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LHX1 encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain.
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Human Monoclonal LHX1 Primary Antibody pour FACS, ICC - ABIN4330988
Xia, Nivet, Sancho-Martinez, Gallegos, Suzuki, Okamura, Wu, Dubova, Esteban, Montserrat, Campistol, Izpisua Belmonte: Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells. dans Nature cell biology 2013
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Cow (Bovine) Polyclonal LHX1 Primary Antibody pour WB - ABIN2779598
Phillips: Assignment of LHX1 to human chromosome bands 17q11.2-->q12 by use of radiation hybrid mapping and somatic cell hybridization. dans Cytogenetic and genome research 2002
Report novel missense mutation in LHX1 in congenital absence of the uterus and vagina which could change the transcriptional activity of LHX1 and its effect on the regulation of the downstream target gene GSC (Montrer GSC Anticorps).
Our MRKH families included 43 quads, 26 trios, and 30 duos. Of our MRKH probands, 87/147 (59%) had MRKH type 1 and 60/147 (41%) had type 2 with additional anomalies. CONCLUSION(S): Although the prevalence of WNT4 (Montrer WNT4 Anticorps), HNF1B (Montrer HNF1B Anticorps), and LHX1 point mutations is low in people with MRKH, the prevalence of CNVs was approximately 19%.
Data have identified TBX6 (Montrer TBX6 Anticorps) as a new gene associated with Mullerian aplasia. The results also support the relevance of LHX1 and CNVs in the development of this congenital malformation.
study concludes that heterozygous mutations of LHX1 might be one cause of the Mayer-Rokitansky-Kuster-Hauser syndrome in a subgroup of patients
Data indicate that expression of ERAS, LHX1, and CCRK (Montrer CDK20 Anticorps) is increased in aggressive subgroups of medulloblastomas.
Lim1/LIM1 expression in neonatal, adult mouse and human endometrium suggesting Lim1/LIM1 may have a role in endometrial development and remodelling
Mutations in the coding regions of LHX1 may not be a common genetic etiologic factor involved in Han Chinese patients with mullerian duct abnormalities.
Eleven dysplastic kidneys showed no expression of LIM1. In contrast, 12 of 32 nephroblastomas showed nuclear positivity.
findings establish that the developmental marker Lim1 acts as an oncogene (Montrer RAB1A Anticorps) in cancer cells and targeting Lim1 may constitute an innovative therapeutic intervention in human lear cell carcinoma
Lim1 (also known as Lhx1) gene consists of a DNA-binding homeodomain and 2 cysteine-rich LIM (Montrer PDLIM5 Anticorps) domains, which may participate in protein to protein interactions, and encodes a transcription factor.
Smad4 (Montrer SMAD4 Anticorps)/Eomes (Montrer EOMES Anticorps)-dependent Lhx1 expression in the epiblast marks the entire definitive endoderm lineage, the anterior mesendoderm, and midline progenitors.
LHX1 is required in the anterior mesendoderm, but not in the mesoderm, for formation of the head.
Lhx1 maintains synchrony among circadian oscillator neurons of the suprachiasmatic nucleus.
Lhx1 is necessary for SCN (Montrer SRI Anticorps) terminal differentiation, including expression of neuropeptides profoundly important for circadian function.
OTX2 (Montrer OTX2 Anticorps) has a role in regulating Dkk1 (Montrer DKK1 Anticorps) and Lhx1 activity in the anterior mesendoderm
These studies identify LHX1 as the first transcription factor that is essential in the Mullerian duct epithelial progenitor cells for female reproductive tract development.
a core regulatory subcircuit composed of Pax2 (Montrer PAX2 Anticorps)/8, Gata3 (Montrer GATA3 Anticorps) and Lim1 turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization.
Lhx1 therefore may influence the localization of primordial germ cells by modulating Ifitm1 (Montrer IFITM1 Anticorps)-mediated repulsive activity.
The response of LMC motor neurons to Reelin (Montrer RELN Anticorps) is gated by Foxp1 (Montrer FOXP1 Anticorps)- and Lhx1-mediated regulation of expression of the critical Reelin (Montrer RELN Anticorps) signalling intermediate Dab1 (Montrer DAB1 Anticorps).
Inactivation of either PINCH (Montrer LIMS1 Anticorps) isoform independently leads to instability of ILK (Montrer ILK Anticorps), loss of stretch-responsive anf (Montrer HESX1 Anticorps) and vegf (Montrer VEGFA Anticorps) expression, and progressive heart failure
These results demonstrate an essential role for Lhx1 in driving specification of the entire kidney field from the intermediate mesoderm.
nephrogenic transcription factors (osr1 (Montrer OSR1 Anticorps), osr2, hnf1b (Montrer HNF1B Anticorps), lhx1, pax8 (Montrer PAX8 Anticorps))play important role in nephrogenesis but have no pronephros induction potential upon overexpression; they activate transcription cascades reflecting activation by activin A (Montrer INHBA Anticorps), retinoic acid
Substantial evidence is found for a prosomeric organization of the diencephalon based on alternating expression of Lhx1/5 and Lhx2 (Montrer LHX2 Anticorps)/9 genes during larval development and in the adult.
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and urogenital systems. This gene is a candidate for Mayer-Rokitansky-Kuster-Hauser syndrome, a disorder characterized by anomalies in the female genital tract.
LIM homeobox protein 1
, LIM/homeobox protein Lhx1
, homeobox protein Lim-1
, LIM homeo box protein 1
, domesticus (clone 2.3 kB) lim-1
, Homeobox protein LMX-2
, Homeobox protein Lim-1