Hes Family bHLH Transcription Factor 1 Protéines (HES1)

This protein belongs to the basic helix-loop-helix family of transcription factors. De plus, nous expédions HES1 Anticorps (154) et HES1 Kits (15) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
HES1 3280 Q14469
HES1 15205 P35428
HES1 29577 Q04666
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Top HES1 Protéines sur anticorps-enligne.fr

Showing 10 out of 15 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
Détails
Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
$338.33
Détails
Escherichia coli (E. coli) Humain His tag Validation with Western Blot 50 μg Connectez-vous pour afficher 11 Days
$291.50
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
$888.80
Détails
Levure Xenopus laevis His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,693.17
Détails
Levure Boeuf (Vache) His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,735.33
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,737.17
Détails
Levure Poulet His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,764.67
Détails
Escherichia coli (E. coli) Humain His tag   10 μg Connectez-vous pour afficher 5 to 8 Days
$473.19
Détails

HES1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Plus protéines pour Hes Family bHLH Transcription Factor 1 (HES1) partenaires d'interaction

Human Hes Family bHLH Transcription Factor 1 (HES1) interaction partners

  1. We defined the KK-LC-1/presenilin-1/Notch1/Hes1 as a novel signalling pathway that was involved in the growth and metastasis of hepatocellular carcinoma.

  2. High HES1 expression is associated with invasiveness and tumorigenicity of non-small cell lung cancer.

  3. High expression of Hes1 is associated with Colorectal Cancer.

  4. High HES1 expression is associated with pancreatic neoplasms.

  5. Depletion of HES1 increased cell death in response to endoplasmic reticulum stress in mouse and human cells, in a manner that depended on the pro-apoptotic gene growth arrest and DNA damage-inducible protein GADD34.

  6. The Sox17-Notch1-Hes1 pathway is critical for maintaining the undifferentiated state of IAHCs.

  7. MiR-182 alleviates the development of cyanotic congenital heart disease by suppressing HES1

  8. The results of this study demonstrate that HES1 is a specific downstream gene of NOTCH1 and that it contributes to SACC proliferation, apoptosis and metastasis.

  9. HES1 is mono-ubiquitinated in a Fanconi anemia core complex-dependent manner.

  10. Hes-1 knockdown promotes osteopontin expression in HUVECs and enhances OPN-induced angiogenesis.

  11. Our results suggest that KN promotes goblet cell differentiation by regulating Wnt, Notch, and AhR signals and expression of Hes1 and Hath1.

  12. In the present study, the authors reported the first observation of Hes1 oscillatory expression in human neural progenitor /stem cells, with an approximately 1.5 hour periodicity and a Hes1 protein half-life of about 17 (17.6 +/- 0.2) minutes. Human cytomegalovirus infection disrupts the Hes1 rhythm and down-regulates its expression.

  13. A three-molecule score based on the expression of Notch pathway molecules: Jagged1, intracellular Notch1 (ICN1) and Hes1 (JIH score) to assess prognostic value in non-metastasis clear cell renal cell carcinoma (ccRCC).

  14. we demonstrate for the first time an essential role of HPV oncoprotein E6 that selectively overexpresses in CaCxSLCs and participates in maintenance of stem cell phenotype and stemness through upregulation of Hes1 while preponderance of E7 leads to differentiation.

  15. IE1 is involved in Hes1 degradation by assembling a ubiquitination complex and promoting Hes1 ubiquitination as a potential E3 ubiquitin ligase, followed by proteasomal degradation of Hes1.

  16. Notch signaling and Id2/3 regulate neurogenesis in a complementary manner and ID factors can induce neural stem cell maintenance and quiescence in the absence of Notch.

  17. The phenotype was rescued by ectopic expression of miRNA182-5p in Delta182 cells. A bioinformatic analysis and Hes1 modulation data suggested that Hes1 could be a putative target of miRNA182-5p. A reciprocal relationship between miRNA182-5p and Hes1 was seen in the context of TK inhibition

  18. These results suggest that HES1 promotes extracellular matrix protein expression and inhibits proliferative and migratory functions in the trabecular meshwork cells under oxidative stress, thereby providing a novel pathogenic mechanism underlying and a potential therapeutic target to primary open-angle glaucoma

  19. Hes1 disruption leads to tumor regression without perturbing normal stem cell homeostasis, preclinically validating Hes1 as a cancer therapeutic target.

  20. Low Hes1 expression is associated with left ventricle hypertrabeculation/non-compaction and Menetrier-like gastropathy.

Mouse (Murine) Hes Family bHLH Transcription Factor 1 (HES1) interaction partners

  1. Ablation of the Hes1 oscillator in stem cells interfered with stable MyoD oscillations and led to prolonged periods of sustained MyoD expression, resulting in increased differentiation propensity

  2. Ascl1 oscillations, which normally depend on Hes1 oscillations, regulate the active state, while high Hes1 expression and resultant Ascl1 suppression promote quiescence in neural stem cells.

  3. Findings indicate that nuclear translocation of MSX-1, alone or in combination with HES-1, produce chondrocyte-like cells, and simultaneous activation of HES-1 and MSX-1 increases the generation of smooth muscle and neuronal cells.

  4. Olig2 represses expression of the Notch signaling pathway effectors Hes1 and Hes5

  5. Depletion of HES1 increased cell death in response to endoplasmic reticulum stress in mouse and human cells, in a manner that depended on the pro-apoptotic gene growth arrest and DNA damage-inducible protein GADD34.

  6. this paper shows that epithelial Hes1 maintains gut homeostasis by preventing microbial dysbiosis

  7. miR-374b regulates the proliferation and differentiation of neural stem cells through targeting Hes1. Overexpression of Hes1 reverses the effect of miR-374b overexpression on neural stem cells differentiation.

  8. Hes1 might contribute to the maturation and the cellular structure organization of biliary epithelial cells, which provides new insight into understanding the pathology of biliary atresia.

  9. the results raise the possibility that HES1 or other genes that affect HES1 expression could be involved in the etiology of Ectopic pancreas .

  10. These results suggest that hyperhomocysteinemia-enhanced brain damage is associated with increased autophagy and neuronal apoptosis in Apo E(-/-) mice, in which downregulation of hes1 and hes5 is involved.

  11. Although Hes5-GFP and Hes1 are coexpressed in particular developmental contexts, we also noted cohorts of lens or retinal cells expressing just one factor. The dynamic Hes5-GFP expression pattern, coupled with its derepressed expression in Hes1 mutants, suggests that this transgene contains the relevant cis-regulatory elements that regulate endogenous Hes5 in the mouse lens and retina.

  12. there is a link between Dmrta2 modulation of Hes1 expression and the maintenance of neural progenitor cells during cortical development

  13. Hes-1 expression is maintained in neural progenitor territory throughout mouse neocortical development, a simple shift from Notch-independent to -dependent state makes it pleiotropic as the former maintains the neural stem cells in a non-dividing/slow-dividing state, whereas the latter is very much required for maintenance and proliferation of radial glial cells.

  14. inhibition of PTEN by Notch1/Hes1 in response to high glucose concentration inhibits autophagy, which is associated with the progression of fibrosis in diabetic nephropathy

  15. this paper shows the critical role of the Notch1-Hes1 signaling cascade in the regulation of innate immunity in acetaminophen-triggered liver inflammation

  16. results suggest that SCF(FBXL14) promotes neuronal differentiation by targeting HES1 for ubiquitin-dependent proteolysis and that the C-terminal WRPW motif in HES1 is required for this process

  17. Notch signaling and Id2/3 regulate neurogenesis in a complementary manner and ID factors can induce neural stem cell maintenance and quiescence in the absence of Notch.

  18. that HIF-1alpha but not HIF-2alpha is able to interact with either GA-binding protein alpha or GA-binding protein beta1

  19. Hes1 disruption leads to tumor regression without perturbing normal stem cell homeostasis, preclinically validating Hes1 as a cancer therapeutic target.

  20. Notch1-Hes-1 signaling controls TLR7-induced autophagic death of macrophage via regulation of P62 in mice with lupus.

Pig (Porcine) Hes Family bHLH Transcription Factor 1 (HES1) interaction partners

  1. study identified nucleolar complex protein 3 homolog(FAD24) as a novel downstream target of transcription factor HES1 during adipogenesis

Profil protéine HES1

Profil protéine

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.

Gene names and symbols associated with HES1

  • hes family bHLH transcription factor 1 (HES1)
  • hairy and enhancer of split 1 (Drosophila) (Hes1)
  • hes family bHLH transcription factor 1 (Hes1)
  • hes family bHLH transcription factor 4 (HES4)
  • hes family bHLH transcription factor 1 L homeolog (hes1.L)
  • bHLHb39 Protéine
  • c-hairy1A Protéine
  • HAIRY1 Protéine
  • HES-1 Protéine
  • hes1 Protéine
  • HHL Protéine
  • Hry Protéine
  • Xhairy-1 Protéine
  • Xhairy1 Protéine
  • Xlh1 Protéine

Protein level used designations for HES1

class B basic helix-loop-helix protein 39 , hairy homolog , hairy-like protein , transcription factor HES-1 , RHL , C-HAIRY1 , c-hairy1B , Hairy and enhancer of split 1-A , Protein hairy-1 , hairy1 , transcription factor HES-1-A , hairy and enhancer of split 1 , LOW QUALITY PROTEIN: transcription factor HES-1

GENE ID SPECIES
3280 Homo sapiens
539547 Bos taurus
15205 Mus musculus
29577 Rattus norvegicus
395128 Gallus gallus
100499567 Sus scrofa
397813 Xenopus laevis
100734567 Cavia porcellus
101106560 Ovis aries musimon
Fournisseurs de qualité sélectionnés pour HES1 Protéines (HES1)
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