EPOR anticorps (Extracellular Domain)

N° du produit ABIN1819428

Détail du produit anti-EPOR anticorps

Antigène: EPOR (Erythropoietin Receptor (EPOR))

Épitope: Extracellular Domain

Reactivité: Humain, Souris

Hôte: Mouton

Clonalité: Polyclonal

Conjugué: Cet anticorp EPOR est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Specificité: Recognizes Erythropoietin Receptor (EPOR), a type I transmembrane protein and member of the type I cytokine receptor family, expressed by erythroid cells and erythroid progenitor cells, which acts as a receptor for erythropoietin (EPO) to mediate erythroblast proliferation and differentiation, and maintain progenitor survival. Binding of EPO to EPOR, results in the dimerization of the EPOR and the triggering of the JAK2/STAT5 signaling cascade, and in some cell types activation of STAT1 and STAT3. Several isoforms of EPOR exist: EPOR-F, EPOR-S and EPOR-T, and a functional EPOR is found on endothelial cells and cardiomyocytes within the cardiovascular system, suggesting a role in cardiac function. AHP1825 has been shown to block Iodine125 labeled erythropoietin ligand binding using erythroleukemia cell line TF-1 with 3000 EPOR/cell in neutralization studies, see for details. AHP1825 is reported as suitable for use in immunocytochemistry. AHP1825 has been reported for use in functional studies. Removal of Sodium Azide is recommended prior to use in functional assays. The recommended concentration for functional assays is 500 μg/mL.

Purification: Affinity purified

Immunogène: Partial cDNA of the extracellular domain of human EpoR expressed as a GST fusion protein in E. coli.

Type of Immunogen: Fusion protein

Isotype: IgG

Information d'application

Indications d'application: Approved: ELISA, IP (10 μg/mL), WB (10 μg/mL)

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 4°C. Do not freeze.

Détails sur EPOR

Antigène: EPOR (Erythropoietin Receptor (EPOR))

Autre désignation: EPOR / EPO Receptor (EPOR Produits)

Synonymes: anticorps EPOR, anticorps epor, anticorps EPO-R, anticorps erythropoietin receptor, anticorps erythropoietin receptor L homeolog, anticorps EPOR, anticorps epor, anticorps Epor, anticorps epor.L

Sujet: Name/Gene ID: EPOR
Family: Cytokine Receptor

Synonyms: EPOR, EPO Receptor, EPO-R, Erythropoietin receptor

ID gène: 2057

Pathways: Signalistation JAK/STAT