FOXO3 anticorps (Forkhead Box O3) (pSer253)

Details for Product anti-FOXO3 Antibody No. ABIN1355835
Antigène
  • AF6q21
  • FKHRL1
  • FKHRL1P2
  • FOXO2
  • FOXO3A
  • zgc:92176
  • wu:fb50g02
  • wu:fi33f07
  • Fkhrl1
  • Foxo3a
  • FoxO3A
  • 1110048B16Rik
  • 2010203A17Rik
  • C76856
  • Fkhr2
  • FOXO-3
  • FOXO3
  • foxo3a
  • xfoxo3
  • foxO3
  • foxO
  • forkhead box O3
  • forkhead box O3A
  • forkhead box O3 L homeolog
  • FOXO3
  • foxo3a
  • Foxo3
  • foxo3.L
  • foxo3
  • foxO3
Épitope
pSer253
70
46
30
24
17
10
10
9
9
9
9
8
8
8
8
7
7
7
5
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
399
236
204
20
15
11
9
9
8
7
6
5
4
4
3
1
1
1
Hôte
Lapin
327
54
22
1
Clonalité
Polyclonal
Conjugué
Cet anticorp FOXO3 est non-conjugé
21
15
15
15
15
15
15
8
7
5
5
5
2
2
2
2
2
1
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
268
166
153
80
76
27
19
15
9
9
5
2
1
1
1
Options
Immunogène Peptide sequence around phosphorylation site of pSer253 (A-V-S (p) -M-D) derived from Human FKHRL1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
Specificité The antibody detects endogenous level of FKHRL1 only when phosphorylated at serine 253.
Plasmids, Primers & others Plasmids, Primers & others FOXO3 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation FKHRL1 (FOXO3 Antibody Extrait)
Sujet  Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
Poids moléculaire 97 kDa
NCBI Accession NP_001446, NM_001455
UniProt O43524
Pathways Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis
Indications d'application Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Immunofluorescence: 1:100-1:200
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C/-20 °C
Stockage commentaire Store at -20 °C
Produit citée dans: Pierce, Podlutskaya, Halloran, Hussong, Lin, Burbank, Hart, Galvan: "Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease." dans: Journal of neurochemistry, Vol. 124, Issue 6, pp. 880-93, 2013 (PubMed).

Zhan, Wang, Li, Xu, Sun, Xu: "Activation of Akt/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hypoxic pre-conditioning in adult rats." dans: Journal of neurochemistry, Vol. 114, Issue 3, pp. 897-908, 2010 (PubMed).

Background publications Kress, Cannell, Brenkman, Samans, Gaestel, Roepman, Burgering, Bushell, Rosenwald, Eilers: "The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis." dans: Molecular cell, Vol. 41, Issue 4, pp. 445-57, 2011 (PubMed).

Morishita, Katayama, Sekimizu, Tsuruo, Fujita: "Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels." dans: Cancer research, Vol. 68, Issue 13, pp. 5076-85, 2008 (PubMed).

Lehtinen, Yuan, Boag, Yang, Villén, Becker, DiBacco, de la Iglesia, Gygi, Blackwell, Bonni: "A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span." dans: Cell, Vol. 125, Issue 5, pp. 987-1001, 2006 (PubMed).