P2RX7 anticorps (C-Term)

N° du produit ABIN1742370

Détail du produit anti-P2RX7 anticorps

Antigène: P2RX7 (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7))

Épitope: AA 363-595, C-Term

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp P2RX7 est non-conjugé

Application: Western Blotting (WB)

Specificité: Specific for P2X7.

Purification: Affinity purified with the immunogen. Rabbit serum albumin was added for stabilization.

Immunogène: Recombinant cytoplasmic C-terminal tail of mouse P2X7 (aa 363-595).

Information d'application

Indications d'application: WB: 1 : 1000 (AP staining)
IP: not tested yet
ICC: not tested yet
IHC: not tested yet

Commentaires:

Detects mouse protein with higher sensitivity. This antibody detects an additional band at 30 kDa of unknown identity.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: For reconstitution add 50 µL H2O to get a 1mg/ml solution of antibody in PBS. Then aliquot and store at -20 °C until use.

Buffer: PBS

Conseil sur la manipulation: Affinity purified antibodies are less robust than antisera, since protease inhibitors are also removed during purification. Hence, storage at 4 °C for prolonged periods (i.e. several weeks), is not recommended.

Stock: -20 °C

Stockage commentaire: Unlabeled lyophilized antibodies are stable in this form without loss of quality at ambient temperatures for several weeks or even months. They can be stored at 4°C for several years. Lyophilized antibodies must not be stored in the freezer, they may be destroyed!

Références pour anticorps anti-P2RX7 (ABIN1742370)

Young, Sinadinos, Lefebvre, Chan, Arkle, Vaudry, Gorecki: "A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90." dans: Autophagy, Vol. 11, Issue 1, pp. 113-30, (2015) (PubMed).

Young, Brutkowski, Lien, Arkle, Lochmüller, Zabłocki, Górecki: "P2X7 purinoceptor alterations in dystrophic mdx mouse muscles: relationship to pathology and potential target for treatment." dans: Journal of cellular and molecular medicine, Vol. 16, Issue 5, pp. 1026-37, (2012) (PubMed).

Masin, Young, Lim, Barnes, Xu, Marschall, Brutkowski, Mooney, Gorecki, Murrell-Lagnado: "Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: re-evaluation of P2X7 knockouts." dans: British journal of pharmacology, Vol. 165, Issue 4, pp. 978-93, (2012) (PubMed).

Détails sur P2RX7

Antigène: P2RX7 (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7))

Autre désignation: P2X7 (P2RX7 Produits)

Synonymes: anticorps p2xr7, anticorps P2RX7, anticorps P2X7, anticorps AI467586, anticorps P2X(7), anticorps P2X7R, anticorps p2x7, anticorps purinergic receptor P2X 7, anticorps purinergic receptor P2X, ligand-gated ion channel, 7, anticorps P2X purinoceptor 7, anticorps P2RX7, anticorps p2rx7, anticorps LOC100458463, anticorps P2rx7

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Vesicle Exocytosis