IKK alpha anticorps (AA 699-715)

N° du produit ABIN1886895

Cet anticorps anti-IKK alpha est un anticorps Lapin Polyclonal détectant IKK alpha dans WB, ELISA et ICC. Adapté pour Humain.

Aperçu rapide pour IKK alpha anticorps (AA 699-715) (ABIN1886895)

Antigène: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IKK alpha est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-IKK alpha anticorps

Épitope: AA 699-715

Réactivité croisée (Details): This polyclonal antibody has no cross response to IKKb or IKKy.

Purification: Affinity chromatography purified via peptide column

Immunogène: Peptide corresponding to amino acids 699 to 715 of human IKK alpha, which differs from corresponding murine sequence by one amino acid.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur IKK alpha

Antigène: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Autre désignation: IKK alpha

Sujet: Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses.NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and bacteria product LPS.NF-kappaB is associated with IkappaB proteins in the cell cytoplasm, which inhibit NF-kappaB activity.The long-sought IkappaB kinase (IKK), which phosphorylates IkappaB, and mediates IkappaB degradation and NF-kappaB activation, was recently identified by several laboratories.IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKalpha and IKKbeta).IKKalpha and IKKbeta interact with each other and both are essential for the NF-kappaB activation.IKKalpha specifically phosphorylates IkappaB-alpha.IKKalpha is expressed in a variety of human tissues.
Synonyms: Inhibitor of nuclear factor kappa-B kinase alpha subunit, IkappaB kinase alpha, NFkappaB inhibitor kinase alpha, IKKa

Poids moléculaire: 85 kDa

Pathways: Signalisation PI3K-Akt, Signalisation NF-kappaB, Signalisation RTK, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins