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Human MICA Protein expressed in Human Cells - ABIN2005167
Groh, Steinle, Bauer, Spies: Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells. dans Science (New York, N.Y.) 1998
Show all 2 Pubmed References
results suggest that head and neck squamous cell carcinoma patients who exhibit persistently elevated soluble MICA and TGF-beta1 levels after chemoradiotherapy are at higher risk of tumor progression or death
Results provide further evidence that genetic variants of MICA influence soluble MICA levels, and that Val mismatch at position 129 increases cytomegalovirus infection and kidney acute rejection risk during the first year post-pancreas-kidney transplantation .
Role of MICA in different cancer types (review).
The MICA A5.1 polymorphism was associated with a better CT morphologic response to chemotherapy and a reduced risk of relapse after Colorectal Liver Metastases resection.
According to our analysis, three proteins, namely aristaless-like homeobox1 isoform X1 (ALX1), major histocompatibility complex polypeptide-related sequence A (MICA), and uncharacterized protein C14orf105 isoform X12 were found to be potential markers for Opisthorchis viverrini (OV)- infection, as they were predominantly found in all OV-infected groups
MICA-129 val/val genotype, associated with higher levels of circulating sMICA, may influence disease susceptibility and associate with increased severity of rheumatoid arthritis in south Indian Tamils.
rs12524487 in HLA-B/MICA was a genetic risk factor for Takayasu arteritis in a Chinese Han population and rs9366782 in this region was associated with ischemic brain disease in TA but not TA susceptibility.
Here we discovered that an HCMV protein named UL148A whose role was hitherto unknown is required for evasion of NK cells. We demonstrate that UL148A-deficient HCMV strains are impaired in their ability to downregulate MICA expression.
allele MICA*002:01/A9 and haplotype MICA*002:01-MICB*005:02 were negatively associated with respiratory syncytial virus respiratory tract infections.
Levels of serum MICA were highly correlated to liver disease severity in chronic hepatitis C patients who carried the MICA rs738409 A allele.
Strategies to block MICA-NKG2D interactions resulted in reductions in IFNgamma production. Depletion of monocytes in vivo resulted in decreased IFNgamma production by murine NK cells upon exposure to Ab-coated tumor cells
A significant association was found between the Val allele and Val/Val genotype and the risk of breast cancer in Tunisian women.
the present study revealed that DNA damagedependent MICA/B expression in insensitive cancer cells can be restored by chromatin relaxation via the HDAC/Suv39/G9a pathway. Collectively, manipulation of chromatin status by therapeutic cancer drugs may potentiate the antitumor effect by enhancing immune activation following radiotherapy and DNA damage-associated chemotherapy.
Findings show that the efficient expression of cell-surface major histocompatibility class I-related chain molecule A (MICA) in the osteosarcoma cells requires asparagine (Asn)-N-linked glycosylation of MICA.
Study identified the novel role of transcription factors GATA-2 and GATA-3 in suppressing MICA/B expression in HBV-infected human hepatoma cells.
new MICA allelic variant, MICA*007:07, was identified in an individual of Mongol ethnicity in the Inner Mongolia Autonomous Region, northern China
inhibition of BET proteins can enhance the expression of MICA, a ligand of the NKG2D receptor, in human MM cell lines and primary malignant plasma cells, rendering myeloma cells more efficient to activate NK cell degranulation
results indicate that the polymorphism of rs2256318 in MICA may contribute to the etiology of Preterm birth through interfering with placental development. These findings need to be further validated in larger and multi-ethnic populations.
The results of this study suggested that the MICB*009N allele might be a risk factor for SLE, whereas the MICB*014, MICA*010 and MICB*002 alleles were associated with reduced incidence of SLE in the study population.
New truncated MICA isoforms exhibit a range of functions that may drive unexpected immune mechanisms and provide new tools for immunotherapy
MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants.
HLA class I antigen
, MHC class I chain-related protein A
, stress inducible class I homolog
, F10 alpha chain-like
, class I histocompatibility antigen