Profil protéine

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with BCCIP

• BRCA2 and CDKN1A interacting protein (BCCIP) anticorps
• BRCA2 and CDKN1A interacting protein (bccip) anticorps
• BRCA2 and CDKN1A interacting protein L homeolog (bccip.L) anticorps
• BRCA2 and CDKN1A interacting protein (Bccip) anticorps

• 1110013J05Rik anticorps
• BCCIP anticorps
• DKFZp459K2416 anticorps
• MGC82792 anticorps
• MGC89311 anticorps
• Afficher tous les alias de synonymes
• mp:zf637-1-000774 anticorps
• TOK-1 anticorps
• TOK1 anticorps
• zgc:110272 anticorps

Protein level used designations for BCCIP

BRCA2 and CDKN1A interacting protein , protein BCCIP homolog , BRCA2 and CDKN1A-interacting protein , bccip-like , BCCIPalpha , BCCIPbeta , BRCA2 and Cip1/p21 interacting protein , TOK-1alpha , TOK-1beta , cdk inhibitor p21 binding protein , p21- and CDK-associated protein 1 , protein TOK-1