anti-Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 (SERPINC1) Anticorps

The protein encoded by SERPINC1 is a plasma protease inhibitor and a member of the serpin superfamily. De plus, nous expédions Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 Kits (74) et Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 Protéines (38) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SERPINC1 462 P01008
SERPINC1 11905 P32261
SERPINC1 304917  
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Top anti-Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 319 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB WB Suggested Anti-SERPINC1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  PANC1 cell lysate Immunohistochemistry with Liver tissue at an antibody concentration of 5µg/ml using anti-SERPINC1 antibody (ARP41402_P050) 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-Serpinc1 Antibody   Titration: 1.0 ug/ml   Positive Control: Mouse Small Intestine 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué WB Western blot analysis of Antithrombin III expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Chien Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué WB Western blot with human antithrombin III antibody: Lane 1: rat kidney lysate - 60 µg Lane 2: mouse muscle lysate- 66 µg Lane 3: human serum - 5.2 µg Lane 4: Human antithrombin III -2 ng Lane 5: Human antithrombin III - 10 ng Lane 6: Human antithrombin III - 50 ng 100 μg Connectez-vous pour afficher 2 to 3 Days
$265.00
Détails
Roussette (Chauve-souris) Lapin Inconjugué IHC, IHC (p), WB Anti-Antithrombin III antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN958322 concentration 5 ug/ml. Anti-Antithrombin III antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. ... 50 μg Connectez-vous pour afficher 11 to 14 Days
$727.83
Détails
Humain Lapin Inconjugué FACS, IF, IHC (p), WB Western blot analysis of SERPINC1 Antibody (C-term) (ABIN390671) in mouse liver tissue lysates (35 µg/lane). SERPINC1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with SERPINC1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Connectez-vous pour afficher 10 to 11 Days
$385.00
Détails
Humain Lapin Inconjugué EIA, WB   0.4 mL Connectez-vous pour afficher 4 to 8 Days
$522.50
Détails
Cat Mouton Inconjugué ID, IEP, IHC, IHC (p) Human Intestine, Vessel: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-Antithrombin III antibody IHC of human intestine, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μL Connectez-vous pour afficher 11 to 14 Days
$484.00
Détails
Humain Lapin Inconjugué ELISA, IHC, WB Western blot analysis of Mouse liver tissue lysates, using SERPINC1 Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276733 at 1/100 staining Human melanoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Connectez-vous pour afficher 11 to 12 Days
$390.77
Détails

anti-Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 Anticorps mieux référencés

  1. Dog (Canine) Polyclonal SERPINC1 Primary Antibody pour WB - ABIN610759 : Cool, Normant, Shen, Chen, Pannell, Zhang, Loh: Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice. dans Cell 1997 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal SERPINC1 Primary Antibody pour IHC, IHC (p) - ABIN4352910 : Kuusisto, Haapasaari, Remes, Bloigu, Karihtala, Turpeenniemi-Hujanen, Kuittinen: Antithrombin III is probably not a suitable biomarker for diagnosis of primary central nervous system lymphoma. dans Annals of hematology 2015 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal SERPINC1 Primary Antibody pour IHC (p), IHC - ABIN449427 : Wang, Zhang, Sze, van de Weg, Vernooij, Schoneveld, Tan, Versteeg, Timmers, Lam, de Kleijn: Lowering Low-Density Lipoprotein Particles in Plasma Using Dextran Sulphate Co-Precipitates Procoagulant Extracellular Vesicles. dans International journal of molecular sciences 2018 (PubMed)

  4. Human Monoclonal SERPINC1 Primary Antibody pour ELISA, WB - ABIN532623 : Saito, Minamiya, Kalina, Saito, Ogawa: Effect of antithrombin III on neutrophil deformability. dans Journal of leukocyte biology 2005 (PubMed)

Plus d’anticorps contre Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 partenaires d’interaction

Human Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 (SERPINC1) interaction partners

  1. This study results indicate a difference between type I and type II antithrombin (AT) deficiency. The risk of pregnancy related venous thromboembolism was equally present in both groups, except for AT Budapest 3 in the heterozygous variant, while adverse pregnancy outcomes were strictly related to type II, especially AT Budapest 3 in the homozygous variant.

  2. The frequency of SERPINC1, PROC, and PROS1 mutations and their thromboembolic manifestations was characterized in patients with AT, PC, or PS deficiencies, inhabiting southern Poland.

  3. Molecular analysis may be the best method to identify antithrombin deficiency. Up to 80% of patients with antithrombin deficiency have SERPINC1 gene defects, mostly (90% of the 315 gene defects described so far) point mutations or small deletions or insertions affecting the 7 exons or flanking regions. [review]

  4. Laboratory tests and direct sequencing of PROC and SERPINC1 were conducted for the patient and his family members. Coagulation tests revealed that the patient presented type I antithrombin deficiency combined with decreased protein C activity resulting from a small insertion mutation c.848_849insGATGT in SERPINC1 and a short deletion variant c.572_574delAGA in PROC.

  5. Thirty-one members of a single family were included. Clinical data was collected regarding thrombotic history. The mutation was identified by direct sequencing of the SERPINC1 gene. HEK293 cells were transfected with wild type and mutant SERPINC1 plasmids.

  6. the first report of regulatory region polymorphisms in SERPINC1 gene in Indian population

  7. this study shows that risk for thrombosis is associated with the different SERPINC1 genotypes

  8. Report high levels of latent antithrombin in plasma from patients with antithrombin deficiency caused by mutations affecting the stability of the native conformation.

  9. Study identified one new small deletion within AT, which results in the loss of four amino acids (INEL) and is located at strand 3 of beta-sheet A, a region highly conserved in SERPINC1. This mutation leads to type I AT deficiency by promoting the intracellular retention of AT, which induces ER stress.

  10. It was our aim to identify mutations in SERPINC1 causing transient antithrombin deficiency. SERPINC1 was sequenced in 214 cases with a positive test for antithrombin deficiency, including 67 with no deficiency in the sample delivered to our laboratory. The p.Val30Glu mutation (Antithrombin Dublin) was identified in five out of these 67 cases, as well as in three out of 127 cases with other SERPINC1 mutations.

  11. different types of SERPINC1 mutations may play different roles in the development of VTE

  12. aberrant N-glycosylation causing a recessive or transient antithrombin deficiency is a new form of thrombophilia that does not have a SERPINC1 gene defect

  13. evaluation of serum proteins reveals that SERPINA1, SERPINA3 and SERPINC1 could be useful to discriminate healthy from colorectal carcinoma patients with a high sensitivity and specificity

  14. The results this study reveal several novel mutations to the already growing list of SERPINC1 mutations, thereby adding to our knowledge of the molecular background of antithrombin deficiency.

  15. Data indicate that all patients suffered from homozygous antithrombin (AT) deficiency caused by the mutation p.Leu131Phe in the AT gene (SERPINC1).

  16. Studies indicate that antithrombin III (ATIII) and its gene SerpinC1 may be related to many diseases, including hypertension and kidney diseases.

  17. The odds ratio of developing idiopathic fatal pulmonary embolism as a variant carrier for SERPINC1 is 144.2 (95% CI, 26.3-779.4; P = 1.7 x 10- 7).

  18. Nine patients (1.8%), [5% in arterial thrombosis and 0.8% in venous thrombosis] showed a missense variant in exon 5 i.e. p.Pro305His (c.1033 C > A); none of these patients showed the presence of any other variations in the gene.

  19. In Hungary, the founder mutation, ATBp3, is the most common Antithrombin deficiency

  20. Our studies of ATIII in-cell folding reveal a surprising, biased order of disulfide bond formation, with early formation of the C-terminal disulfide, before formation of the N-terminal disulfides, critical for folding to the active, metastable state

Mouse (Murine) Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 (SERPINC1) interaction partners

  1. Trancriptomic analysis shows that expression of the antithrombins serpin C1 and D1 is significantly reduced in Schwann cell-deficient mice. In the absence of peripheral neuromuscular activity, neurodegeneration is completely blocked, and expression of prothrombin in muscle is markedly reduced.

  2. RNA interference of Serpinc1 and/or Proc allows for evaluation of the function of these genes in vivo and provides a novel, controlled mouse model for spontaneous venous thrombosis.

  3. Mice homozygous for the heparin-binding domain mutation R48C developed spontaneous, life-threatening thrombosis, occurring as early as the day of birth. Only 60% of the offspring reached weaning age, with further loss at different ages

  4. in the heart, TF plays an important role in the thrombogenesis and it counterbalances AT-dependent anticoagulation; regulation of TF-procoagulant activity take place differently between the liver and the heart

Cow (Bovine) Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 (SERPINC1) interaction partners

  1. ATIII may be protective in HIV-1 disease by inhibiting HIV-1 replication

Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 (SERPINC1) profil antigène

Profil protéine

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.

Gene names and symbols associated with SERPINC1

  • serpin family C member 1 (SERPINC1) anticorps
  • antithrombin-III (CpipJ_CPIJ000472) anticorps
  • antithrombin-III (CpipJ_CPIJ013111) anticorps
  • serpin family C member 1 (Serpinc1) anticorps
  • serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 (Serpinc1) anticorps
  • AI114908 anticorps
  • ANTITHROMBIN, AT-III anticorps
  • At-3 anticorps
  • AT-III anticorps
  • At3 anticorps
  • AT3D anticorps
  • ATIII anticorps
  • DKFZp470C1733 anticorps
  • SERPINC1 anticorps
  • THPH7 anticorps

Protein level used designations for SERPINC1

antithrombin-III , serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 , serpin peptidase inhibitor, clade C (antithrombin), member 1 , Antithrombin-III , anti-thrombin 3 , antithrombin , serpin C1 , serpin peptidase inhibitor, clade C, member 1 , ATIII , antithrombin III , serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1

GENE ID SPECIES
462 Homo sapiens
6031327 Culex quinquefasciatus
6045984 Culex quinquefasciatus
100173818 Pongo abelii
100379601 Cavia porcellus
11905 Mus musculus
424440 Gallus gallus
480066 Canis lupus familiaris
540261 Bos taurus
100125972 Sus scrofa
304917 Rattus norvegicus
443407 Ovis aries
100061173 Equus caballus
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