IKK alpha anticorps (N-Term)

N° du produit ABIN1881203

Il existe 5+ publications pour ce produit. L’anticorps anti-IKK alpha Polyclonal Lapin est utilisé pour la détection de IKK alpha dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour IKK alpha anticorps (N-Term) (ABIN1881203)

Antigène: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IKK alpha est non-conjugé

Application: Western Blotting (WB)

Clone: RB41290

Détail du produit anti-IKK alpha anticorps

Épitope: AA 84-112, N-Term

Homologie: B, C, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This CHUK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-112 amino acids from the N-terminal region of human CHUK.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-IKK alpha (ABIN1881203)

Lahtela, Nousiainen, Stefanovic, Tallila, Viskari, Karikoski, Gentile, Saloranta, Varilo, Salonen, Kestilä: "Mutant CHUK and severe fetal encasement malformation." dans: The New England journal of medicine, Vol. 363, Issue 17, pp. 1631-7, (2010) (PubMed).

Gouin, Adib-Conquy, Balestrino, Nahori, Villiers, Colland, Dramsi, Dussurget, Cossart: "The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 40, pp. 17333-8, (2010) (PubMed).

Cummins, Oliver, Lenihan, Fitzpatrick, Bruning, Scholz, Slattery, Leonard, McLoughlin, Taylor: "NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 4439-45, (2010) (PubMed).

Li, Morgan, Choksi, Zhang, Kim, Liu: "MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation." dans: Nature immunology, Vol. 11, Issue 9, pp. 799-805, (2010) (PubMed).

Rotman, Koh, Zmuda, Kleiner, Liang: "The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease." dans: Hepatology (Baltimore, Md.), Vol. 52, Issue 3, pp. 894-903, (2010) (PubMed).

Détails sur IKK alpha

Antigène: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Autre désignation: CHUK

Sujet: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.

Poids moléculaire: 84640

NCBI Accession: NP_001269

UniProt: O15111

Pathways: Signalisation PI3K-Akt, Signalisation NF-kappaB, Signalisation RTK, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins