IKK alpha anticorps

N° du produit ABIN110582

L’anticorps anti-IKK alpha Polyclonal Lapin est utilisé pour la détection de IKK alpha dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour IKK alpha anticorps (ABIN110582)

Antigène: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IKK alpha est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-IKK alpha anticorps

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Stock: 4 °C

Détails sur IKK alpha

Antigène: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Autre désignation: IKKa (IkB Kinase)

Sujet: IKKa (I. B kinase-a , or IKK-1) is part of a large protein complex responsible for the inducible phos-phorylation of I. B proteins. The same protein was originally identified as CHUK (conserved helix-loop-helix ubiquitous kinase), a serine/threonine kinase of unknown function. The human IKKa is a 85 kDa peptide that has been shown to activate NF-. B by phos-phorylation of I. B proteins. IKKa interacts with its upstream kinase, NIK, and its downstream substrate, the I. B proteins. Mutations of IKKa in its kinase domain lead to a dominant-negative phenotype that suppresses TNFa and IL-1ß induced NF-. B activaiton.

Pathways: Signalisation PI3K-Akt, Signalisation NF-kappaB, Signalisation RTK, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins