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LHX6 encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain.
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studies identify Lhx6-positive GABAergic neurons in the ventral zona incerta that promote sleep
LHX6 inhibits breast cancer cell proliferation and invasion via repression of the Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signaling pathway.
Lhx6 and Lhx8 (Montrer LHX8 Anticorps) promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2 (Montrer CDKN1C Anticorps)
Studies indicate that LIM (Montrer PDLIM5 Anticorps) homeobox (Montrer PRRX1 Anticorps) proteins Lhx6 and -8 mRNAs are primarily expressed in the ventral telencephalon, specifically in the medial ganglionic eminence (MGE) of the basal forebrain and in subsets of neurons in the striatum.
The data of this study showed the molecular identity of Lhx6 mutants and introduce technologies to test mechanisms in GABAergic interneuron differentiation.
Lhx6 plays an important role in the maturation of cortical interneurons and the formation of inhibitory circuits in the mammalian cortex
Msx1 (Montrer MSX1 Anticorps) interacts with Lhx6 and Sna (Montrer SNAI1 Anticorps) in vivo. A network of transcription factors operates during early tooth morphogenesis.
LHX6 is a transcriptional repressor that interacts with pituitary homeobox 2 (PITX2 (Montrer PITX2 Anticorps)) to regulate odontogenesis
Lhx6 and Lhx8 (Montrer LHX8 Anticorps) coordinately induce neuronal expression of Shh (Montrer SHH Anticorps) that controls the generation of interneuron progenitors.
Lhx6 functions may be partially redundant in the mesenchyme of the secondary palate, but not in the palatal epithelium.
LHX6 is a putative tumour suppressor gene with epigenetic silencing in lung cancer.
found positive association of LHX6 with Tourette syndrome in some European populations, not others. LHX6 demonstrates a high degree of population differentiation and is correlated with the North to South axis of European genetic variation.
Hypermethylation of LHX6 is associated with cervical cancer.
differentially methylated hypermethylation of LHX6 is a good cancer marker in HNSCC as well as in other kinds of neoplasias and confirm the importance of searching for markers of epigenetic dysregulation in cancer
This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.
LIM-homeodomain protein 6.1
, LIM/homeobox protein Lhx6
, LIM/homeobox protein Lhx6.1
, LIM homeodomain protein 6.1
, LIM homeobox protein 6
, LIM homeobox 6
, LIM homeodomain transcription factor, N terminal-like
, putative LIM homeodomain transcription factor, N terminal
, LIM homeodomain protein
, LIM/homeobox protein Lhx6-like