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Human MICA Protein expressed in Human Cells - ABIN2005167
Groh, Steinle, Bauer, Spies: Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells. dans Science (New York, N.Y.) 1998
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Human MICA Protein expressed in HEK-293 Cells - ABIN2181502
Bauer, Groh, Wu, Steinle, Phillips, Lanier, Spies: Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. dans Science (New York, N.Y.) 1999
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our data represent an advance in biomedical science because it shows raised sMICA in gastric cancer that predicts outcome, and as such may be thefirst useful laboratory index in this common malignancy.
These results indicate that the sMICA level may be associated with the prognosis of patients with prostate cancer. This work represents an advance in biomedical science because it shows that sMICA and EOD(Extend of Disease) are both prognostic factors that can be used to identify patients with a poor prognosis who may benefit from more aggressive management
This study showed that polymorphisms in MICA, but not in DEPDC5, HCP5 or PNPLA3, are associated with with chronic hepatitis C-related hepatocellular carcinoma development in Japanese patients with chronic hepatitis C virus infection.
our findings indicate that the MICA-129Val/Val variant is associated with significantly higher levels of sMICA and the progression of MM, strongly suggesting that the usage of soluble MICA as prognostic marker has to be definitely combined with the patient MICA genotype.
Han Chinese people from Hainan Island carrying MICA*009 or MICA*A6 allele have a higher risk to rheumatoid arthritis while MICB*002 and MICB*014 provide a protective role against RA.
Correlation between variants in extracellular domain of MICA and acute lymphocytic (lymphoblastic) leukemia (ALL), acute myeloid leukemia (AML), and myelodysplastic syndrome (MDS) in Korean population
we describe a transcript variant of human MICA that has not yet been studied, which contains a 3' untranslated region of 119 nt instead of 174.
Results show that activation of the p38/MAPK pathway may increase the expression of MICA and induce the expression of MMP-9. MMP-9 is involved in the shedding of sMICA from MICA to promote tumor immune escape. Furthermore, p38/MAPK could potentially represent a novel target for inhibiting tumor cell immune escape.
The C allele in MICA rs2596542 is a protective factor for hepatocarcinogenesis, whereas the T allele is a risk factor.
MICA may be a new biomarker for antenatal infection. MICA levels in uninfected premature newborns are as high as those in septic adult patients.
results suggest that head and neck squamous cell carcinoma patients who exhibit persistently elevated soluble MICA and TGF-beta1 levels after chemoradiotherapy are at higher risk of tumor progression or death
Results provide further evidence that genetic variants of MICA influence soluble MICA levels, and that Val mismatch at position 129 increases cytomegalovirus infection and kidney acute rejection risk during the first year post-pancreas-kidney transplantation .
Role of MICA in different cancer types (review).
The MICA A5.1 polymorphism was associated with a better CT morphologic response to chemotherapy and a reduced risk of relapse after Colorectal Liver Metastases resection.
According to our analysis, three proteins, namely aristaless-like homeobox1 isoform X1 (ALX1), major histocompatibility complex polypeptide-related sequence A (MICA), and uncharacterized protein C14orf105 isoform X12 were found to be potential markers for Opisthorchis viverrini (OV)- infection, as they were predominantly found in all OV-infected groups
MICA-129 val/val genotype, associated with higher levels of circulating sMICA, may influence disease susceptibility and associate with increased severity of rheumatoid arthritis in south Indian Tamils.
rs12524487 in HLA-B/MICA was a genetic risk factor for Takayasu arteritis in a Chinese Han population and rs9366782 in this region was associated with ischemic brain disease in TA but not TA susceptibility.
Here we discovered that an HCMV protein named UL148A whose role was hitherto unknown is required for evasion of NK cells. We demonstrate that UL148A-deficient HCMV strains are impaired in their ability to downregulate MICA expression.
allele MICA*002:01/A9 and haplotype MICA*002:01-MICB*005:02 were negatively associated with respiratory syncytial virus respiratory tract infections.
Levels of serum MICA were highly correlated to liver disease severity in chronic hepatitis C patients who carried the MICA rs738409 A allele.
MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants.
HLA class I antigen
, MHC class I chain-related protein A
, stress inducible class I homolog
, F10 alpha chain-like
, class I histocompatibility antigen