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Human MICA Protein expressed in HEK-293 Cells - ABIN2181502
Groh, Steinle, Bauer, Spies: Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells. dans Science (New York, N.Y.) 1998
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Human MICA Protein expressed in Human Cells - ABIN2005167
Xiang, Liu, Zheng, Liu, Lv, Gao, Hu, Lam, Chan, Yang, Chen, Tsao, Bonneville, Lau, Tu: Targeted activation of human V?9V?2-T cells controls epstein-barr virus-induced B cell lymphoproliferative disease. dans Cancer cell 2014
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The rs2596542 variant in the MICA promoter region may affect MICA and soluble MICA (sMICA) protein expression, thereby influencing physiological vulnerability to hepatocellular carcinoma (HCC) cells and the development of HCC.
the association of genetic factors with differential levels of soluble molecules were not evidenced, we displayed a synergistic effect of sMICA and sHLA-G in response to inflammation. This increase was observed in CKD patients, that when undergo transplantation, had this previous amount of immunoregulatory molecules as a positive factor for the allograft acceptance.
The inverse correlation between XBP1 and E2F1 or MICA expression was corroborated in RNA-Seq analysis.
this study shows no difference between prevalence of the MICA-129 Met/Val alleles between the preterm birth patients and the pregnant women controls
ow cellular MICA expressions were at a greater risk of hepatocellular carcinoma recurrence after curative treatment.
In this study no evidence was found of an association between the MICA*007 allele and ankylosing spondylitis susceptibility in a large cohort of European ancestry
New haplotypes have been found in 3' untranslated regions of MICA and MICB genes in international histocompatibility workshop lymphoblastoid cell lines.
The results suggest that increased serum MICA is closely related to the development and progression of non-small-cell lung carcinoma.
our data represent an advance in biomedical science because it shows raised sMICA in gastric cancer that predicts outcome, and as such may be thefirst useful laboratory index in this common malignancy.
These results indicate that the sMICA level may be associated with the prognosis of patients with prostate cancer. This work represents an advance in biomedical science because it shows that sMICA and EOD(Extend of Disease) are both prognostic factors that can be used to identify patients with a poor prognosis who may benefit from more aggressive management
This study showed that polymorphisms in MICA, but not in DEPDC5, HCP5 or PNPLA3, are associated with with chronic hepatitis C-related hepatocellular carcinoma development in Japanese patients with chronic hepatitis C virus infection.
our findings indicate that the MICA-129Val/Val variant is associated with significantly higher levels of sMICA and the progression of MM, strongly suggesting that the usage of soluble MICA as prognostic marker has to be definitely combined with the patient MICA genotype.
Han Chinese people from Hainan Island carrying MICA*009 or MICA*A6 allele have a higher risk to rheumatoid arthritis while MICB*002 and MICB*014 provide a protective role against RA.
Correlation between variants in extracellular domain of MICA and acute lymphocytic (lymphoblastic) leukemia (ALL), acute myeloid leukemia (AML), and myelodysplastic syndrome (MDS) in Korean population
we describe a transcript variant of human MICA that has not yet been studied, which contains a 3' untranslated region of 119 nt instead of 174.
Results show that activation of the p38/MAPK pathway may increase the expression of MICA and induce the expression of MMP-9. MMP-9 is involved in the shedding of sMICA from MICA to promote tumor immune escape. Furthermore, p38/MAPK could potentially represent a novel target for inhibiting tumor cell immune escape.
The C allele in MICA rs2596542 is a protective factor for hepatocarcinogenesis, whereas the T allele is a risk factor.
MICA may be a new biomarker for antenatal infection. MICA levels in uninfected premature newborns are as high as those in septic adult patients.
results suggest that head and neck squamous cell carcinoma patients who exhibit persistently elevated soluble MICA and TGF-beta1 levels after chemoradiotherapy are at higher risk of tumor progression or death
Results provide further evidence that genetic variants of MICA influence soluble MICA levels, and that Val mismatch at position 129 increases cytomegalovirus infection and kidney acute rejection risk during the first year post-pancreas-kidney transplantation .
MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants.
HLA class I antigen
, MHC class I chain-related protein A
, stress inducible class I homolog
, F10 alpha chain-like
, class I histocompatibility antigen