. The studied polymorphism in ABCB1 does not seem to affect the increased risk of multiple myeloma development.

  11. Dual luciferase activity assay demonstrated that ZNF139 inhibited transcriptional activities of miR-185's promoter in cells transfected with the reporter plasmid encompassing the upstream promoter region of miR-185 along with pcDNA-ZNF139. Our data reveal that ZNF139 might promote MDR gene MDR1/P-gp, MRP-1 and Bcl-2 by prohibiting miR-185

  12. The ABCB1 (C1236T) polymorphism affects P-gp-mediated transport of osteosarcoma drugs in a drug-specific way

  13. MDR1 overexpression enhanced the viability and doxorubicin resistance of colon cancer cells.

  14. The carriage of ABCB1 mutant allele was not significantly associated with clopidogrel resistance risk.

  15. Genotyping of ABCB1 variants can help to prevent severe adverse reactions to irinotecan-based treatments in colorectal cancer.

  16. Our results suggested that the in vitro efficacy of anticancer drugs on the proliferation of colon cancer cells was significantly affected by P-gp in cancer cell lines abundantly expressing P-gp, accounting for 1.5% of cancer cell lines of all cancer types and 14.5% of colon cancer cell lines in the Cancer Cell Line Encyclopedia.

  17. Pgp expression was associated with an increase in the proinflammatory nature of CD8+ cells in bronchiolitis obliterans syndrome

  18. Genotype distribution was in Hardy-Weinberg equilibrium for all three ABCB1polymorphisms. For c.1236C>T and c.3435C>T, the heterozygous C/T was the most frequent genotype, while heterozygous G/T was the most common genotype for c.2677G>T/A, mainly followed by G/G and T/T. 12 haplotypes were estimated from the three ABCB1 polymorphisms analyzed, with TTT the most frequent haplotype.

  19. This study aimed to explore the connection between the 10-hydroxycarbazepine concentration and genes such as ATP-binding cassette B1 (ABCB1), ATP-binding cassette C2 (ABCC2), UDP-glucuronosyltransferase-2B7 and sodium voltage-gated channel alpha subunit 2 (SCN2A), which participate in the antiepileptic function of oxcarbazepine

  20. Study identified that the miRNA149 contributes to the development of multidrug resistance within malignant mesothelioma cells by regulating the expression of MDR1.

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

  1. esults suggest that P-gp plays important role in mediating rivastigmine non-cholinergic beneficial effects, including Abeta brain load reduction, neuroprotective and anti-inflammatory effects in the AD mouse models.

  2. this study shows that MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation

  3. A panel of 18 P-gp substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp can affect the pulmonary kinetics of a subset of P-gp substrates.

  4. Data suggest that the overexpression of P-gp in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.

  5. We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.

  6. Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp, multi-drug resistance protein, MDR1).Drugs with ER < 1 almost do not bind the main binding cavity (MBC) of P-gp.

  7. conclusion, MDR1 and BCRP are expressed on apical membranes of the rodent placental SynT-II layer.

  8. Mdr1 enforces T Cell homeostasis in the presence of intestinal bile acids.

  9. Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.

  10. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity

  11. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

  12. Chrysosplenetin inhibited P-gp activity and reverse the up-regulated P-gp and MDR1 levels induced by artemisinin.

  13. Tamsulosin and tolterodine with P-gp gene expression and activity in an enantiomer-specific way.

  14. Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.

  15. Data show that human transgenic mutant huntingtin (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1) which suggests that MDR1 might be a potential therapeutic target for Huntington's disease.

  16. In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin

  17. Efficient chemoprotection of CDD and MDR1 transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara-C and anthracycline application

  18. Mdr1b participates in the elimination of paraquat from the kidneys and protects against subsequent toxicity.

  19. These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1-1Delta mutant mice following exposure to various P-gp substrates.

  20. Data indicate that the brain penetration of ABT-888 in both Abcb1a/1b-/- and Abcb1a/1b-/-;Abcg2-/- mice was significantly higher than in wild-type mice.

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) profil antigène

Profil protéine

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene names and symbols associated with ABCB1B

  • ATP binding cassette subfamily B member 1 (ABCB1) anticorps
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b) anticorps
  • ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b) anticorps
  • ABC20 anticorps
  • Abcb1 anticorps
  • CD243 anticorps
  • CLCS anticorps
  • GP170 anticorps
  • mdr anticorps
  • Mdr1 anticorps
  • Mdr1b anticorps
  • P-GP anticorps
  • Pgy-1 anticorps
  • Pgy1 anticorps

Protein level used designations for ABCB1B

P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , multidrug resistance protein 1 , ATP-binding cassette sub-family B member 1 , P glycoprotein 1 , multidrug resistance protein 1B , ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1B , ATP-binding cassette, subfamily B, member 1B , P-glycoprotein/multidrug resistance 1

GENE ID SPECIES
5243 Homo sapiens
18669 Mus musculus
24646 Rattus norvegicus
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