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MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2\; MIM 608507) and DRP1 (DNM1L\; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008].. De plus, nous expédions MARCH5 Protéines (4) et beaucoup plus de produits pour cette protéine.
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Cow (Bovine) Polyclonal MARCH5 Primary Antibody pour WB - ABIN2774746
Karbowski, Neutzner, Youle: The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. dans The Journal of cell biology 2007
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MARCH5 gene is duplicated in rainbow trout, but only fish-specific gene copy is up-regulated after Viral hemorrhagic septicemia virus infection.
the results of this study identified MARCH5 as a candidate oncogene (Montrer RAB1A Anticorps) in ovarian cancer and a potential target for ovarian cancer therapy.
MARCH5 directly interacts with FUNDC1 (Montrer FUNDC1 Anticorps) to mediate its ubiquitylation at lysine 119 for subsequent degradation.
These findings and data showing MARCH5-dependent degradation of MiD49 (Montrer SMCR7 Anticorps) upon stress support the possibility that MARCH5 regulation of MiD49 (Montrer SMCR7 Anticorps) is a novel mechanism controlling mitochondrial fission and, consequently, the cellular response to stress.
Self-clearance mechanism of mitochondrial ligase MARCH5 contributes to mitochondria quality control.MARCH5 is regulated by auto-ubiquitination.
MARCH5 binds MAVS (Montrer MAVS Anticorps) only during viral stimulation when MAVS (Montrer MAVS Anticorps) forms aggregates, and these interactions require the RING domain of MARCH5 and the CARD domain of MAVS (Montrer MAVS Anticorps).
Our results indicate that HDAC6 (Montrer HDAC6 Anticorps) is a critical regulator of MFN2 (Montrer MFN2 Anticorps) degradation by MARCH5, thus protecting mitochondrial connectivity from hypoxic stress.
A fine balance of Mfn1 (Montrer MFN1 Anticorps) levels is maintained by MARCH5-mediated quality control on acetylated Mfn1 (Montrer MFN1 Anticorps).
MITOL regulates ER tethering to mitochondria by activating Mfn2 (Montrer MFN2 Anticorps) via K192 ubiquitination.
balance between LC1 (Montrer MAP1B Anticorps) activation by S-nitrosylation and down-regulation by MITOL is critical for neuronal cell survival
MARCH5 is an authentic E3 ubiquitin ligase (Montrer MUL1 Anticorps) and catalyzes K63-linked polyubiquitination of TANK. MARCH5 modulates TLR7 (Montrer TLR7 Anticorps) signaling via releasing the inhibitory action of TANK toward TRAF6 (Montrer TRAF6 Anticorps).
These findings suggest that MITOL plays a protective role against apoptosis in cardiomyocytes.
March5 is involved in maintaining mouse-ESC (mESC) pluripotency via catalysis of Prkar1a (Montrer PRKAR1A Anticorps) polyubiquitination and inhibition of the Raf (Montrer RAF1 Anticorps)/MEK (Montrer MDK Anticorps)/ERK (Montrer EPHB2 Anticorps) pathway.
Results indicate that MITOL plays a protective role against mitochondrial dysfunction caused by the mitochondrial accumulation of mSOD1 via the ubiquitin-proteasome pathway.
MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2\; MIM 608507) and DRP1 (DNM1L\; MIM 603850) (Nakamura et al., 2006
membrane-associated ring finger (C3HC4) 5
, E3 ubiquitin-protein ligase MARCH5
, membrane-associated RING finger protein 5
, membrane-associated RING-CH protein V
, mitochondrial ubiquitin ligase
, ring finger protein 153