anti-BRCA2 and CDKN1A Interacting Protein (BCCIP) Anticorps

BCCIP product was isolated on the basis of its interaction with BRCA2 and p21 proteins. De plus, nous expédions BCCIP Protéines (10) et BCCIP Kits (5) et beaucoup plus de produits pour cette protéine.

Gène	GeneID	UniProt
BCCIP	56647	Q9P287
BCCIP	66165	Q9CWI3
BCCIP	361666

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Showing 10 out of 51 products:

Catalogue No.	Reactivité	Hôte	Conjugué	Application	Quantité	Fournisseur	Livraison	Prix	Détails
ABIN3059966	Humain	Lapin	Inconjugué	IHC, WB	100 μL	Connectez-vous pour afficher	11 to 16 Days	$426.40	Détails
ABIN2856892	Humain	Lapin	Inconjugué	ICC, IF, IHC (p), WB	100 μL	Connectez-vous pour afficher	1 to 2 Days	$358.60	Détails
ABIN441326	Humain	Lapin	Inconjugué	ICC, IF, IHC, IHC (p), WB	100 μL	Connectez-vous pour afficher	8 to 11 Days	$514.63	Détails
ABIN439676	Humain	Lapin	Inconjugué	IHC (p), IP, IHC	100 μL	Connectez-vous pour afficher	7 to 9 Days	$556.31	Détails
ABIN439675	Humain	Lapin	Inconjugué	ICC, IF, IHC (p), IP, IHC, WB	0.1 mL	Connectez-vous pour afficher	7 to 9 Days	$556.31	Détails
ABIN6284594	Humain	Lapin	Inconjugué	ELISA, WB	200 μL	Connectez-vous pour afficher	16 Days	$221.38	Détails
ABIN6260217	Humain	Lapin	Inconjugué	ELISA, ICC, IF, WB	100 μL	Connectez-vous pour afficher	11 to 12 Days	$390.77	Détails
ABIN527935	Humain	Souris	Inconjugué	IF, WB	50 μL	Connectez-vous pour afficher	11 to 12 Days	$440.00	Détails
ABIN1832167	Humain	Souris	Inconjugué	DB	50 μg	Connectez-vous pour afficher	7 to 9 Days	$493.17	Détails
ABIN1833762	Humain	Lapin	Inconjugué	ICC, IHC, IHC (p), WB	100 μL	Connectez-vous pour afficher	7 to 9 Days	$507.83	Détails

BCCIP Anticorps par réactivité, application, clonalité et conjugué

Attributs	Application	Hôte	Clonalité	Conjugué
Human	, , , ,	,	,	, , , , , , , , , , , , ,
Mouse (Murine)	,			, , , , , , , , , , , , ,
Rat (Rattus)	,			, , , , , , , , , , , , ,

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Plus d’anticorps contre BCCIP partenaires d’interaction

Human BRCA2 and CDKN1A Interacting Protein (BCCIP) interaction partners

We analyzed the BCCIP protein level in 470 cases of human breast cancer to determine the associations between BCCIP and 53BP1 (Montrer TP53BP1 Anticorps), p53 (Montrer TP53 Anticorps), and subtypes of breast cancer. We further constructed a unique BCCIP knockdown mouse model to determine whether a partial BCCIP deficiency leads to spontaneous breast cancer formation
BCCIPbeta, as a S7 modulator, contributes to the regulation of ribosomal and extraribosomal functions of S7 and has implications in cell growth and tumor development.
this study identifies BCCIP as a novel factor critical for microtubule regulation and explicates a mechanism utilized by BCCIP in tumor suppression.
Expression of BCCIP beta was notably higher in tumor tissues of esophageal squamous cell carcinoma (ESCC) and Eca 109 cells. In vitro studies such as starvation and refeeding assay along with BCCIP beta-shRNA transfection assay demonstrated that BCCIP beta expression promoted proliferation of ESCC cells.
we demonstrate that BCCIPbeta induces a conformational change within the RAD51 (Montrer RAD51 Anticorps) filament that promotes release of ADP to help maintain an active presynaptic filament. Our findings reveal a functional role for BCCIPbeta as a RAD51 (Montrer RAD51 Anticorps) accessory factor in HR.
the existence of both INO80 (Montrer INO80 Anticorps) and YY1 (Montrer YY1 Anticorps) is required for recruiting the INO80 (Montrer INO80 Anticorps)/YY1 (Montrer YY1 Anticorps) complex to BCCIP promoter region. Our findings strongly indicate that BCCIP is a potential target gene of the INO80 (Montrer INO80 Anticorps)/YY1 (Montrer YY1 Anticorps) complex.
The BCCIPbeta, but not BCCIPalpha, interacts with EIF6 (Montrer EIF6 Anticorps) and RPL23 (Montrer RPL17 Anticorps)/UL14 and stabilizes the latter.
Results indicate that BCCIP germ line mutations are unlikely to be a major contributor to familial breast/ovarian cancer risk in our population.
In BRCA2 (Montrer BRCA2 Anticorps), two novel frame shift mutations were identified as 5073-5074delCT and 6866delC.
BRCA2 (Montrer BRCA2 Anticorps) germline mutations appear to have a milder clinical phenotype when compared to non-BRCA2 (Montrer BRCA2 Anticorps) mutations, since survival is higher among breast cancer patients carrying a BRCA2 (Montrer BRCA2 Anticorps) mutation compared to sporadic breast cancers.

Mouse (Murine) BRCA2 and CDKN1A Interacting Protein (BCCIP) interaction partners

We analyzed the BCCIP protein level in 470 cases of human breast cancer to determine the associations between BCCIP and 53BP1 (Montrer TP53BP1 Anticorps), p53 (Montrer TP53 Anticorps), and subtypes of breast cancer. We further constructed a unique BCCIP knockdown mouse model to determine whether a partial BCCIP deficiency leads to spontaneous breast cancer formation
BCCIP represents a paradoxical class of modulators for tumorigenesis as a suppressor for initiation but a requisite for progression.
BCCIP and its anti-replication stress functions are essential for normal neural development by maintaining an orderly proliferation of neural progenitors.
these data suggest a unique function of BCCIP, not only in repair of DNA damage, but also in resolving stalled replication forks and prevention of replication stress

BCCIP profil antigène

Profil protéine

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with BCCIP

BRCA2 and CDKN1A interacting protein (BCCIP) anticorps
BRCA2 and CDKN1A interacting protein (bccip) anticorps
BRCA2 and CDKN1A interacting protein L homeolog (bccip.L) anticorps
BRCA2 and CDKN1A interacting protein (Bccip) anticorps

1110013J05Rik anticorps
BCCIP anticorps
DKFZp459K2416 anticorps
MGC82792 anticorps
MGC89311 anticorps
mp:zf637-1-000774 anticorps
TOK-1 anticorps
TOK1 anticorps
zgc:110272 anticorps

Protein level used designations for BCCIP

BRCA2 and CDKN1A interacting protein , protein BCCIP homolog , BRCA2 and CDKN1A-interacting protein , bccip-like , BCCIPalpha , BCCIPbeta , BRCA2 and Cip1/p21 interacting protein , TOK-1alpha , TOK-1beta , cdk inhibitor p21 binding protein , p21- and CDK-associated protein 1 , protein TOK-1

GENE ID	SPECIES
426225	Gallus gallus
541348	Danio rerio
738638	Pan troglodytes
100173923	Pongo abelii
100528563	Ictalurus punctatus
444344	Xenopus laevis
448392	Xenopus (Silurana) tropicalis
56647	Homo sapiens
66165	Mus musculus
512466	Bos taurus
477864	Canis lupus familiaris
100157478	Sus scrofa
361666	Rattus norvegicus

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