anti-Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12) Anticorps

Exhibits an oxidoreductive catalytic activity towards retinoids. De plus, nous expédions RDH12 Protéines (8) et et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
RDH12 77974 Q8BYK4
RDH12 145226 Q96NR8
RDH12 314264  
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Top anti-RDH12 Anticorps sur anticorps-enligne.fr

Showing 10 out of 21 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-RDH12 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human Intestine 100 μL 2 to 3 Days
$289.00
Détails
Chien Lapin Inconjugué WB WB Suggested Anti-RDH12 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Transfected 293T 100 μL 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué WB 100 μL 11 to 14 Days
$551.83
Détails
Boeuf (Vache) Lapin Inconjugué WB 100 μL 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué ELISA, WB 100 μL 2 to 3 Days
$446.88
Détails
Humain Souris Inconjugué IF, ELISA, WB Detection limit for recombinant GST tagged RDH12 is 0.3 ng/ml as a capture antibody. Immunofluorescence of monoclonal antibody to RDH12 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg 11 to 12 Days
$440.00
Détails
Humain Lapin Inconjugué WB Western Blot analysis of RDH12 expression in transfected 293T cell line by RDH12 MaxPab polyclonal antibody.Lane 1: RDH12 transfected lysate(35.10 KDa).Lane 2: Non-transfected lysate. 100 μg 11 to 12 Days
$425.71
Détails
Humain Souris Inconjugué WB Western Blot analysis of RDH12 expression in transfected 293T cell line by RDH12 MaxPab polyclonal antibody.Lane 1: RDH12 transfected lysate(34.76 KDa).Lane 2: Non-transfected lysate. 50 μg 11 to 12 Days
$440.00
Détails
Humain Lapin Inconjugué WB RDH12 antibody used at 1 ug/ml to detect target protein. 50 μg 9 to 11 Days
$449.29
Détails
Humain Lapin Biotin ELISA   100 μg 11 to 18 Days
$469.05
Détails

anti-RDH12 Anticorps mieux référencés

  1. Dog (Canine) Polyclonal RDH12 Primary Antibody pour WB - ABIN2785175 : Sun, Gerth, Maeda, Lodowski, Van Der Kraak, Saperstein, Héon, Palczewski: Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations. dans Vision research 2007 (PubMed)

Plus d’anticorps contre RDH12 partenaires d’interaction

Mouse (Murine) Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12) interaction partners

  1. RDH12 in inner segments can protect vital cell organelles against aldehyde toxicity caused by an intracellular leak of all-trans-retinal, as well as other aldehydes originating both inside and outside the cell.

  2. RDH12 plays a unique, nonredundant role in the photoreceptor inner segments to regulate the flow of retinoids in the eye.

  3. The present findings, together with those of earlier studies showing only minor functional deficits in mice deficient for Rdh5, Rdh8, or Rdh11, suggest that the activity of any one isoform is not rate limiting in the visual response.

  4. Oxidative stress induced by exposure to constant bright light led to a rapid and significant decrease of RDH12 protein. The low and constant expression of RDH11 suggested a housekeeping function for this enzyme.

  5. a critical function of RDH12 is the reduction of all-trans-retinal that exceeds the reductive capacity of the photoreceptor outer segments

Human Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12) interaction partners

  1. RDH12-IRD causes an early-onset, retina-wide disease with particularly severe central retinal abnormalities associated with relatively less severe rod photoreceptor dysfunction, a pattern consistent with an early-onset cone-rod dystrophy.

  2. The RDH12 compound heterozygous variants might be the cause of the LCA family. Our study adds to the molecular spectrum of RDH12-related retinopathy and offers an effective example of the power of phenotype-genotype correlations in molecular diagnosis of LCA.

  3. Peripapillary sparing is a novel phenotypic feature of RDH12-associated Leber congenital amaurosis.

  4. The mutation detection of RDH12 in this study also implies that whole exome sequencing is a useful method for detection of potential mutations in small families with atypical clinical manifestations of genetic disease.

  5. We report 4 children from 3 consanguineous families with bilateral elevation deficiency in the context of retinal dystrophy. All were found to harbor recessive mutations in retinal dehydrogenase 12 (RDH12).

  6. Mutations in the AIPL1 and RDH12 genes associated with leber congenital amaurosis in two Turkish families.

  7. Here we demonstrate that microtubule-associated protein 1 light chain 3A (LC3A), a marker of autophagy, is related to hypoxia and poor prognosis in clear cell ovarian cancer.

  8. The three patients with Leber congenital amaurosis/early-onset retinal dystrophy had a progressive decrease of their vision with the formation of a posterior staphyloma.

  9. Two novel missense mutations in the RDH12 gene are associated with retinitis pigmentosa.

  10. Seventeen novel mutations in the RDH12 gene were identified that accounted for approximately 7% of disease in a cohort of patients diagnosed with Leber congenital amaurosis and early-onset retinal dystrophy.

  11. LCA has been associated with sequence variations of 14 different genes; in approximately 30% of all cases pathogenic mutations remain to be determined.

  12. The retina RDH12 reduces 4-HNE to a nontoxic alcohol, protecting cellular macromolecules against oxidative modification and protecting photoreceptors from light-induced apoptosis.

  13. Results suggest that the accelerated degradation of RDH12 mutants by the ubiquitin-proteasome system contributes to the pathophysiology and phenotypic variability associated with mutations in the RDH12 gene.

  14. Our studies show that RDH12 is associated with retinal dystrophy and encodes an enzyme with a unique, nonredundant role in the photoreceptor cells.

  15. All patients harboring RDH12 mutations had a severe yet progressive rod-cone dystrophy with severe macular atrophy but no or mild hyperopia.

  16. In most tissues RDH12 primarily contributes to the reduction of all-trans-retinaldehyde; however, in cells undergoing oxidative stress, such as photoreceptors, RDH12 might also play a role in detoxification of lipid peroxidation products.

  17. The results demand critical consideration of the human disease mechanism and the therapeutic approach in patients with mutations in the putative visual cycle gene RDH12.

  18. Ophthalmic findings in persons with RDH12 mutations suggest that RDH12 loss-of-function results in a characteristic form of early and progressive rod-cone degeneration

  19. Human type 12 RDH reduces dihydrotestosterone to androstanediol, and is thus involved in steroid metabolism.

  20. in patients with Leber congenital amaurosis, autosomal recessive retinitis pigmentosa, and autosomal dominant/recessive cone-rod dystrophies six different variants of RDH12 were observed of which three variants were novel

RDH12 profil antigène

Profil protéine

Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments (By similarity).

Gene names and symbols associated with RDH12

  • retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (RDH12) anticorps
  • retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (rdh12) anticorps
  • retinol dehydrogenase 12 (MAV_1968) anticorps
  • retinol dehydrogenase 12 (CC1G_02720) anticorps
  • Retinol dehydrogenase 12 (Bm1_36660) anticorps
  • retinol dehydrogenase 12 (PTRG_03574) anticorps
  • retinol dehydrogenase 12 (PTRG_05326) anticorps
  • retinol dehydrogenase 12 (PTRG_08067) anticorps
  • retinol dehydrogenase 12 (LOC100282710) anticorps
  • retinol dehydrogenase 12 (LOC100285880) anticorps
  • retinol dehydrogenase 12 (LOC100226769) anticorps
  • retinol dehydrogenase 12 (Rdh12) anticorps
  • retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (Rdh12) anticorps
  • A930033N07Rik anticorps
  • DSSDR2 anticorps
  • LCA3 anticorps
  • LCA13 anticorps
  • RP53 anticorps
  • SDR7C2 anticorps
  • wu:fj43a10 anticorps
  • zgc:92430 anticorps

Protein level used designations for RDH12

retinol dehydrogenase 12 (all-trans and 9-cis) , retinol dehydrogenase 12 , Retinol dehydrogenase 12 , retinol dehydrogenase 12 (all-trans/9-cis/11-cis) , all-trans and 9-cis retinol dehydrogenase , retinol dehydrogenase 12, all-trans and 9-cis , short chain dehydrogenase/reductase family 7C, member 2 , double substrate specificity short chain dehydrogenase/reductase 2 , double substrate specificity short-chain dehydrogenase/reductase 2 , double substrate-specificity short chain dehydrogenase/reductase 2

GENE ID SPECIES
423274 Gallus gallus
436597 Danio rerio
4528332 Mycobacterium avium 104
6016890 Coprinopsis cinerea okayama7130
6102217 Brugia malayi
6341805 Pyrenophora tritici-repentis Pt-1C-BFP
6343577 Pyrenophora tritici-repentis Pt-1C-BFP
6346345 Pyrenophora tritici-repentis Pt-1C-BFP
100282710 Zea mays
100285880 Zea mays
490744 Canis lupus familiaris
711438 Macaca mulatta
100226769 Taeniopygia guttata
77974 Mus musculus
145226 Homo sapiens
314264 Rattus norvegicus
369021 Bos taurus
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